mucinous cystadenocarcinoma
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2021 ◽  
Author(s):  
Zhenyu Li ◽  
Qingming Jiang ◽  
Dongfang Guo ◽  
Yong Cao ◽  
Yangling Peng ◽  
...  

Abstract Background: Mucinous cystadenocarcinoma of the breast is a very rare and special type adenocarcinoma of the mammary tract. We report a rare case of mucinous cystadenocarcinoma of the breast with an unfavourable prognosis which was confirmed after surgical resection pathologically. Case summary: At low power appearance, the tumor formed mucus-filled spaces of varying sizes, and with mucus-rich tumor cells lining the walls. The tumor cells were arranged in papillary structures. At high magnification, the tumor cells shown moderate to severe atypia, which were most of simple columnar cells with nuclei in the base and cytoplasm rich in mucin. In some areas, tumor cells proliferated, stratified, and clustered that protruded into the cyst cavity, or formed papillary structures with thin fibrovascular core. Immunohistochemical staining showed cytoplasm CK7 strong positive of tumor cells and cytoplasm negative of CK20, PAX-8 and CDX2, which could exclude metastatic tumors from ovary and intestine. And the tumor cells also demonstrated the basal-like characters such as negative for ER, PR, HER-2 (triple-negative), CK5/6 focal positive, EGFR positive. Besides, a triple negative breast cancer with basal-like features, lymph node, thoracic wall metastasis of mucinous cystadenocarcinoma was found. Conclusion: Mucinous cystadenocarcinoma of the breast usually have a favorable prognosis, but in this case, it happened lymph node, thoracic wall metastasis, therefore, it needs extra attention of clinical workers.


2021 ◽  
Vol 14 (7) ◽  
pp. e242478
Author(s):  
Claire Filippini ◽  
Sarah Smyth ◽  
Hooman Soleymani Majd ◽  
Catherine Johnson

We present the case of a 32-year-old woman with a previous surgical history of benign mucinous cystadenoma resected in 2012 who underwent magnetic resonance cholangiopancreatography following her second pregnancy in 2020. This demonstrated a large cystic mass in the left subdiaphragmatic space. Histopathology confirmed a well-differentiated primary peritoneal mucinous cystadenocarcinoma displaying cells of a Mullerian origin. We subsequently discuss the aetiology of these conditions separately and explore the possibility of a connection between the two regarding origin or potential malignant transformation that may otherwise have occurred coincidentally in this young patient. We also acknowledge a paucity of evidence regarding subsequent management strategies.


2021 ◽  
Author(s):  
Lawrence Hsu Lin ◽  
Osvaldo Hernandez ◽  
Kelsey Zhu ◽  
Amber Guth ◽  
Paolo Cotzia ◽  
...  

2021 ◽  
Vol 37 (1) ◽  
pp. 43-46
Author(s):  
Jung Hwan Um ◽  
Dong In Jo ◽  
Soon Heum Kim

Suizo ◽  
2021 ◽  
Vol 36 (2) ◽  
pp. 142-149
Author(s):  
Rei TAKAHASHI ◽  
Hideki SASANUMA ◽  
Eriko IKEDA ◽  
Atsushi MIKI ◽  
Kazue MORISHIMA ◽  
...  

2021 ◽  
Vol 23 (5) ◽  
Author(s):  
Xiaobo Peng ◽  
Chengtao Guo ◽  
Yanjun Wu ◽  
Mingzhen Ying ◽  
Renxu Chang ◽  
...  

2021 ◽  
Author(s):  
Hajar Abbasi ◽  
Saloomeh Mohammadi ◽  
Atefeh Moridi ◽  
Athena Behforouz

Most adnexal masses found in pregnancy are simple benign cysts less than 5 cm in diameter. On the other hand, the majority of persistent adnexal masses 5 cm or greater in diameter are mature teratomas. Malignant transformation occurs in 0.2 to 2 percent of mature teratomas, and squamous cell carcinoma arising from ectoderm is the most common secondary neoplasm. The mucinous cystadenocarcinoma transformation is very rare. We presented a 38-year-old G2Ab1 woman at 32 weeks of gestation with a huge, rapid growth adnexal mass who came to our emergency department due to severe preeclampsia, stage 1 of IUGR, and borderline AFI. After 48 hours of expectant management, a cesarean section associated with unilateral salpingooophorectomy was done, and the histopathology of the cyst revealed mature teratoma that was focally involved with mucinous cystadenocarcinoma. The complete surgical staging was done, and due to the stage of disease (1C1), she received adjuvant chemotherapy, and she has remained disease-free in her last follow up after one year.


2021 ◽  
pp. 106689692199165
Author(s):  
Ekta Jain ◽  
Abhishek Kumar ◽  
Raajul Jain ◽  
Shivani Sharma

Primary mucinous cystadenocarcinoma (MCA) of the breast is a rare variant of breast carcinoma known to have a favorable prognosis despite showing a basal-like phenotype. We describe a case of MCA breast in a 45-year-old female with a palpable mass in the breast. On the basis of the histopathological and immunohistochemical evaluation of a lumpectomy specimen with the absence of mass anywhere else on whole-body imaging, a diagnosis of primary MCA was rendered. Mismatch repair protein evaluation showed this tumor to be microsatellite stable. Molecular testing revealed the absence of Kirsten rat sarcoma viral oncogene homolog (KRAS), neuroblastoma RAS viral oncogene homolog (NRAS), and v-raf murine sarcoma viral oncogene homolog B1 (BRAF) mutations. To date only 27 cases of MCA breast have been reported. To the best of our knowledge, ours is the first case documenting diffuse Cytokeratin 20 (CK20) positivity, microsatellite stability, and the absence of KRAS, NRAS, and BRAF mutations in these tumors. The rarity of this tumor further evokes an interest in this case. A better understanding of the disease warrants a review of more cases with longer follow-ups.


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