Sodium Butylated Hydroxytoluene: A Functional Group Tolerant, Eco‐Friendly Base for Solvent‐Free, Pd‐Catalysed Amination

2021 ◽  
Author(s):  
Michael G Organ ◽  
Volodymyr Semeniuchenko ◽  
Wilfried M. Braje
Keyword(s):  
Functional Group ◽  
Solvent Free ◽  
Butylated Hydroxytoluene

scholarly journals Homocoupling of terminal alkynes catalyzed by CuCl under solvent-free conditions

2021 ◽  
pp. 174751982110325
Author(s):  
Yan Xiao ◽  
Jiyu Gao ◽  
Peng Chen ◽  
Guangliang Chen ◽  
Zicheng Li ◽  
...  
Keyword(s):  
Functional Group ◽  
Reaction Times ◽  
Environmentally Friendly ◽  
Solvent Free ◽  
Copper Salt ◽  
Terminal Alkynes ◽  
Mild Conditions ◽  
Solvent Free Conditions ◽  
Environmentally Friendly Process

A series of symmetrical 1,4-disubstituted buta-1,3-diynes is prepared with excellent yields (up to 95%) through homocoupling of terminal alkynes catalyzed by a copper salt under solvent-free conditions. This method provides an environmentally friendly process to prepare 1,3-diynes in short reaction times under mild conditions. Furthermore, the method is suitable for a wide substrate scope and has excellent functional group compatibility. The reaction can also be scaled up to gram level.

Efficient CO2 fixation into cyclic carbonates catalyzed by NNO-scorpionate zinc complexes

2019 ◽  
Vol 48 (28) ◽  
pp. 10733-10742 ◽  
Author(s):  
Sonia Sobrino ◽  
Marta Navarro ◽  
Juan Fernández-Baeza ◽  
Luis F. Sánchez-Barba ◽  
Andrés Garcés ◽  
...  
Keyword(s):  
Co2 Fixation ◽  
Functional Group ◽  
Zinc Complexes ◽  
Solvent Free ◽  
Cyclic Carbonates ◽  
Solvent Free Conditions

Chiral bifunctional and bicomponent NNO-scorpionate zinc-based catalysts have been developed for the fixation of CO2 into cyclic carbonates with broad substrate scope and functional group tolerance under mild and solvent-free conditions.

scholarly journals SOLVENT-FREE SYNTHESIS OF AMIDE: A NOVEL TECHNIQUE OF GREEN CHEMISTRY

2021 ◽  
pp. 99-102
Author(s):  
CHIRAGKUMAR J GOHIL ◽  
MALLESHAPPA N NOOLVI
Keyword(s):  
Carboxylic Acid ◽  
Green Chemistry ◽  
Good Yield ◽  
Functional Group ◽  
Environmental Issues ◽  
Solvent Free ◽  
Novel Technique ◽  
Rate Of Reaction ◽  
Solvent Free Synthesis ◽  
Very High

Objective: Amide is one of the most important functional group presents in the chemicals, pharmaceuticals, and foods. Conventionally, it has been synthesized from the carboxylic acid and amines. This conventional reaction is lengthy and involves hazardous chemicals and solvents. Hence, it poses waste management, solvent removal, and environmental issues to the industries. To overcome this limitation, we have reported the green chemistry-based method for the synthesis of amide from carboxylic acid and urea. Methods: In this reaction, we have used boric acid as a catalyst, it is a simple and readily available compound. It is simple, efficient, and solvent-free procedure which involves the trituration of the reactant mixture and subsequent, direct heating of the triturated mixture. Results: The rate of reaction is very high and can synthesize the amide quickly. Conclusion: Various amides were prepared in good yield by this technique.

