EGF domain of coagulation factor IX is conducive to exposure of phosphatidylserine

2017 ◽  
Vol 41 (4) ◽  
pp. 374-383 ◽  
Author(s):  
Chiaki Hidai ◽  
Yusuke Fujiwara ◽  
Shinichiro Kokubun ◽  
Hisataka Kitano
Keyword(s):  
Coagulation Factor ◽  
Factor Ix ◽  
Coagulation Factor Ix ◽  
Egf Domain

scholarly journals The first EGF domain of coagulation factor IX attenuates cell adhesion and induces apoptosis

2016 ◽  
Vol 36 (3) ◽  
Author(s):  
Tomomi Ishikawa ◽  
Hisataka Kitano ◽  
Atsushi Mamiya ◽  
Shinichiro Kokubun ◽  
Chiaki Hidai
Keyword(s):  
Extracellular Matrix ◽  
Cell Adhesion ◽  
Growth Factor ◽  
Caspase 3 ◽  
Coagulation Factor ◽  
Factor Ix ◽  
Coagulation Factor Ix ◽  
Epidermal Growth ◽  
Egf Domain ◽  
Induced Apoptosis

Activated coagulation factor IX (FIX) attenuated cell adhesion to the extracellular matrix (ECM) and induced apoptosis. This activity was localized to the first epidermal growth factor (EGF) domain, EGF-F9. Experiments with caspase-3 inhibitors revealed that attenuation of adhesion and apoptosis by EGF-F9 were dependent on caspase-3.

scholarly journals Results of a phase I/II open‐label, safety and efficacy trial of coagulation factor IX (recombinant), albumin fusion protein in haemophilia B patients

Haemophilia ◽  
2015 ◽  
Vol 21 (6) ◽  
pp. 784-790 ◽  
Author(s):  
U. Martinowitz ◽  
T. Lissitchkov ◽  
A. Lubetsky ◽  
G. Jotov ◽  
T. Barazani‐Brutman ◽  
...  
Keyword(s):  
Fusion Protein ◽  
Phase I ◽  
Coagulation Factor ◽  
Factor Ix ◽  
Efficacy Trial ◽  
Open Label ◽  
Safety And Efficacy ◽  
Haemophilia B ◽  
Coagulation Factor Ix

Recombinant Coagulation Factor IX

1998 ◽  
Vol 89 (3) ◽  
pp. 147-150 ◽  
Author(s):  
Bernhard E Fischer ◽  
Friedrich Dorner
Keyword(s):  
Coagulation Factor ◽  
Factor Ix ◽  
Coagulation Factor Ix
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