The pro‐proliferative effect of insulin in human breast epithelial DMBA ‐transformed and non‐transformed cell lines is PI3K ‐, mTOR ‐ and GLUT1 ‐dependent

2022 ◽  
Author(s):  
Cláudia Silva ◽  
Nelson Andrade ◽  
João Tiago Guimarães ◽  
Emília Cardoso ◽  
Catarina Meireles ◽  
...  
Keyword(s):  
Cell Lines ◽  
Human Breast ◽  
Transformed Cell ◽  
Proliferative Effect ◽  
Breast Epithelial ◽  
Transformed Cell Lines

scholarly journals Effect of tunicamycin on cell growth and morphology of nontransformed and transformed cell lines.

1979 ◽  
Vol 43 (7) ◽  
pp. 1553-1561 ◽  
Author(s):  
Kenji KOHNO ◽  
Akiyoshi HIRAGUN ◽  
Hiromi MITSUI ◽  
Akira TAKATSUKI ◽  
Gakuzo TAMURA
Keyword(s):  
Cell Growth ◽  
Cell Lines ◽  
Transformed Cell ◽  
Transformed Cell Lines

scholarly journals G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA

2015 ◽  
Vol 209 (1) ◽  
pp. 73-84 ◽  
Author(s):  
Anaïs Aulas ◽  
Guillaume Caron ◽  
Christos G. Gkogkas ◽  
Nguyen-Vi Mohamed ◽  
Laurie Destroismaisons ◽  
...  
Keyword(s):  
Normal Stress ◽  
Cell Lines ◽  
Translational Repression ◽  
Primary Neurons ◽  
Processing Bodies ◽  
Transformed Cell ◽  
Upstream Regulator ◽  
Functional Consequences ◽  
Transformed Cell Lines ◽  
Polyadenylated Mrna

G3BP1, a target of TDP-43, is required for normal stress granule (SG) assembly, but the functional consequences of failed SG assembly remain unknown. Here, using both transformed cell lines and primary neurons, we investigated the functional impact of this disruption in SG dynamics. While stress-induced translational repression and recruitment of key SG proteins was undisturbed, depletion of G3BP1 or its upstream regulator TDP-43 disturbed normal interactions between SGs and processing bodies (PBs). This was concomitant with decreased SG size, reduced SG–PB docking, and impaired preservation of polyadenylated mRNA. Reintroduction of G3BP1 alone was sufficient to rescue all of these phenotypes, indicating that G3BP1 is essential for normal SG–PB interactions and SG function.

The preferential cytotoxicity of reovirus for certain transformed cell lines

1977 ◽  
Vol 54 (4) ◽  
pp. 307-315 ◽  
Author(s):  
G. Hashiro ◽  
P. C. Loh ◽  
Jenny T. Yau
Keyword(s):  
Cell Lines ◽  
Transformed Cell ◽  
Transformed Cell Lines

scholarly journals Antibiotic magainins exert cytolytic activity against transformed cell lines through channel formation.

1991 ◽  
Vol 88 (9) ◽  
pp. 3792-3796 ◽  
Author(s):  
R. A. Cruciani ◽  
J. L. Barker ◽  
M. Zasloff ◽  
H. C. Chen ◽  
O. Colamonici
Keyword(s):  
Cell Lines ◽  
Cytolytic Activity ◽  
Channel Formation ◽  
Transformed Cell ◽  
Transformed Cell Lines
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