Simultaneous quantitative determination of Insulin Aspart and Insulin Degludec in human plasma using simple shoot liquid chromatography method

2021 ◽  
Author(s):  
Eman A. Abdelwaly ◽  
Abeer A. Mohamed ◽  
Amira M. El‐Kosasy ◽  
Miriam F. Ayad
Keyword(s):  
Liquid Chromatography ◽  
Quantitative Determination ◽  
Human Plasma ◽  
Insulin Aspart ◽  
Insulin Degludec ◽  
Chromatography Method ◽  
Liquid Chromatography Method

High performance liquid chromatography method for the determination of doxycycline in human plasma

1998 ◽  
Vol 47 (9-10) ◽  
pp. 547-549 ◽  
Author(s):  
D. Farin ◽  
G. Piva ◽  
I. Gozlan ◽  
R. Kitzés
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Human Plasma ◽  
High Performance ◽  
Chromatography Method ◽  
Liquid Chromatography Method

First liquid chromatography method for the simultaneous determination of levofloxacin, pazufloxacin, gatifloxacin, moxifloxacin and trovafloxacin in human plasma

2013 ◽  
Vol 930 ◽  
pp. 104-111 ◽  
Author(s):  
Joana Sousa ◽  
Gilberto Alves ◽  
Gonçalo Campos ◽  
Ana Fortuna ◽  
Amílcar Falcão
Keyword(s):  
Liquid Chromatography ◽  
Simultaneous Determination ◽  
Human Plasma ◽  
Chromatography Method ◽  
Liquid Chromatography Method

A simple and sensitive liquid chromatography method for the determination of low dihydrocodeine concentrations in human plasma: its application in Chinese healthy volunteers

2011 ◽  
Vol 61 (07) ◽  
pp. 411-416 ◽  
Author(s):  
Wei Tang ◽  
Xinxia Liu ◽  
Xiangjun Qiu ◽  
Shiying Yuan ◽  
Jing Wang ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Healthy Volunteers ◽  
Human Plasma ◽  
Chromatography Method ◽  
Liquid Chromatography Method

scholarly journals A SIMPLE REVERSE PHASE-HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD DEVELOPMENT AND VALIDATION OF VALSARTAN IN BULK AND IT’S TABLET DOSAGE FORM

2017 ◽  
Vol 10 (12) ◽  
pp. 333
Author(s):  
Ramreddy Godela ◽  
Sherisha Bhavani
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Quantitative Determination ◽  
High Performance ◽  
Dosage Form ◽  
Reverse Phase ◽  
Chromatography Method ◽  
Liquid Chromatography Method ◽  
Tablet Dosage

Objective: The most important objective of the present research work is to develop simple, specific, rapid, accurate, and sensitive reverse-phase high-performance liquid chromatography method and validated for the qualitative and quantitative determination of valsartan in its active pharmaceutical ingredient and tablet dosage form according to ICH guidelines.Proposed Method: An isocratic separation was done using Phenomenex C18 column possess 75×4.6 mm, 2.6 μ,100 A0 dimensions with mobile phase composition of water:acetonitrile (30:70% v/v) by maintaining 1 ml/minute flow rate and response detected at a wavelength of 247 nm.Results: The retention time of valsartan was found to be 2.71 minutes, limit of detection and limit of quantification were observed at 1.24 μg/ml and 3.6 μg/ml concentration, respectively, and a calibration curve was linear in the concentration range of 5-50 μg/ml with coefficient of correlation 0.99. The percentage recovery (accuracy) was in the range of 98.9-102%, and the % relative standard deviation was observed to be <2%.Conclusion: The proposed method was validated for accuracy, precision, sensitivity, linearity, and robustness and successfully employed for the quantitative determination of valsartan in tablet dosage form in quality control department of pharmaceutical industry.

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