scholarly journals Light-Controlled Cellular Internalization and Cytotoxicity of Nucleic Acid-Binding Agents: Studies in Vitro and in Zebrafish Embryos

ChemBioChem ◽  
2015 ◽  
Vol 17 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Cristina Penas ◽  
Mateo I. Sánchez ◽  
Jorge Guerra-Varela ◽  
Laura Sanchez ◽  
M. Eugenio Vázquez ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Zebrafish Embryos ◽  
Cellular Internalization ◽  
Nucleic Acid Binding ◽  
Binding Agents

Inside Cover: Light-Controlled Cellular Internalization and Cytotoxicity of Nucleic Acid-Binding Agents: Studies in Vitro and in Zebrafish Embryos (ChemBioChem 1/2016)

ChemBioChem ◽  
2016 ◽  
Vol 17 (1) ◽  
pp. 2-2
Author(s):  
Cristina Penas ◽  
Mateo I. Sánchez ◽  
Jorge Guerra-Varela ◽  
Laura Sanchez ◽  
M. Eugenio Vázquez ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Zebrafish Embryos ◽  
Cellular Internalization ◽  
Nucleic Acid Binding ◽  
Binding Agents

scholarly journals Nucleic acid binding agents exert local toxic effects on neurites via a non-nuclear mechanism

2006 ◽  
Vol 96 (5) ◽  
pp. 1253-1266 ◽  
Author(s):  
Sokhon Pin ◽  
Huiling Chen ◽  
Pamela J. Lein ◽  
Michael M. Wang
Keyword(s):  
Nucleic Acid ◽  
Toxic Effects ◽  
Nucleic Acid Binding ◽  
Binding Agents

ChemInform Abstract: Synthesis of Dicationic Diarylpyridines as Nucleic-Acid Binding Agents.

ChemInform ◽  
2010 ◽  
Vol 26 (31) ◽  
pp. no-no
Author(s):  
A. KUMAR ◽  
R. A. RHODES ◽  
J. SPYCHALA ◽  
W. D. WILSON ◽  
D. W. BOYKIN ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acid Binding ◽  
Binding Agents

scholarly journals In Vitro RNase and Nucleic Acid Binding Activities Implicate Coilin in U snRNA Processing

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e36300 ◽  
Author(s):  
Hanna J. Broome ◽  
Michael D. Hebert
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acid Binding

Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo

Science ◽  
1976 ◽  
Vol 193 (4253) ◽  
pp. 592-595 ◽  
Author(s):  
I. Weinstein ◽  
A. Jeffrey ◽  
K. Jennette ◽  
S. Blobstein ◽  
R. Harvey ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acid Binding ◽  
Diol Epoxides

scholarly journals The Gly/Arg-rich (GAR) domain of Xenopus nucleolin facilitates in vitro nucleic acid binding and in vivo nucleolar localization.

1993 ◽  
Vol 4 (11) ◽  
pp. 1189-1204 ◽  
Author(s):  
M A Heine ◽  
M L Rankin ◽  
P J DiMario
Keyword(s):  
Nucleic Acid ◽  
Binding Activity ◽  
Full Length ◽  
Nucleic Acid Binding ◽  
Binding Assays ◽  
Nucleic Acid Probes ◽  
E Coli ◽  
Indirect Immunofluorescence Staining

Epitope-tagged Xenopus nucleolin was expressed in Escherichia coli cells and in Xenopus oocytes either as a full-length wild-type protein or as a truncation that lacked the distinctive carboxy glycine/arginine-rich (GAR) domain. Both full-length and truncated versions of nucleolin were tagged at their amino termini with five tandem human c-myc epitopes. Whether produced in E. coli or in Xenopus, epitope-tagged full-length nucleolin bound nucleic acid probes in in vitro filter binding assays. Conversely, the E. coli-expressed GAR truncation failed to bind the nucleic acid probes, whereas the Xenopus-expressed truncation maintained slight binding activity. Indirect immunofluorescence staining showed that myc-tagged full-length nucleolin properly localized to the dense fibrillar regions within the multiple nucleoli of Xenopus oocyte nuclei. The epitope-tagged GAR truncation also translocated to the oocyte nuclei, but it failed to efficiently localize to the nucleoli. Our results show that the carboxy GAR domain must be present for nucleolin to efficiently bind nucleic acids in vitro and to associate with nucleoli in vivo.

scholarly journals Atomic model of human Rcd-1 reveals anarmadillo-like-repeat protein with in vitro nucleic acid binding properties

2007 ◽  
Vol 16 (2) ◽  
pp. 176-188 ◽  
Author(s):  
Robert G. Garces ◽  
Wanda Gillon ◽  
Emil F. Pai
Keyword(s):  
Nucleic Acid ◽  
Atomic Model ◽  
Nucleic Acid Binding ◽  
Binding Properties ◽  
Repeat Protein

Nucleic-acid-binding properties of hnRNP-U/SAF-A, a nuclear-matrix protein which binds DNA and RNA in vivo and in vitro

1994 ◽  
Vol 221 (2) ◽  
pp. 749-757 ◽  
Author(s):  
Frank O. FACKELMAYER ◽  
Kirsten DAHM ◽  
Andrea RENZ ◽  
Uwe RAMSPERGER ◽  
Arndt RICHTER
Keyword(s):  
Nucleic Acid ◽  
Nuclear Matrix ◽  
Matrix Protein ◽  
Nucleic Acid Binding ◽  
Nuclear Matrix Protein ◽  
Binding Properties ◽  
Dna And Rna ◽  
Hnrnp U
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