scholarly journals Neuroimaging consequences of cerebral small vessel disease in patients with obstructive sleep apnea–hypopnea syndrome

2019 ◽  
Vol 9 (8) ◽  
Author(s):  
Shujian Huang ◽  
Dan Wang ◽  
Huiqun Zhou ◽  
Zhengnong Chen ◽  
Hui Wang ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease ◽  
Obstructive Sleep ◽  
Hypopnea Syndrome

scholarly journals Effect of obstructive sleep apnea on cerebrovascular compliance and cerebral small vessel disease

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259469
Author(s):  
Woo-Jin Lee ◽  
Keun-Hwa Jung ◽  
Hyun-Woo Nam ◽  
Yong-Seok Lee
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Confidence Interval ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Apnea Hypopnea Index ◽  
Volume Number ◽  
Vessel Disease ◽  
Obstructive Sleep

Reduced cerebrovascular compliance is the major mechanism of cerebral small vessel disease (SVD). Obstructive sleep apnea (OSA) also promotes SVD development, but the underlying mechanism was not elucidated. We investigated the association among OSA, cerebrovascular compliance, and SVD parameters. This study retrospectively included individuals ≥ 50 years of age, underwent overnight polysomnographic (PSG) for the evaluation of OSA, and performed MRI and transcranial Doppler (TCD) within 12 months of interval without a neurological event between the evaluations. TCD parameters for the cerebrovascular compliance included middle cerebral artery pulsatility index (MCA PI) and mean MCA resistance index ratio (MRIR). SVD parameters included white matter hyperintensity (WMH) volume, number of lacunes, enlarged perivascular space (ePVS) score, and the presence of microbleeds or lacunes. Ninety-seven individuals (60.8% male, mean age 70.0±10.5 years) were included. MRIR was associated with higher respiratory distress index (B = 0.003; 95% confidence interval [CI] 0.001–0.005; P = 0.021), while MCA PI was not associated with any of the PSG markers for OSA severity. Apnea-hypopnea index was associated with the log-transformed total WMH volume (B = 0.008; 95% confidence interval [CI] 0.001–0.016; P = 0.020), subcortical WMH volume (B = 0.015; 95% CI 0.007–0.022; P<0.001), total ePVS score (B = 0.024; 95% CI 0.003–0.045; P = 0.026), and centrum semiovale ePVS score (B = 0.026; 95% CI 0.004–0.048; P = 0.019), and oxygen-desaturation index with periventricular WMH volume, independently from age, MCA PI, and MRIR. This study concluded that OSA is associated with reduced cerebrovascular compliance and also with SVD independently from cerebrovascular compliance. Underlying pathomechanistic link might be region specific.

Moderate-to-severe obstructive sleep apnea is associated with cerebral small vessel disease

2017 ◽  
Vol 30 ◽  
pp. 36-42 ◽  
Author(s):  
Tae-Jin Song ◽  
Jung-Hyun Park ◽  
Kang Hyun Choi ◽  
Yoonkyung Chang ◽  
Jangsup Moon ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Severe Obstructive Sleep Apnea ◽  
Vessel Disease ◽  
Obstructive Sleep

scholarly journals Association of obstructive sleep apnea and cerebral small vessel disease: a systematic review and meta-analysis

SLEEP ◽  
2019 ◽  
Vol 43 (4) ◽  
Author(s):  
Yuhong Huang ◽  
Chunsong Yang ◽  
Ruozhen Yuan ◽  
Ming Liu ◽  
Zilong Hao
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Small Vessel Disease ◽  
Meta Analysis ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Current Evidence ◽  
Cochrane Library ◽  
Vessel Disease ◽  
Obstructive Sleep

