scholarly journals Recombinant activated factor VII in a patient with intracranial hemorrhage and severe thrombocytopenia

2021 ◽  
Vol 9 (10) ◽  
Author(s):  
Amir M. Ansari ◽  
Adam Khorasanchi ◽  
Armaghan Faghihimehr ◽  
Amir Toor
Keyword(s):  
Intracranial Hemorrhage ◽  
Factor Vii ◽  
Severe Thrombocytopenia ◽  
Recombinant Activated Factor Vii ◽  
Activated Factor Vii

Effects of Recombinant Activated Factor VII in Traumatic Nonsurgical Intracranial Hemorrhage

2006 ◽  
Vol 63 (5) ◽  
pp. 310-317 ◽  
Author(s):  
Christopher E. White ◽  
Amber E. Schrank ◽  
Toney W. Baskin ◽  
John B. Holcomb
Keyword(s):  
Intracranial Hemorrhage ◽  
Factor Vii ◽  
Recombinant Activated Factor Vii ◽  
Activated Factor Vii

scholarly journals Case Report: Factor VII Deficiency Presented With Cephalohematoma After Birth

2021 ◽  
Vol 9 ◽  
Author(s):  
Yuan-Chun Lo ◽  
Ching-Tien Peng ◽  
Yin-Ting Chen
Keyword(s):  
Replacement Therapy ◽  
Intracranial Hemorrhage ◽  
Hypovolemic Shock ◽  
Rehabilitation Program ◽  
Factor Vii ◽  
High Dose ◽  
Homozygous Mutation ◽  
Recombinant Activated Factor Vii ◽  
Factor Vii Deficiency ◽  
Activated Factor Vii

Introduction: Factor VII deficiency is a rare inherited autosomal recessive bleeding disorder with a global prevalence of 1/500,000. Most cases remain asymptomatic, and cases with severe clinical presentation are rarely reported.Case Presentation: A newborn male with no relevant maternal antenatal history, delivered via vacuum-assisted cesarean section, presented with a large cephalohematoma after delivery. Poor appetite, pale appearance, and bulging fontanelles were observed 2 days later, progressing to hypovolemic shock. Further imaging examination revealed a large intracranial hemorrhage. Serial laboratory examination revealed remarkable coagulopathy with prolonged prothrombin time and factor VII deficiency (<1%, severe type). The patient was genetically confirmed to have the FVII:c 681+1 G>T homozygous mutation. Brain hemorrhage was resolved with high-dose factor VII replacement therapy with recombinant activated factor VII. However, repeated hemothorax and intracranial hemorrhage were detected. Therefore, the patient was under regular factor VII supplementation with a rehabilitation program for cerebral palsy.Conclusions: A case of factor VII deficiency with large cephalohematoma and intracranial hemorrhage after birth is described herein, which was treated with high-dose replacement therapy. Variants of the FVII:c 681+1 G>T (IVS6+1G>T) homozygous genotype may present with a severe phenotype at the neonatal stage. We aim to share a unique neonatal presentation with a certain genotype and treatment experience with initial replacement therapy, followed by regular prophylactic dosage.

Recombinant activated factor VII (rFVIIa) therapy for intracranial hemorrhage in hemophilia a patients with inhibitors

1994 ◽  
Vol 47 (1) ◽  
pp. 36-40 ◽  
Author(s):  
M. L. Schmidt ◽  
S. Gamerman ◽  
H. E. Smith ◽  
J. P. Scott ◽  
D. M. DiMichele
Keyword(s):  
Intracranial Hemorrhage ◽  
Hemophilia A ◽  
Factor Vii ◽  
Recombinant Activated Factor Vii ◽  
Activated Factor Vii

Treatment of Warfarin-Related Intracranial Hemorrhage: A Comparison of Prothrombin Complex Concentrate and Recombinant Activated Factor VII

2010 ◽  
Vol 74 (6) ◽  
pp. 631-635 ◽  
Author(s):  
Nathan A. Pinner ◽  
April C. Hurdle ◽  
Carrie Oliphant ◽  
Anne Reaves ◽  
Bob Lobo ◽  
...  
Keyword(s):  
Intracranial Hemorrhage ◽  
Prothrombin Complex Concentrate ◽  
Factor Vii ◽  
Recombinant Activated Factor Vii ◽  
Activated Factor Vii
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