A Radical Addition/Cyclization and Se‐group Transfer Strategy for the Facile Synthesis of Se‐containing Cyclopentenes under Metal‐Free and Peroxide‐Free Conditions

2021 ◽  
Author(s):  
Dian-Liang Wang ◽  
Nan-Quan Jiang ◽  
Zhong-Jian Cai ◽  
Shun-Jun Ji
Keyword(s):  
Radical Addition ◽  
Facile Synthesis ◽  
Group Transfer ◽  
Metal Free

Catalytic, metal-free sulfonylcyanation of alkenes via visible light organophotoredox catalysis

2018 ◽  
Vol 54 (25) ◽  
pp. 3162-3165 ◽  
Author(s):  
Jianfeng Sun ◽  
Peng Li ◽  
Lei Guo ◽  
Fang Yu ◽  
Yu-Peng He ◽  
...  
Keyword(s):  
Visible Light ◽  
Radical Addition ◽  
Neutral Group ◽  
Group Transfer ◽  
Metal Free ◽  
Catalytic Metal

A catalytic, redox-neutral group transfer radical addition of olefins with tosyl cyanide via visible light-induced organophotoredox catalysis has been described.

Synthesis of Pyrrolo[1,2-a][1,6]- and [1,8]naphthyridines by Alkyne-Carbonyl Metathesis

Synthesis ◽  
2020 ◽  
Author(s):  
Peter Ehlers ◽  
Peter Langer ◽  
Marian Blanco Ponce ◽  
Silvio Parpart ◽  
Alexander Villinger ◽  
...  
Keyword(s):  
Heterocyclic Compounds ◽  
Metathesis Reaction ◽  
Synthetic Methodology ◽  
Facile Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
Metal Free ◽  
Modular Synthesis

AbstractA concise and modular synthesis of pyrrolo[1,2-a][1,6]- and [1,8]naphthyridines by a one-pot two-step reaction consisting of electrophilic acylation followed by an alkyne-carbonyl-metathesis reaction as the final cyclization step is reported. This developed synthetic methodology allows the facile synthesis of these heterocyclic core structures in mainly high overall yields under metal-free conditions. Reaction conditions are carefully optimized and display a novel supplement to access these tricyclic heterocyclic compounds.

Transition-metal-free and facile synthesis of 3-alkynylpyrrole-2, 4-dicarboxylates from methylene isocyanides and propiolaldehyde

2021 ◽  
Author(s):  
Xiaoli Huo ◽  
Xiaojuan Chen ◽  
Liya Yu ◽  
Chong Zhang ◽  
Linghui Zeng ◽  
...  
Keyword(s):  
Transition Metal ◽  
Efficient Method ◽  
Transformation Process ◽  
Facile Synthesis ◽  
Direct Transformation ◽  
Metal Free

A transition-metal-free, facile and efficient method for the synthesis of 3-alkynylpyrrole-2, 4-dicarboxylates from methylene isocyanides and propiolaldehyde with moderate to good yields has been developed. The direct transformation process and...

Visible light driven metal-free intramolecular cyclization: a facile synthesis of 3-position substituted 3,4-dihydroisoquinolin-1(2H)-one

2019 ◽  
Vol 17 (2) ◽  
pp. 380-387 ◽  
Author(s):  
Shuai Zou ◽  
Shu Geng ◽  
Lina Chen ◽  
Haitao Wang ◽  
Feng Huang
Keyword(s):  
Visible Light ◽  
Intramolecular Cyclization ◽  
Facile Synthesis ◽  
Metal Free ◽  
Visible Light Driven

Visible light driven metal-free intramolecular cyclization: a facile synthesis of 3-position substituted 3,4-dihydroisoquinolin-1(2H)-one.

