scholarly journals Effect of orotic acid addition on hydrolysis conversion of α‐tricalcium phosphate to hydroxyapatite

2021 ◽  
Author(s):  
Iori Yamada ◽  
Tania Guadalupe Peñaflor Galindo ◽  
Daichi Noda ◽  
Motohiro Tagaya
Keyword(s):  
Tricalcium Phosphate ◽  
Orotic Acid ◽  
Acid Addition

Production of Fatty Liver with Dietary Ethanol Despite Orotic Acid Supplementation

1974 ◽  
Vol 35 (1) ◽  
pp. 20-25 ◽  
Author(s):  
Juan G. Edreira ◽  
Robert L. Hirsch ◽  
James A. Kennedy
Keyword(s):  
Fatty Liver ◽  
Orotic Acid ◽  
Acid Supplementation

CONTRIBUTION TO THE EXISTENCE OF REGULATORY MECHANISMS AT THE ADRENAL LEVEL

1972 ◽  
Vol 70 (4) ◽  
pp. 741-757
Author(s):  
Otto Linèt
Keyword(s):  
Orotic Acid ◽  
Adrenal Glands ◽  
Actinomycin D ◽  
Delay Period ◽  
Regulatory Mechanisms ◽  
Leucine Incorporation ◽  
Total Period ◽  
Free Media

ABSTRACT Rat adrenal glands atrophied by the administration of cortisol acetate in vivo were used as a model for the study of early metabolic processes occurring in vitro. Atrophied adrenals incubated in the presence of 14C-leucine incorporated subnormal quantities of this amino acid per mg of protein for the first 120 min. When the incubation lasted for a total period of 180 or 240 min a supranormal rise in the 14C-leucine incorporation was observed. Similar changes occurred with some delay with regard to corticosterone production as expressed per 100 mg of tissue. No differences in 14C-leucine incorporation were observed between the control and atrophied adrenals in vivo. Homogenates from atrophied glands incorporated 14C-leucine to a greater extent than the control homogenates. The in vitro incorporation of 14C-orotic acid into the RNA was also higher in atrophied adrenals. The in vitro use of actinomycin D, cycloheximide and amphenone indicated that corticosterone production depended on the incorporation of 14C-leucine. The addition of cortisol to the incubation media markedly decreased the enhancement of 14C-lysine incorporation into the protein of atrophied adrenals. These, as well as additional results suggest rebound phenomena: once atrophic adrenals are transferred to cortisol-free media, reparative processes begin after a delay period. Such phenomena seem to be mediated by regulatory mechanisms at the adrenal level.

Bone regeneration after implantation of composite biomaterial based on polylactide, hydroxylapathite and tricalcium phosphate

2018 ◽  
Vol 2018 (2) ◽  
pp. 65-69
Author(s):  
O. M. Khvisiuk ◽  
◽  
O. D. Pavlov ◽  
V. V. Pastukh ◽  
◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate

Composite Materials in the Zirconia-Tricalcium Phosphate System for Bone Implants

2018 ◽  
Vol 483 (1) ◽  
pp. 59-63
Author(s):  
V. Smirnov ◽  
◽  
M. Goldberg ◽  
A. Krylov ◽  
S. Smirnov ◽  
...  
Keyword(s):  
Composite Materials ◽  
Tricalcium Phosphate ◽  
Bone Implants ◽  
Phosphate System

The Sintering Behaviour and Mechanical Properties of Hydroxyapatite - Based Composites for Bone Tissue Regeneration

2018 ◽  
Vol 69 (5) ◽  
pp. 1272-1275 ◽  
Author(s):  
Camelia Tecu ◽  
Aurora Antoniac ◽  
Gultekin Goller ◽  
Mustafa Guven Gok ◽  
Marius Manole ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tricalcium Phosphate ◽  
Cosmetic Surgery ◽  
Mechanical Stability ◽  
Raw Materials ◽  
Oyster Shell ◽  
Bone Tissue Regeneration ◽  
Sintering Behavior ◽  
Bovine Bone ◽  
Human Teeth

Bone reconstruction is a complex process which involves an osteoconductive matrix, osteoinductive signaling, osteogenic cells, vascularization and mechanical stability. Lately, to improve the healing of the bone defects and to accelerate the bone fusion and bone augmentation, bioceramic composite materials have been used as bone substitutes in the field of orthopedics and dentistry, as well as in cosmetic surgery. Of all types of bioceramics, the most used is hydroxyapatite, because of its similar properties to those of the human bone and better mechanical properties compared to b-tricalcium phosphate [1]. Currently, the most used raw materials sources for obtaining the hydroxyapatite are: bovine bone, seashells, corals, oyster shell, eggshells and human teeth. There are two common ways to obtain hydroxyapatite: synthetically and naturally. Generally, for the improvement of the mechanical properties and the structural one, hydroxyapatite is subjected to the sintering process. Considering the disadvantages of hydroxyapatite such as poor biodegradation rate, b-TCP has been developed, which has some disadvantages too, such as brittleness. For this reason, the aim of this study is to look into the effect of adding magnesium oxide on the sintering behavior, the structure and the mechanical properties of the hydroxyapatite-tricalcium phosphate composites.

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