Letter to the Editor Re: A population study of screening history and diagnostic outcomes of women with invasive cervical cancer

Objective. Audit of women with invasive cervical cancer (CC) is critical for quality control within screening activities. We analysed the screening history in the 10 years preceding the study entry in women with and without CC during 2000–2011.Methods. 323 women with CC from six pathology departments in Catalonia (Spain) and 23,782 women with negative cytology were compared. Age, previous history of cytologies, and histological type and FIGO stage were collected from the pathology registries. Logistic regression analysis was used to estimate odds ratios (OR) and 95% confidence intervals (CI95%).Results. History of cytology was registered in 26.2% of CC cases and in 78% of the control women (P<0.0001) and its frequency decreased with increasing age. Compared to women with squamous cell carcinoma, adenocarcinoma cases were significantly more likely to have a cytology within the 3-year interval preceding cancer diagnosis (OR=2.6CI 95%: 1.2–5.6) and to have normal cytology results in previous screenings (OR=2.4CI 95%: 1.2–4.5). FIGO II–IV cases were more common among older women (older than 60 years).Conclusions. Absence of prior screening history was extremely common among CC cases compared to controls. Organized actions to reduce underscreened women and use of highly sensitive HPV-based tests could be important to reduce CC burden.

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Screening history of women with invasive cervical cancer in north-east Italy

European Journal of Obstetrics & Gynecology and Reproductive Biology ◽

10.1016/j.ejogrb.2010.06.005 ◽

2010 ◽

Vol 152 (2) ◽

pp. 200-204 ◽

Cited By ~ 9

Author(s):

Antonella Zucchetto ◽

Silvia Franceschi ◽

Elena Clagnan ◽

Diego Serraino ◽

Loris Zanier ◽

...

Keyword(s):

Cervical Cancer ◽

Invasive Cervical Cancer ◽

North East ◽

History Of ◽

Screening History

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Screening history preceding and long-term risk of invasive cervical cancer following diagnosis of adenocarcinoma in situ in routine clinical practice

Gynecologic Oncology ◽

10.1016/j.ygyno.2011.12.147 ◽

2012 ◽

Vol 125 ◽

pp. S61-S62

Author(s):

H. Dinkelspiel ◽

B. Fetterman ◽

W. Kinney ◽

N. Poitras ◽

T. Lorey ◽

...

Keyword(s):

Cervical Cancer ◽

Clinical Practice ◽

Invasive Cervical Cancer ◽

Routine Clinical Practice ◽

Adenocarcinoma In Situ ◽

Screening History

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Screening history of women in Malmö with invasive cervical cancer

European Journal of Obstetrics & Gynecology and Reproductive Biology ◽

10.1016/j.ejogrb.2006.12.005 ◽

2008 ◽

Vol 137 (1) ◽

pp. 77-83 ◽

Cited By ~ 15

Author(s):

Pelle G. Lindqvist ◽

Charlotte Hellsten ◽

Amanda Rippe

Keyword(s):

Cervical Cancer ◽

Invasive Cervical Cancer ◽

History Of ◽

Screening History

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Screening History Among Women with Invasive Cervical Cancer in an Academic Medical Center: Will We Miss Cancers Following Updated Guidelines?

Journal of Women s Health ◽

10.1089/jwh.2015.5394 ◽

2016 ◽

Vol 25 (8) ◽

pp. 826-831 ◽

Cited By ~ 3

Author(s):

Caroline Nitschmann ◽

Taymaa May ◽

Jelena Mirkovic ◽

Sarah Feldman

Keyword(s):

Cervical Cancer ◽

Medical Center ◽

Academic Medical Center ◽

Invasive Cervical Cancer ◽

Academic Medical ◽

Screening History

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Frequent high-risk HPV co-infections excluding types 16 or 18 in cervical neoplasia in Guadeloupe

BMC Cancer ◽

10.1186/s12885-021-07940-3 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Stanie Gaete ◽

Aviane Auguste ◽

Bernard Bhakkan ◽

Jessica Peruvien ◽

Cecile Herrmann-Storck ◽

...

Keyword(s):

Cervical Cancer ◽

Invasive Cervical Cancer ◽

Population Based ◽

Multiple Infections ◽

French Caribbean ◽

Papilloma Virus ◽

Hpv Genotyping ◽

Hpv Status ◽

Hpv Genotypes ◽

High Risk Hpv

Abstract Background Cervical cancer is the fourth cancer worldwide. The Human Papilloma Virus is responsible for 99% of the cases but the distribution of its genotypes varies among populations. We aimed to identify HPV genotypes distribution in women with grade 2/3 cervical intraepithelial dysplasia or invasive cervical cancer in Guadeloupe, a French Caribbean territory with a population mainly of African descent. Methods We used paraffin-embedded tumors for viral DNA extraction from women diagnosed between 2014 and 2016 and identified by the population-based cancer registry. The HPV Genotyping was performed with the InnoLIPA HPV Genotyping Extra kit®. Results Overall, 213 samples out of the 321 eligible records were analyzed. The HPV status was positive for 94% of the cases. The five most common oncogenic HPV genotypes were HPV31 (47%), HPV33 (38%), HPV16 (32%), HPV44 (31%) and HPV26 (28%). HPV18 was found in only in 5% of the cases. Among the studied cases, 94% had multiple infections. More than 60% of single infections were HPV16-related, accounting for 35% of HPV16 infections. Conclusions These results show a different distribution of oncogenic HPVs in Guadeloupe with “31 > 33 > 16” and a high frequency of multiple infections. Despite a lower coverage, the nine-valent vaccine is nevertheless adequate.

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