Metal-free cross-coupling reaction of aldehydes with disulfides by using DTBP as an oxidant under solvent-free conditions

2014 ◽  
Vol 16 (5) ◽  
pp. 2644-2652 ◽  
Author(s):  
Jing-Wen Zeng ◽  
Yi-Chen Liu ◽  
Ping-An Hsieh ◽  
Yu-Ting Huang ◽  
Chih-Lun Yi ◽  
...  
Keyword(s):  
Functional Group ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Solvent Free ◽  
Metal Free ◽  
Cross Coupling Reaction ◽  
Solvent Free Conditions

A DTBP-promoted C–H thiolation of aldehydes with disulfides under metal-free and solvent-free conditions is described. The system shows good functional group tolerance to afford thioesters in moderate to excellent yields.

An Efficient Solvent-Free Synthesis of Bis(2-Tetrahydrobenzofuranyl)Alkanes Catalyzed by H2SO4•SiO2

2014 ◽  
Vol 1033-1034 ◽  
pp. 49-52
Author(s):  
Fan Zhang ◽  
Lu Lu Xiao ◽  
Lei Jin ◽  
Wen Bin Wang ◽  
Nian Yu Huang
Keyword(s):  
Good Yield ◽  
Functional Group ◽  
Condensation Reaction ◽  
Reaction Times ◽  
Solvent Free ◽  
Environmentally Benign ◽  
Simple Operation ◽  
Solvent Free Conditions ◽  
Benign Nature ◽  
Solvent Free Synthesis

A series of bis (2-tetrahydrobenzofuranyl) alkanes in good yield under solvent-free conditions from differently aromatic substituted aldehydes and 3-methyl-6,7-dihydrobenzofuran-4(5H)-one in the presence of H2SO4•SiO2 as catalyst at 90oC. Their structures were characterized by NMR, IR and ESI-MS. The proposed mechanism for the H2SO4•SiO2-catalyzed condensation reaction have been discussed in the work. This versatile approach has the advantages of broad functional group compatibility, short reaction times, simple operation and environmentally benign nature.

Solvent-free N-iodosuccinimide-promoted synthesis of spiroimidazolines from alkenes and amidines under ball-milling conditions

2018 ◽  
Vol 5 (19) ◽  
pp. 2864-2869 ◽  
Author(s):  
Hui Xu ◽  
Kuan Chen ◽  
Hong-Wei Liu ◽  
Guan-Wu Wang
Keyword(s):  
Ball Milling ◽  
Functional Group ◽  
Solvent Free ◽  
Environmentally Benign ◽  
Intermolecular Cyclization

An environmentally benign and N-iodosuccinimide-promoted intermolecular cyclization between alkenes and amidines has been demonstrated under solvent-free ball-milling conditions, affording a variety of spiroimidazolines with remarkable functional group tolerance and good to excellent yields.

A Practical Approach for the Transamidation of N,N-Dimethyl Amides with Primary Amines Promoted by Sodium tert-Butoxide under Solvent-Free Conditions

Synthesis ◽  
2020 ◽  
Vol 52 (21) ◽  
pp. 3286-3294
Author(s):  
Hua Cheng ◽  
Cheng Chen ◽  
Rui Zhang ◽  
Jun-Chao Zhang ◽  
Wei-Yi Zhang ◽  
...  
Keyword(s):  
Room Temperature ◽  
Functional Group ◽  
Solvent Free ◽  
Primary Amines ◽  
Practical Applications ◽  
Alkyl Groups ◽  
Solvent Free Conditions ◽  
Plausible Mechanism ◽  
High Yields ◽  
Work Up

AbstractA practical sodium tert-butoxide (NaOtBu)-mediated protocol is disclosed for the transamidation of various N,N-dimethyl amides with primary amines to afford the corresponding amides in moderate to good yields at room temperature under solvent-free conditions. This protocol features a facile work-up procedure and good functional group compatibility, especially for N,N-dimethyl amides with long-chain alkyl groups and heteroatom-containing amines. Notably, a few representative gram-scale reactions proceed smoothly to furnish the desired amides in high yields, which demonstrates the potential of this process for further practical applications. Several control experiments are carried out and a plausible mechanism is provided.

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