scholarly journals Survival benefits of simple versus extended cholecystectomy and lymphadenectomy for patients with T1b gallbladder cancer: An analysis of the surveillance, epidemiology, and end results database (2004 to 2013)

2020 ◽  
Vol 9 (11) ◽  
pp. 3668-3679 ◽  
Author(s):  
Li Xu ◽  
Haidong Tan ◽  
Xiaolei Liu ◽  
Jia Huang ◽  
Liguo Liu ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Extended Cholecystectomy ◽  
End Results

scholarly journals Prognostic Significance of Tumor Location in T2 Gallbladder Cancer: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 10 (15) ◽  
pp. 3317
Author(s):  
Hyun Kang ◽  
Yoo Shin Choi ◽  
Suk-Won Suh ◽  
Geunjoo Choi ◽  
Jae Hyuk Do ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Large Scale ◽  
Treatment Guidelines ◽  
Prognostic Significance ◽  
Tumor Location ◽  
Cochrane Library ◽  
Poor Prognostic Factor ◽  
Simple Cholecystectomy ◽  
Survival Difference ◽  
Extended Cholecystectomy

(1) Background: The AJCC Cancer Staging Manual, Eighth Edition, subdivided T2 GBC into T2a and T2b. However, there still exist a lack of evidence on the prognostic significance of tumor location. The aim of the present study was to examine the existing evidence to determine the prognostic significance of tumor location of T2 gallbladder cancer (GBC) and to evaluate the optimal surgical extent according to tumor location. (2) Methods: We searched for relevant literature published in the electronic databases PubMed, MEDLINE, Web of Science, Cochrane Library, and Embase before September 2020 using search terms related to gallbladder, cancer, and stage. Data were weighted and pooled using random-effects modeling. (3) Results: Seven studies were deemed eligible for inclusion, representing a cohort of 1789 cases of resected T2 GBC. The overall survival for T2b tumor was significantly worse than that for T2a tumor (HR, 2.141; 95% confidence interval (CI), 1.140 to 4.023; I2 = 71.4%; Pchi2 = 0.007). The rate of lymph node metastasis was lower in the T2a group (26.6%) than in the T2b group (36.6%) (OR, 2.164; 95% CI, 1.309 to 3.575). There was no evidence of a survival difference between the patients who underwent extended cholecystectomy and simple cholecystectomy in T2a GBC (OR, 0.802; 95% CI, 0.618 to 1.042) and T2b GBC (OR, 0.820; 95% CI, 0.620 to 1.083). (4) Conclusions: Hepatic side tumor was a significant poor prognostic factor in T2 GBC. Extended cholecystectomy and simple cholecystectomy showed comparable survival outcomes in T2 GBC, and additional large-scale prospective studies are warranted to establish evidence-based treatment guidelines for T2 GBC.

Laparoscopic extended cholecystectomy for T3 gallbladder cancer

2017 ◽  
Vol 32 (6) ◽  
pp. 2984-2985 ◽  
Author(s):  
Sungho Kim ◽  
Yoo-Seok Yoon ◽  
Ho-Seong Han ◽  
Jai Young Cho ◽  
YoungRok Choi
Keyword(s):  
Gallbladder Cancer ◽  
Extended Cholecystectomy

scholarly journals Survival Benefits of Simple Versus Extended Cholecystectomy and Lymphadenectomy for Patients With T2 Gallbladder Cancer: A Propensity-Matched Population-Based Study (2010 to 2015)

2021 ◽  
Vol 11 ◽  
Author(s):  
Wei Zhang ◽  
Zhangkan Huang ◽  
Wen-er Wang ◽  
Xu Che
Keyword(s):  
Overall Survival ◽  
Propensity Score ◽  
Gallbladder Cancer ◽  
Propensity Score Matching ◽  
Survival Benefit ◽  
Confounding Factors ◽  
Simple Cholecystectomy ◽  
Regional Lymphadenectomy ◽  
Extended Cholecystectomy ◽  
Significant Survival

ObjectiveThis article aims to evaluate the survival benefits of simple cholecystectomy, extended cholecystectomy, as well as scope regional lymphadenectomy for T2 gallbladder cancer (GBC) patients.MethodsWe identified eligible patients from the Surveillance, Epidemiology, and End Results database. The confounding factors were controlled via propensity score matching. The log-rank test was utilized to compare overall survival. The multivariate Cox regression was then used to determine risk factors.ResultsOverall, data from 1,009 patients were obtained. The median overall survival (OS) of 915 patients that underwent simple cholecystectomy was 15 months; the median OS of 94 patients that underwent extended cholecystectomy was 17 months. There were no significant differences before and after propensity score matching (p = 0.542 and p = 0.258). The patients who received regional lymphadenectomy did show significant survival benefit, compared to those who did not receive regional lymphadenectomy. Furthermore, this benefit is observed in the N0 stage, but not observed in the N1 stage. In addition, the OS of patients who received lymphadenectomy for four or more regions was significantly better than those who received one to three regions lymphadenectomy. Age, the scope of regional lymphadenectomy, N stage, and tumor size were identified as prognostic factors.ConclusionsExtended cholecystectomy was not observed to significantly improve postoperative prognosis of patients with T2 GBC. However, there was a significant survival benefit shown for those with regional lymphadenectomy, particularly for patients with negative lymph nodes. Future studies on the control of potential confounding factors and longer follow-ups are still needed.

scholarly journals Minimally invasive surgery for gallbladder cancer at an expert center