A novel and facile synthesis of 4-arylquinolin-2(1H)-ones under metal-free conditions

2015 ◽  
Vol 26 (8) ◽  
pp. 977-979 ◽  
Author(s):  
Bin Sun ◽  
Wen-Peng Mai ◽  
Liang-Ru Yang ◽  
Pu Mao ◽  
Jin-Wei Yuan ◽  
...  
Keyword(s):  
Facile Synthesis ◽  
Metal Free

K2S2O8-mediated metal-free direct P–H/C–H functionalization: a convenient route to benzo[b]phosphole oxides from unactivated alkynes

2016 ◽  
Vol 18 (12) ◽  
pp. 3522-3526 ◽  
Author(s):  
Dumei Ma ◽  
Weizhu Chen ◽  
Gaobo Hu ◽  
Yun Zhang ◽  
Yuxing Gao ◽  
...  
Keyword(s):  
Heavy Metal ◽  
Metal Contamination ◽  
Heavy Metal Contamination ◽  
Radical Addition ◽  
Metal Free ◽  
Internal Alkynes ◽  
Convenient Route

A metal-free and K2S2O8-mediated radical addition/cyclization of internal alkynes leading to benzo[b]phosphole oxides was developed, which eliminates residual heavy metal contamination in the product.

N-Chloroamines as substrates for metal-free photochemical atom-transfer radical addition reactions in continuous flow

2021 ◽  
Author(s):  
Alexander Steiner ◽  
Oscar de Frutos ◽  
Juan A. Rincón ◽  
Carlos Mateos ◽  
Jason Williams ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Radical Addition ◽  
Addition Reactions ◽  
Atom Transfer ◽  
Metal Free ◽  
Atom Transfer Radical Addition

N-Chloroamines have recently seen interest as substrates for atom-transfer radical addition (ATRA) reactions with olefins, to form β-chloroamine products, with complete atom incorporation. We report the development of a fully...

A metal‐free visible light promoted three‐component facile synthesis of 4‐oxo‐tetrahydroindoles in ethanol–water

2020 ◽  
Author(s):  
Khursheed Ansari ◽  
Mohd Nazeef ◽  
Shabir Ali ◽  
Malik A. Waseem ◽  
Wajaht A. Shah ◽  
...  
Keyword(s):  
Visible Light ◽  
Facile Synthesis ◽  
Metal Free

Transition metal-free, visible-light-mediated construction of α,β-diamino esters via decarboxylative radical addition at room temperature

2019 ◽  
Vol 6 (13) ◽  
pp. 2245-2249 ◽  
Author(s):  
Guibing Wu ◽  
Jingwen Wang ◽  
Chengyu Liu ◽  
Maolin Sun ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Transition Metal ◽  
Visible Light ◽  
Carboxylic Acids ◽  
Room Temperature ◽  
Radical Addition ◽  
Metal Free ◽  
Radical Coupling

A metal-free photoredox catalyzed decarboxylative radical coupling of free-carboxylic acids and glyoxylic oximes was developed to synthesize α,β-diamino acids.

Photoinduced Oxidative Cross-Coupling for O–S Bond Formation: A Facile Synthesis of Alkyl Benzenesulfonates

Synlett ◽  
2017 ◽  
Vol 28 (13) ◽  
pp. 1558-1563 ◽  
Author(s):  
Aiwen Lei ◽  
Atul Singh ◽  
Hong Yi ◽  
Guoting Zhang ◽  
Changliang Bian ◽  
...  
Keyword(s):  
Visible Light ◽  
Bond Formation ◽  
Cross Coupling ◽  
Selective Synthesis ◽  
Mechanistic Studies ◽  
Facile Synthesis ◽  
Metal Free

We have developed a photoinduced oxidative cross-coupling of thiophenols with alcohols for O–S bond formation. The protocol uses visible light, a metal-free photocatalyst, and oxygen as the oxidant for the selective synthesis of alkyl benzenesulfonates; no ligand co-additive is necessary. Mechanistic studies suggested that the disulfide and alkyl benzenesulfinate are involved as intermediates and that the transformation proceeds by a radical pathway.

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