Cover Picture: Total Synthesis of Leupyrrins A1
 and B1
, Highly Potent Antifungal Agents from the Myxobacterium Sorangium cellulosum
 (Chem. Eur. J. 14/2017)

The bengazoles are marine natural products with unique structure, containing two oxazole rings flanking a single carbon. They show very potent antifungal activity. The total syntheses of bengazole C and E are described following a convergent route which involves diastereoselective cycloaddition of an appropriately substituted nitrile oxide with a butane-1,2-diacetal-protected alkenediol as the key step.

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Corrigendum: Isolation and Total Synthesis of Icumazoles and Noricumazoles-Antifungal Antibiotics and Cation-Channel Blockers from Sorangium cellulosum

Angewandte Chemie International Edition ◽

10.1002/anie.201201953 ◽

2012 ◽

Vol 51 (25) ◽

pp. 6035-6035

Author(s):

Jenny Barbier ◽

Rolf Jansen ◽

Herbert Irschik ◽

Stefan Benson ◽

Klaus Gerth ◽

...

Keyword(s):

Total Synthesis ◽

Cation Channel ◽

Channel Blockers ◽

Sorangium Cellulosum ◽

Antifungal Antibiotics

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Isolation and Total Synthesis of Icumazoles and Noricumazoles-Antifungal Antibiotics and Cation-Channel Blockers from Sorangium cellulosum

Angewandte Chemie International Edition ◽

10.1002/anie.201106435 ◽

2011 ◽

Vol 51 (5) ◽

pp. 1256-1260 ◽

Cited By ~ 21

Author(s):

Jenny Barbier ◽

Rolf Jansen ◽

Herbert Irschik ◽

Stefan Benson ◽

Klaus Gerth ◽

...

Keyword(s):

Total Synthesis ◽

Cation Channel ◽

Channel Blockers ◽

Sorangium Cellulosum ◽

Antifungal Antibiotics

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ChemInform Abstract: Total Synthesis of the Potent Antifungal Agents Bengazole C and E.

ChemInform ◽

10.1002/chin.200946208 ◽

2009 ◽

Vol 40 (46) ◽

Author(s):

Alvaro Enriquez-Garcia ◽

Steven V. Ley

Keyword(s):

Total Synthesis ◽

Antifungal Agents

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An Expedient Total Synthesis of Chivosazole F: an Actin-Binding Antimitotic Macrolide from the Myxobacterium Sorangium Cellulosum

Angewandte Chemie International Edition ◽

10.1002/anie.201610636 ◽

2016 ◽

Vol 56 (2) ◽

pp. 645-649 ◽

Cited By ~ 13

Author(s):

Simon Williams ◽

Jialu Jin ◽

S. B. Jennifer Kan ◽

Mungyuen Li ◽

Lisa J. Gibson ◽

...

Keyword(s):

Total Synthesis ◽

Actin Binding ◽

Sorangium Cellulosum

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ChemInform Abstract: Total Synthesis of (-)-Spirangien A (I), an Antimitotic Polyketide Isolated from the Myxobacterium Sorangium cellulosum.

ChemInform ◽

10.1002/chin.200932202 ◽

2009 ◽

Vol 40 (32) ◽

Author(s):

Ian Paterson ◽

Alison D. Findlay ◽

Christian Noti

Keyword(s):

Total Synthesis ◽

Sorangium Cellulosum

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Metabolites of Lachnellulafuscosanguinea (Rehm). Part 1. The isolation, structure determination, and synthesis of lachnelluloic acid

Canadian Journal of Chemistry ◽

10.1139/v85-197 ◽

1985 ◽

Vol 63 (6) ◽

pp. 1161-1165 ◽

Cited By ~ 14

Author(s):

William A. Ayer ◽

J. Daniel Figueroa Villar

Keyword(s):

Antifungal Activity ◽

Total Synthesis ◽

Causative Agent ◽

Structure Determination ◽

Liquid Culture ◽

Antifungal Agents ◽

Dutch Elm Disease ◽

Spectroscopic Methods

The metabolites produced in liquid culture by the fungus Lachnellulafuscosanguinea (Rehm) Dennis have been examined and two antifungal agents, lachnelluloic acid and lachnellulone, have been isolated. The structure of lachnelluloic acid has been established as (−)-4-hydroxy-3-octanoyl-6-pentyl-5,6-dihydro-2-pyrone (1) by chemical and spectroscopic methods. The total synthesis of racemic lachnelluloic acid, starting from 6,8-tridecanedione (6) is reported. Lachnelluloic acid (1) shows strong antifungal activity against Ceratocystisulmi, the causative agent of Dutch elm disease.

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