Abstract Study Objectives The objective of the present study was to investigate the association between obstructive sleep apnea (OSA) and the presence of various neuroimaging marker of cerebral small vessel disease (CSVD). Methods We systematically searched PubMed, Embase, Web of Science, Scopus, and Cochrane library (from inception to May 2019) for studies evaluating the association between OSA and CSVD, which included white matter hyperintensities (WMH), silent brain infarction (SBI), cerebral microbleeds (CMBs), and perivascular spaces (PVS). Pooled odds ratios (ORs) with 95% confidence interval (CIs) were estimated using random-effects meta-analysis. Results After screening 7290 publications, 20 studies were finally included involving 6036 subjects. The sample size ranged from 27 to 1763 (median 158, interquartile range: 67–393). The meta-analysis showed that moderate to severe OSA was positively associated with WMH (13 studies, n = 4412, OR = 2.23, 95% CI = 1.53 to 3.25, I2 = 80.3%) and SBI (12 studies, n = 3353, OR 1.54, 95% CI = 1.06 to 2.23, I2 = 52%). There was no association with CMBs (three studies, n = 342, OR = 2.17, 95% CI = 0.61 to 7.73, I2 = 60.2%) or PVS (two studies, n = 267, OR = 1.56, 95% CI = 0.28 to 8.57, I2 = 69.5%). There was no relationship between mild OSA and CSVD. Conclusion Current evidence suggests that moderate to severe sleep apnea is positively related to WMH and SBI, but not CMBs or PVS, which suggests that OSA may contribute to the pathogenesis of CSVD. Further large cohort studies should be prioritized to confirm the findings.

Impact of obstructive sleep apnea on silent cerebral small vessel disease: a systematic review and meta-analysis

2020 ◽  
Vol 68 ◽  
pp. 80-88 ◽  
Author(s):  
Anthipa Chokesuwattanaskul ◽  
Ploypin Lertjitbanjong ◽  
Charat Thongprayoon ◽  
Tarun Bathini ◽  
Konika Sharma ◽  
...  
Keyword(s):  
Systematic Review ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Small Vessel Disease ◽  
Meta Analysis ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease ◽  
Obstructive Sleep

scholarly journals Clinically Silent Small Vessel Disease of the Brain in Patients with Obstructive Sleep Apnea Hypopnea Syndrome

Diagnostics ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1673
Author(s):  
Dimitrios G. Raptis ◽  
Olga Sinani ◽  
Georgia G. Rapti ◽  
Aikaterini Papanikolaou ◽  
Katerina Dadouli ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
White Matter ◽  
Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease ◽  
Obstructive Sleep ◽  
Increased Risk ◽  
Hypopnea Syndrome ◽  
The Brain

Obstructive sleep apnea hypopnea syndrome (OSAHS) is associated with increased risk of cerebrovascular disease. The aim of the present study was to investigate the association between the presence of the small vessel disease (SVD) of the brain in patients with OSAHS. The study included 24 patients with moderate to severe OSAHS and 34 healthy volunteers. All the subjects underwent magnetic resonance imaging (MRI) of the brain, in order to sought periventricular white matter (PVWM), deep white matter (DWM) and brainstem SVD. Among patients with OSAHS, 79.1% had SVD (grade 1–3, Fazekas score) in DWM and 91.7% in PVWM while 22.4% had brainstem—white matter hyperintensities (B-WMH). Patients with OSAHS had a much higher degree of SVD in the DWM and PVWM compared to the control group (p < 0.001). The multivariate analysis showed an independent significant association of OSAHS with SVD (DWM and PVWM) (p = 0.033, OR 95% CI: 8.66 (1.19–63.08) and: p = 0.002, OR 95% CI: 104.98 (5.15–2141)). The same analysis showed a moderate association of OSAHS with B-WMH (p = 0.050, OR 15.07 (0.97–234.65)). Our study demonstrated an independent significant association of OSAHS with SVD and a moderate association of OSAHS with B-WMH.

Association of obstructive sleep apnea with cognitive impairment and small vessel disease

2019 ◽  
Author(s):  
Liliana Otero ◽  
Alain Riveros-Rivera ◽  
Pablo Reyes ◽  
Luis Uriza ◽  
Diana Matallana ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Cognitive Impairment ◽  
Sleep Apnea ◽  
Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease ◽  
Obstructive Sleep
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