scholarly journals Adenocarcinoma of intestinal type arising in mature cystic teratoma of ovary: A diagnostic dilemma

2020 ◽  
Vol 8 (4) ◽  
pp. 644-647
Author(s):  
Imtinene Belaid ◽  
Wiem Khechine ◽  
Atef Ben Abdelkader ◽  
Ahlem Bedioui ◽  
Faten Ezzairi ◽  
...  
Keyword(s):  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Intestinal Type ◽  
Diagnostic Dilemma

scholarly journals Mucinous adenocarcinoma of the intestinal type arising from mature cystic teratoma of the ovary: a rare case report and review of the literature

2012 ◽  
Vol 5 (1) ◽  
pp. 41 ◽  
Author(s):  
Masaaki Takai ◽  
Masanori Kanemura ◽  
Hiroshi Kawaguchi ◽  
Satoe Fujiwara ◽  
Saha Yoo ◽  
...  
Keyword(s):  
Case Report ◽  
Mucinous Adenocarcinoma ◽  
Rare Case ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Intestinal Type ◽  
Review Of The Literature ◽  
Rare Case Report

Mature cystic teratoma arising at the porta hepatis: a diagnostic dilemma

2008 ◽  
Vol 43 (4) ◽  
pp. e1-e3 ◽  
Author(s):  
Bazil Brown ◽  
Basem Khalil ◽  
Gauri Batra ◽  
Barbara Rampersad ◽  
James Bruce
Keyword(s):  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Porta Hepatis ◽  
Diagnostic Dilemma

scholarly journals A case of mature cystic teratoma with intestinal structures harboring intestinal-type low-grade mucinous neoplasm

2018 ◽  
Vol 7 (2) ◽  
pp. 59-64
Author(s):  
Maki Takao ◽  
Yasunori Yoshino ◽  
Ayumi Taguchi ◽  
Masaya Uno ◽  
Satoshi Okada ◽  
...  
Keyword(s):  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Intestinal Type ◽  
Low Grade ◽  
Mucinous Neoplasm

scholarly journals Ovarian mature cystic teratoma with malignant transformation: two case reports

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Afsaneh Tehranian ◽  
Akram Ghahghaei-Nezamabadi ◽  
Akram Seifollahi ◽  
Sara Kasraei ◽  
Hamideh Dehghani-Nejad ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Case Reports ◽  
Cystic Teratoma ◽  
Good Prognosis ◽  
Mature Cystic Teratoma ◽  
Treatment Protocols ◽  
Large Size ◽  
Stage Ia ◽  
Loss Of Appetite ◽  
Case Number

Abstract Background Mature Cystic Teratoma (MCT) is a benign tumor that can lead to malignant transformation (MT) in 1–3% of cases. Management of MT is a big challenge for gynecologic oncologists due to the lack of specific diagnostic and treatment protocols. Case presentation We reported two Iranian cases of MT of MCT with two different stages and prognosis. Our both cases presented the same symptoms, including chronic abdominal pain and distention, loss of appetite, and weight loss. In case number 1, despite the large size of the tumor, the disease was at stage Ia and had a good prognosis; while, case number 2 was at stage IIIc of the disease with a poor prognosis. Conclusion The stage of the disease is the most important prognostic factor, and early diagnosis and treatment are very critical for better survival.

scholarly journals Genetic Profiling of Malignant Melanoma Arising from an Ovarian Mature Cystic Teratoma: A Case Report

2021 ◽  
Vol 22 (5) ◽  
pp. 2436
Author(s):  
Kohei Nakamura ◽  
Eriko Aimono ◽  
Reika Takamatsu ◽  
Shigeki Tanishima ◽  
Tomonari Tohyama ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Malignant Tumors ◽  
Cystic Teratoma ◽  
Homozygous Deletion ◽  
Mature Cystic Teratoma ◽  
Genetic Profiling ◽  
Improve Treatment ◽  
The Status ◽  
Genetic Mechanisms ◽  
Targeted Gene Sequencing

Ovarian mature cystic teratomas comprise tissues derived from all three germ layers. In rare cases, malignant tumors arise from ovarian mature cystic teratoma. A variety of tumors can arise from mature cystic teratoma, among which primary malignant melanoma (MM), for which no molecular analyses such as genomic sequencing have been reported to date, is exceedingly rare, thereby limiting possible therapeutic options using precision medicine. We used targeted gene sequencing to analyze the status of 160 cancer-related genes in a patient with MM arising from an ovarian mature cystic teratoma (MM-MCT). KRAS amplification and homozygous deletion in PTEN and RB1 were detected in tumor samples collected from the patient. No KRAS amplification has been previously reported in cutaneous MM, indicating that the carcinogenesis of MM-MCT differs from that of primary cutaneous melanomas. A better understanding of the underlying genetic mechanisms will help clarify the carcinogenesis of MM-MCT. In turn, this will enable treatment with novel targeting agents as well as the initial exploration of gene-based precision oncological therapies, which aim to improve treatment outcomes for patients with this disease.

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