scholarly journals Evaluation of Single‐use Tangential Flow Filtration Technology for Purification of Activated Polysaccharides Used in Conjugate Vaccine Manufacturing

2021 ◽  
Author(s):  
Seyed Pouria Motevalian ◽  
Jonathan Steen ◽  
Janine De Leon ◽  
Verl Sriskanda ◽  
Ivette Carino ◽  
...  
Keyword(s):  
Conjugate Vaccine ◽  
Tangential Flow Filtration ◽  
Tangential Flow ◽  
Single Use ◽  
Flow Filtration ◽  
Filtration Technology

scholarly journals Evaluation of Single-use Tangential Flow Filtration Technology for Purification of Activated Polysaccharides Used in Conjugate Vaccine Manufacturing

2021 ◽  
Author(s):  
Seyed Pouria Motevalian ◽  
Jonathan Steen ◽  
Janine De Leon ◽  
Verl Sriskanda ◽  
Ivette Carino ◽  
...  
Keyword(s):  
Process Development ◽  
Average Molecular Weight ◽  
Weighted Average ◽  
Process Performance ◽  
Product Attributes ◽  
Tangential Flow Filtration ◽  
Tangential Flow ◽  
Single Use ◽  
Flow Filtration ◽  
Manufacturing Time

Over the past decade, single-use tangential flow filtration (TFF) technologies have emerged to reduce system preparation time, promote fast and flexible product change over, and ultimately shorten process development and manufacturing time/cost. In this study, the performance of a recently developed Pellicon® single-use TFF capsule was compared against traditional Pellicon® cassette by assessing TFF process performance (such as flux, residuals clearance, and yield) and post-purification product attributes (such as concentration and mass-weighted average molecular weight). Good scaling was shown by comparing process performance and product attributes across different scales and formats. Additionally, similar TFF process performance and post-purification product attributes were observed for the single-use capsule compared to the reusable TFF cassettes. The capsule requires a smaller flush than the cassette, and it is easier to use since it does not require a compression holder or pre-sanitization. The results provide insight into the application of the single-use TFF capsule and scalability of TFF processes for the purification of conjugate vaccines.

Single-use, single-pass tangential flow filtration using low-cost hollow fiber modules

2020 ◽  
Vol 595 ◽  
pp. 117517 ◽  
Author(s):  
Christopher J. Yehl ◽  
Andrew L. Zydney
Keyword(s):  
Hollow Fiber ◽  
Low Cost ◽  
Tangential Flow Filtration ◽  
Single Pass ◽  
Tangential Flow ◽  
Single Use ◽  
Flow Filtration

Measurement of dissolved aluminium in waters: use of the tangential flow filtration technology

1998 ◽  
Vol 32 (4) ◽  
pp. 1019-1026 ◽  
Author(s):  
Jianping Lin ◽  
Bruce A.W Coller
Keyword(s):  
Tangential Flow Filtration ◽  
Tangential Flow ◽  
Flow Filtration ◽  
Filtration Technology

One-Pot Synthesis, Purification, and Formulation of Bionanoparticle−CpG Oligodeoxynucleotide Hepatitis B Surface Antigen Conjugate Vaccine via Tangential Flow Filtration

2007 ◽  
Vol 18 (2) ◽  
pp. 285-288 ◽  
Author(s):  
Krishnaswami Raja ◽  
Ross McDonald ◽  
Stephen Tuck ◽  
Roberto Rodriguez ◽  
Bob Milley ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Conjugate Vaccine ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
One Pot ◽  
Tangential Flow Filtration ◽  
Tangential Flow ◽  
One Pot Synthesis ◽  
Cpg Oligodeoxynucleotide ◽  
Flow Filtration

Tangential flow filtration technology applicable to large scale recovery of diphtheria toxin

2002 ◽  
Vol 94 (2) ◽  
pp. 93-98 ◽  
Author(s):  
Bheeman Sundaran ◽  
Chitrambalam Palaniappan ◽  
Yarlagadda Udaya Bhaskara Rao ◽  
Ratnam Boopathy ◽  
Lakshman Narasingha Rao Bhau
Keyword(s):  
Diphtheria Toxin ◽  
Large Scale ◽  
Tangential Flow Filtration ◽  
Tangential Flow ◽  
Flow Filtration ◽  
Filtration Technology

Concentration of live pico- and nanoplankton by means of tangential flow filtration

1989 ◽  
Vol 11 (6) ◽  
pp. 1213-1221 ◽  
Author(s):  
Klaus-Günther Barthel ◽  
Gerald Schneider ◽  
Rolf Gradinger ◽  
Jürgen Lenz
Keyword(s):  
Tangential Flow Filtration ◽  
Tangential Flow ◽  
Flow Filtration

High performance tangential flow filtration

1997 ◽  
Vol 56 (1) ◽  
pp. 71-82 ◽  
Author(s):  
Robert van Reis ◽  
Shishir Gadam ◽  
Leah N. Frautschy ◽  
Scott Orlando ◽  
Elizabeth M. Goodrich ◽  
...  
Keyword(s):  
High Performance ◽  
Tangential Flow Filtration ◽  
Tangential Flow ◽  
Flow Filtration

Author response for "Modulation of transmembrane pressure in manufacturing scale tangential flow filtration N‐1 perfusion seed culture"

2020 ◽  
Author(s):  
Daniel J Karst ◽  
Kevin Ramer ◽  
Erik H Hughes ◽  
Canping Jiang ◽  
Pieter J Jacobs ◽  
...  
Keyword(s):  
Author Response ◽  
Transmembrane Pressure ◽  
Tangential Flow Filtration ◽  
Tangential Flow ◽  
Seed Culture ◽  
Flow Filtration
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