2021 ◽  
Author(s):  
Jun-Suh Lee ◽  
Ho-Seong Han ◽  
Yoo-Seok Yoon ◽  
Jai-Young Cho ◽  
Hae-Won Lee ◽  
...  
Keyword(s):  
Minimally Invasive Surgery ◽  
Minimally Invasive ◽  
Gallbladder Cancer ◽  
Invasive Surgery ◽  
Open Surgery ◽  
Term Survival ◽  
Extended Cholecystectomy ◽  
Short And Long Term ◽  
Expert Center

In this article, we reviewed the techniques and outcomes of minimally invasive surgery for gallbladder cancer performed at an expert center. The techniques of laparoscopic extended cholecystectomy with the short- and long-term outcomes at our center were described. The short- and long-term survival outcomes of laparoscopic extended cholecystectomy are comparable to open surgery. Laparoscopic surgery is a safe, effective alternative for open surgery in the treatment of gallbladder cancer. The benefits of robotic surgery should be proven with further research.

Early outcomes of robotic extended cholecystectomy for the treatment of gallbladder cancer

2020 ◽  
Vol 27 (6) ◽  
pp. 324-330
Author(s):  
Yoonhyeong Byun ◽  
Yoo Jin Choi ◽  
Jae Seung Kang ◽  
Youngmin Han ◽  
Hongbeom Kim ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Extended Cholecystectomy

scholarly journals Identifying Cystic Vein Perfusion Area Employing Indocyanine Green Fluorescence Imaging during Laparoscopic Extended Cholecystectomy for Clinical T2 Gallbladder Cancer

2020 ◽  
Vol 14 (1) ◽  
pp. 110-115
Author(s):  
Akira Umemura ◽  
Hiroyuki Nitta ◽  
Takeshi Takahara ◽  
Yasushi Hasegawa ◽  
Hirokatsu Katagiri ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Gallbladder Cancer ◽  
Fluorescence Imaging ◽  
Histopathological Examination ◽  
Surgical Margin ◽  
Ventral Side ◽  
Hepatic Parenchyma ◽  
Indocyanine Green Fluorescence ◽  
Anterior Branch ◽  
Extended Cholecystectomy

We present an original surgical technique for identifying the perfusion area of the cystic vein with indocyanine green (ICG) fluorescence imaging and laparoscopic extended cholecystectomy with lymphadenectomy for a 56-year-old woman with diagnosis of clinical T2 gallbladder cancer (GBC). First, we encircled Calot’s triangle using the Glissonean approach from the ventral side of the gallbladder plate and then taped the hilar Glissonean pedicles; these were temporally clamped, and ICG was injected into the vein. The perfusion area of the cystic vein was scrutinized, specifically the stained area of the hepatic parenchyma was marked, and extended cholecystectomy was performed along the resection line. Subsequently, we performed lymphadenectomy of the hepatoduodenal ligament to complete the operation. A postoperative histopathological examination revealed moderately differentiated adenocarcinoma with pathological T1bN0M0. Although extended cholecystectomy is currently recommended for clinical T2 GBC, there is no consensus on the definition of the gallbladder bed, and the ideal extent of hepatic resection has, therefore, not yet been determined. In addition, gallbladder bed resection with 2–3 cm of surgical margin is an empirical procedure that lacks scientific verification. Regarding anatomical features, the cystic vein sometimes drains directly into the anterior branch of the portal vein, penetrating the gallbladder plate and Laennec’s capsule of the anterior Glissonean pedicle. To address this background, we have developed a technique to identify the perfusion area of the cystic vein to determine the extent of hepatic parenchyma that should be resected during laparoscopic extended cholecystectomy for clinical T2 GBC.

scholarly journals Clinical Profile and Management of Gall Bladder Cancer: Our Early Experience

2014 ◽  
Vol 3 (1) ◽  
pp. 27-30
Author(s):  
Sujit Kumar ◽  
Prakash Kafle ◽  
N Maharjan ◽  
BN Patowar ◽  
N Belbase ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Gall Bladder ◽  
Gallbladder Cancer ◽  
Gall Bladder Cancer ◽  
Clinical Profile ◽  
Medical Sciences ◽  
Single Institution ◽  
Palpable Mass ◽  
Medical College ◽  
Extended Cholecystectomy

Objective: To evaluate the clinical profile of patients with gallbladder cancer. Methodology: This is a single institution based retrospective study of patients with gallbladder cancer who presented at College of Medical Sciences and Teaching Hospital, Bharatpur, Chitwan, Nepal. Patients presenting during the two years period from August 2011 to July 2013 were reviewed. Result: Out of 12 patients, 9 were females (75%) and 3 were males (25%), showing female preponderance. Most of the patients (75%) were in age group of 51-70 years. Only one patient (8%) was below 50 years of age. Main symptom was pain associated with anorexia, nausea & vomiting. Major signs were palpable mass, hepatomegaly and jaundice. All the histopathological reports were adenocarcinoma. 8 patients (66.66%) presented with advanced disease and were managed with extended cholecystectomy followed by systemic chemotherapy. Conclusions: Prevalence of gall bladder cancer is higher in females in our series. Most of the patients were in fifth to seventh decade of life and presented in advanced stage. Gallbladder cancer showed association with gallstones. DOI: http://dx.doi.org/10.3126/jonmc.v3i1.10050 Journal of Nobel Medical College Vol.3(1) 2014; 27-30

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