scholarly journals Cyclin‐Dependent Kinase 4 expression alters the number of keratinocyte stem cells in the mouse hair follicle

2022 ◽  
Author(s):  
Sun Hye Kim ◽  
Liliana R. L. Rodriguez ◽  
Everardo Macias ◽  
Marcelo L. Rodriguez‐Puebla
Keyword(s):  
Stem Cells ◽  
Hair Follicle ◽  
Cyclin Dependent Kinase ◽  
Keratinocyte Stem Cells

scholarly journals In Vitro Differences Between Keratinocyte Stem Cells and Transit-Amplifying Cells of the Human Hair Follicle

2005 ◽  
Vol 125 (6) ◽  
pp. 1099-1105 ◽  
Author(s):  
Cecilia Roh ◽  
Qingfeng Tao ◽  
Christos Photopoulos ◽  
Stephen Lyle
Keyword(s):  
Stem Cells ◽  
Hair Follicle ◽  
Human Hair ◽  
Human Hair Follicle ◽  
Keratinocyte Stem Cells

Dermal papilla-induced hair differentiation of adult epithelial stem cells from human skin

2004 ◽  
Vol 19 (2) ◽  
pp. 207-217 ◽  
Author(s):  
Cecilia Roh ◽  
Qingfeng Tao ◽  
Stephen Lyle
Keyword(s):  
Stem Cells ◽  
Hair Follicle ◽  
Cell Fate ◽  
Time Course ◽  
Dermal Papilla ◽  
Fold Increase ◽  
Keratinocyte Differentiation ◽  
Epithelial Stem Cells ◽  
High Calcium ◽  
Keratinocyte Stem Cells

The epithelial-mesenchymal interactions between keratinocyte stem cells and dermal papilla (DP) cells are crucial for normal development of the hair follicle as well as during hair cycling. During the cyclical regrowth of a new lower follicle, the multipotent hair follicle stem cells are stimulated to proliferate and differentiate through interactions with the underlying mesenchymal DP cells. To characterize the events occurring during the process of epithelial stem cell fate determination, we utilized a coculture system by incubating human hair follicle keratinocyte stem cells with DP cells. Using GeneChip microarrays, we analyzed changes in gene expression within the stem cells upon coculture with the DP over a 5-day time course. A number of important signaling pathways and growth factors were regulated. The hair-specific keratin 6hf (K6hf) gene proved a particularly good marker of hair differentiation, with a 7.9-fold increase in mRNA and resulting increased protein levels. The high expression of K6hf was unique to DP-induced keratinocyte differentiation, since expression of K6hf was not induced by high calcium. Since the β-catenin signaling pathway has been implicated in hair follicle development, we examined the role of β-catenin in our system and demonstrated that β-catenin/lef-1 signaling is required for DP-induced hair differentiation.

Abstract 3889: Cyclin-dependent kinase 4 levels affect the number of hair follicle stem cells in mouse epidermis

2010 ◽  
Author(s):  
Sun Hye Kim ◽  
Everardo Macías ◽  
Christopher Sistrunk ◽  
Marcelo L. Rodriguez-Puebla
Keyword(s):  
Stem Cells ◽  
Hair Follicle ◽  
Cyclin Dependent Kinase ◽  
Mouse Epidermis ◽  
Hair Follicle Stem Cells ◽  
Follicle Stem Cells

Keratinocyte stem cells of cornea, skin and hair follicle: common and distinguishing features

1993 ◽  
Vol 4 (4) ◽  
pp. 217-240 ◽  
Author(s):  
Stanley J. Miller ◽  
Robert M. Lavker ◽  
Tung-Tien Sun
Keyword(s):  
Stem Cells ◽  
Hair Follicle ◽  
Distinguishing Features ◽  
Keratinocyte Stem Cells

In Vitro Proliferation and Differentiation of Human Hair Follicle Stem Cells on Chitosan-Skin Regenerating Template

2015 ◽  
Vol 05 (999) ◽  
pp. 1-1
Author(s):  
Abu Bakar Mohd Hilmi ◽  
Mohd Noor Norhayati ◽  
Ahmad Sukari Halim ◽  
Chin Keong Lim ◽  
Zulkifli Mustafa ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hair Follicle ◽  
Human Hair ◽  
Human Hair Follicle ◽  
In Vitro Proliferation ◽  
Proliferation And Differentiation ◽  
Hair Follicle Stem Cells ◽  
Follicle Stem Cells
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