microRNA‐340‐5p increases telomere length by targeting telomere protein POT1 to improve Alzheimer disease in mice

2021 ◽  
Author(s):  
Xin li ◽  
Jiangkuan Zhang ◽  
Yuhang Yang ◽  
Qi Wu ◽  
Hanbing Ning
Keyword(s):  
Alzheimer Disease ◽  
Telomere Length ◽  
Telomere Protein

scholarly journals Telomere Length Shortening and Alzheimer Disease—A Mendelian Randomization Study

2015 ◽  
Vol 72 (10) ◽  
pp. 1202 ◽  
Author(s):  
Yiqiang Zhan ◽  
Ci Song ◽  
Robert Karlsson ◽  
Annika Tillander ◽  
Chandra A. Reynolds ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Telomere Length ◽  
Mendelian Randomization

scholarly journals UFMylation of MRE11 is essential for maintenance of telomere length and hematopoietic stem cell survival

2019 ◽  
Author(s):  
Lara Lee ◽  
Ana Belen Perez Oliva ◽  
Dmitri Churikov ◽  
Elena Martinez-Balsalobre ◽  
Joshua Peter ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Telomere Length ◽  
Hematopoietic Stem Cell ◽  
Strand Break ◽  
Telomere Maintenance ◽  
Hematopoietic Stem ◽  
Telomere Protein ◽  
Stem Cell Survival

AbstractGenetic studies using knockout mouse models provide strong evidence for the essential role of the ubiquitin-like protein UFM1 for hematopoiesis, especially erythroid development, yet its biological roles in this process are largely unknown. Here we have identified a UFL1-dependent UFMylation of the MRE11 nuclease on the K281 and K282 residues. We show that Hela cells lacking the specific UFM1 E3 ligase display severe telomere shortening. We further demonstrate either by deleting UFM1 or by mutating MRE11 UFMylation sites that preventing MRE11 UFMylation impacts its interaction with the telomere protein TRF2. However, the MRE11 function in double-strand-break repair remains intact. We validate these results in vivo by showing that Zebrafish knockouts for the genes ufl1 and ufm1 have shorter telomeres in hematopoietic cells. Here we present UFMylation has a new mechanisms of regulation for telomere length maintenance with a role in hematopoiesis.Key pointsModification of MRE11 by UFM1 regulates telomere maintenance and cell death in HSCsScientific categoryUFMylation, telomere maintenance, hematopoietic stem cell survival.

scholarly journals Telomere length and 8-hydroxy-2-deoxyguanosine as markers for early prediction of Alzheimer disease

2020 ◽  
Vol 62 (6) ◽  
pp. 678
Author(s):  
AmrS Shalaby ◽  
DaliaH Abou-Elela ◽  
RawhiaH El-Edel ◽  
MariamA Fouaad ◽  
AhmedA Sonbol
Keyword(s):  
Alzheimer Disease ◽  
Telomere Length ◽  
Early Prediction

Structural and Chemical Studies of Pathological Fibers in Human Neurofibrillary Degeneration

1985 ◽  
Vol 43 ◽  
pp. 726-729
Author(s):  
K.S. Kosik ◽  
L.K. Duffy ◽  
S. Bakalis ◽  
C. Abraham ◽  
D.J. Selkoe
Keyword(s):  
Monoclonal Antibodies ◽  
Alzheimer Disease ◽  
Human Brain ◽  
Neurofibrillary Tangles ◽  
Morphological Analysis ◽  
High Specificity ◽  
Cytoskeletal Proteins ◽  
Neuritic Plaque ◽  
Protein Chemistry ◽  
Chemical Studies

The major structural lesions of the human brain during aging and in Alzheimer disease (AD) are the neurofibrillary tangles (NFT) and the senile (neuritic) plaque. Although these fibrous alterations have been recognized by light microscopists for almost a century, detailed biochemical and morphological analysis of the lesions has been undertaken only recently. Because the intraneuronal deposits in the NFT and the plaque neurites and the extraneuronal amyloid cores of the plaques have a filamentous ultrastructure, the neuronal cytoskeleton has played a prominent role in most pathogenetic hypotheses.The approach of our laboratory toward elucidating the origin of plaques and tangles in AD has been two-fold: the use of analytical protein chemistry to purify and then characterize the pathological fibers comprising the tangles and plaques, and the use of certain monoclonal antibodies to neuronal cytoskeletal proteins that, despite high specificity, cross-react with NFT and thus implicate epitopes of these proteins as constituents of the tangles.

Caregivers' burden of women as family member of elders with Alzheimer disease

2012 ◽  
Author(s):  
Farideh Bastani
Keyword(s):  
Alzheimer Disease ◽  
Family Member

Sensory Motor Tasks in Identification of Alzheimer Disease Using CART

2009 ◽  
Author(s):  
Anya Mazur-Mosiewicz ◽  
Matthew J. Holcomb ◽  
Raymond S. Dean
Keyword(s):  
Alzheimer Disease ◽  
Motor Tasks ◽  
Sensory Motor

Potassium-Sparing Diuretics Associated With Decreased Risk of Alzheimer Disease

2006 ◽  
Author(s):  
A. Khachaturian ◽  
P. Zandi ◽  
C. G. Lyketsos ◽  
K. M. Hayden ◽  
I. Skoog ◽  
...  
Keyword(s):  
Alzheimer Disease

Alzheimer disease and protein turnover: A GlcNAc trick

2008 ◽  
Author(s):  
Mirko von Elstermann
Keyword(s):  
Alzheimer Disease ◽  
Protein Turnover
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