scholarly journals Altered Membrane Mechanics Provides a Receptor‐Independent  Pathway for Serotonin Action

2021 ◽  
Author(s):  
Simli Dey ◽  
Dayana Surendran ◽  
Oskar Enberg ◽  
Ankur Gupta ◽  
Sashaina E. Fanibunda ◽  
...  
Keyword(s):  
Membrane Mechanics

scholarly journals Changes in lipid membrane mechanics induced by di- and tri-phenyltins

2017 ◽  
Vol 1859 (8) ◽  
pp. 1301-1309 ◽  
Author(s):  
Magda Przybyło ◽  
Dominik Drabik ◽  
Kamila Szostak ◽  
Tomasz Borowik ◽  
Beate Klösgen ◽  
...  
Keyword(s):  
Lipid Membrane ◽  
Membrane Mechanics

scholarly journals Basement membrane mechanics shape development: Lessons from the fly

2019 ◽  
Vol 75-76 ◽  
pp. 72-81 ◽  
Author(s):  
William Ramos-Lewis ◽  
Andrea Page-McCaw
Keyword(s):  
Basement Membrane ◽  
Membrane Mechanics

“Suction Caps”: Designing Anisotropic Core/Shell Microcapsules with Controlled Membrane Mechanics and Substrate Affinity

2016 ◽  
Vol 26 (34) ◽  
pp. 6224-6237 ◽  
Author(s):  
Huda A. Jerri ◽  
Marlène Jacquemond ◽  
Christopher Hansen ◽  
Lahoussine Ouali ◽  
Philipp Erni
Keyword(s):  
Core Shell ◽  
Substrate Affinity ◽  
Membrane Mechanics

Extracting the Elastic Modulus of Compliant Materials Using a Novel Plate Bulge Testing Technique

2008 ◽  
Author(s):  
S. Golan ◽  
D. Elata ◽  
U. Dinnar
Keyword(s):  
Elastic Modulus ◽  
Plate Theory ◽  
Biological Tissues ◽  
Bulge Test ◽  
The Novel ◽  
Membrane Mechanics ◽  
Testing Technique ◽  
Bulge Testing ◽  
Novel Method

The mechanical properties of compliant materials such as biological tissues and biocompatible soft polymers are essential in medical research and engineering applications. These properties are often determined using techniques that require costly instrumentation (e.g. pull test machines). Alternative and more accessible methods can significantly aid the characterization process. The bulge test determines a material elastic modulus by analyzing the pressure-deflection response of thin samples made of this material. The technique has been extensively employed in the characterization of metals and semiconductors (modulus ∼ 100 GPa). By employing plate rather than membrane mechanics, the present study extends bulge testing to characterize materials with a modulus that is five orders of magnitude lower (∼ 1 MPa). The novel method is demonstrated analytically using plate theory, numerically using finite element modeling and experimentally by successfully applying it to polydimethylsiloxane (modulus ∼ 1.33 MPa). The introduced technique does not require costly equipment, is simple to implement and presents an appealing alternative to current characterization approaches.

Capture, Deformation, Rolling and Detachment of a Cell on an Adhesive Surface in a Shear Flow

2008 ◽  
Author(s):  
Vijay Pappu ◽  
Prosenjit Bagchi
Keyword(s):  
Shear Flow ◽  
Bond Strength ◽  
Three Dimensional ◽  
Navier Stokes ◽  
Adherent Cell ◽  
Membrane Mechanics ◽  
Flow Solver ◽  
Front Tracking Method ◽  
Adhesive Surface ◽  
Computational Modeling And Simulation

Three-dimensional computational modeling and simulation using front tracking method are presented on the motion of a deformable cell over an adhesive surface in a shear flow. The numerical method couples a Navier-Stokes flow solver with cell membrane mechanics, and a Monte Carlo simulation to capture stochastic formation and breakage of receptor/ligand bonds. The entire range of events during cell adhesion, namely, initial arrest of a free-flowing cell, slow rolling of an adherent cell, and detachment off the surface is simulated. Simulations are conducted to signify the role of hydrodynamic lift force that exists for a deformable particle in a wall-bounded flow. Three sets of numerical experiments are presented. In the first set, we consider the initial arrest of the cell, and show that the time needed for the cell to arrest increases with increasing Ca, but rapidly drops and saturates for higher bond strength. In the second set, we consider quasi-steady rolling motion of the cell, and predict the experimentally observed “stop and go” motion of the rolling leukocytes which is characterized by intermittent pauses and sudden jumps in cell velocity. In the third set we consider the detachment of the cell from the surface upon breakage of bonds. The bond strength needed to prevent the detachment of an adherent cell is computed and shown to be maximum for an intermediate Ca.

Sign in / Sign up

Export Citation Format

Share Document