Corrigendum: Isolation and Total Synthesis of Icumazoles and Noricumazoles-Antifungal Antibiotics and Cation-Channel Blockers from Sorangium cellulosum

A detailed account on total synthesis, analogue synthesis, biological evaluation and SAR of palmyrolide A macrocycles towards sodium channel inhibition is reported.

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Effects of Mechano-Gated Cation Channel Blockers on Xenopus Oocyte Growth and Development

The Journal of Membrane Biology ◽

10.1007/s002329900430 ◽

1998 ◽

Vol 165 (2) ◽

pp. 161-174 ◽

Cited By ~ 20

Author(s):

N.C. Wilkinson ◽

F. Gao ◽

O.P. Hamill

Keyword(s):

Growth And Development ◽

Xenopus Oocyte ◽

Cation Channel ◽

Channel Blockers ◽

Oocyte Growth

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The Anti-Proliferative Effect of Cation Channel Blockers on T Lymphocytes Stimulated by Anti-CD3 and Anti-CD28

Biophysical Journal ◽

10.1016/j.bpj.2014.11.3199 ◽

2015 ◽

Vol 108 (2) ◽

pp. 586a-587a

Author(s):

Zoltan Varga ◽

Zoltan Petho ◽

Andras Balajthy ◽

Adam Bartok ◽

Sandor Somodi ◽

...

Keyword(s):

T Lymphocytes ◽

Cation Channel ◽

Channel Blockers ◽

Proliferative Effect

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Effect of cations and cation channel blockers on human natural killer cells

International Journal of Immunopharmacology ◽

10.1016/0192-0561(85)90079-7 ◽

1985 ◽

Vol 7 (4) ◽

pp. 573-576 ◽

Cited By ~ 5

Author(s):

T. Huwyler ◽

A. Hirt ◽

D. Felix ◽

A. Morell

Keyword(s):

Natural Killer Cells ◽

Natural Killer ◽

Cation Channel ◽

Channel Blockers ◽

Killer Cells ◽

Human Natural Killer Cells

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Role of phosphoinositide 3-kinase in the nonselective cation channel activation by endothelin-1/endothelinBreceptor

AJP Cell Physiology ◽

10.1152/ajpcell.00384.2002 ◽

2003 ◽

Vol 284 (2) ◽

pp. C506-C510 ◽

Cited By ~ 11

Author(s):

Yoshifumi Kawanabe ◽

Nobuo Hashimoto ◽

Tomoh Masaki

Keyword(s):

Chinese Hamster ◽

Pi3k Pathway ◽

Cation Channel ◽

Channel Blockers ◽

Nonselective Cation Channel ◽

Channel Activation ◽

Endothelin 1 ◽

Ovarian Cells ◽

Phosphoinositide 3 Kinase

We recently demonstrated that endothelin-1 (ET-1) activates two types of Ca2+-permeable nonselective cation channel (designated NSCC-1 and NSCC-2) in Chinese hamster ovarian cells expressing endothelinB receptor (CHO-ETBR). These channels can be discriminated using the Ca2+ channel blockers, LOE 908 and SK&F 96365. LOE 908 is a blocker of NSCC-1 and NSCC-2, whereas SK&F 96365 is a blocker of NSCC-2. In this study, we investigated the possible role of phosphoinositide 3-kinase (PI3K) in the ET-1-induced activation of NSCCs in CHO-ETBR using wortmannin and LY-294002, inhibitors of PI3K. ET-1-induced Ca2+ influx was partially inhibited in CHO-ETBR pretreated with wortmannin or LY-294002. In contrast, addition of wortmannin or LY-294002 after stimulation with ET-1 did not suppress Ca2+ influx. The Ca2+ channels activated by ET-1 in wortmannin- or LY-294002-treated CHO-ETBR were sensitive to LOE 908 and resistant to SK&F 96365. In conclusion, NSCC-2 is stimulated by ET-1 via PI3K-dependent cascade, whereas NSCC-1 is stimulated independently of the PI3K pathway. Moreover, PI3K seems to be required for the initiation of the Ca2+ entry through NSCC-2 but not for its maintenance.

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TRPC5 as a candidate for the nonselective cation channel activated by muscarinic stimulation in murine stomach

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.00069.2002 ◽

2003 ◽

Vol 284 (4) ◽

pp. G604-G616 ◽

Cited By ~ 80

Author(s):

Young Mee Lee ◽

Byung Joo Kim ◽

Hyun Jin Kim ◽

Dong Ki Yang ◽

Mei Hong Zhu ◽

...

Keyword(s):

Transient Receptor Potential ◽

Receptor Potential ◽

Cation Channel ◽

Trp Channel ◽

Channel Blockers ◽

Nonselective Cation Channel ◽

Rt Pcr ◽

Pipette Solution ◽

Gastric Myocytes ◽

Transient Receptor

We investigated which transient receptor potential (TRP) channel is responsible for the nonselective cation channel (NSCC) activated by carbachol (CCh) in murine stomach with RT-PCR and the electrophysiological method. All seven types of TRP mRNA were detected in murine stomach with RT-PCR. When each TRP channel was expressed, the current-voltage relationship of mTRP5 was most similar to that recorded in murine gastric myocytes. mTRP5 showed a conductance order of Cs+ > K+ > Na+, similar to that in the murine stomach. With 0.2 mM GTPγS in the pipette solution, the current was activated transiently in both NSCC in the murine stomach and the expressed mTRP5. Both NSCC activated by CCh in murine stomach and mTRP5 were inhibited by intracellularly applied anti-Gq/11 antibody, PLC inhibitor U-73122, IICR inhibitor 2-aminoethoxydiphenylborate, and nonspecific cation channel blockers La3+ and flufenamate. There were two other unique properties. Both the native NSCC and mTRP5 were activated by 1-oleoyl-2-acetyl-sn-glycerol. Without the activation of NSCC by CCh, the NSCC in murine stomach was constitutively active like mTRP5. From the above results, we suggest that mTRP5 might be a candidate for the NSCC activated by ACh or CCh in murine stomach.

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