ChemInform Abstract: A FACILE CONVERSION OF CARBOXYLIC ACIDS TO CARBINOLS UNDER MILD CONDITIONS

We have developed I2/KH2PO2 and KI/P(OEt)3 strategy syntheses of esters from carboxylic acids and alcohols through different reaction mechanisms. The advantages of present protocol: mild conditions and late-stage diversification of natural products.

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ChemInform Abstract: Nucleophilic Acyl Substitution via Aromatic Cation Activation of Carboxylic Acids: Rapid Generation of Acid Chlorides under Mild Conditions.

ChemInform ◽

10.1002/chin.201032057 ◽

2010 ◽

Vol 41 (32) ◽

pp. no-no

Author(s):

David J. Hardee ◽

Lyudmila Kovalchuke ◽

Tristan H. Lambert

Keyword(s):

Carboxylic Acids ◽

Acid Chlorides ◽

Mild Conditions ◽

Cation Activation ◽

Rapid Generation ◽

Nucleophilic Acyl Substitution

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Convenient Preparation of Primary Amides via Activation of Carboxylic Acids with Ethyl Chloroformate and Triethylamine under Mild Conditions

Chemistry Letters ◽

10.1246/cl.130096 ◽

2013 ◽

Vol 42 (6) ◽

pp. 580-582 ◽

Cited By ~ 9

Author(s):

Takuya Noguchi ◽

Masahiro Sekine ◽

Yuki Yokoo ◽

Seunghee Jung ◽

Nobuyuki Imai

Keyword(s):

Carboxylic Acids ◽

Ethyl Chloroformate ◽

Mild Conditions ◽

Convenient Preparation

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Decarboxylative sulfenylation of amino acids via metallaphotoredox catalysis

Organic Chemistry Frontiers ◽

10.1039/c9qo00817a ◽

2019 ◽

Vol 6 (18) ◽

pp. 3224-3227 ◽

Cited By ~ 11

Author(s):

Lidan Wei ◽

Chengjuan Wu ◽

Chen-Ho Tung ◽

Wenguang Wang ◽

Zhenghu Xu

Keyword(s):

Amino Acids ◽

Visible Light ◽

Carboxylic Acids ◽

Mild Conditions ◽

Cooperative Catalysis

A nickel/visible light photoredox co-catalyzed decarboxylative thiolation reaction of carboxylic acids has been developed. This odorless sulfenylation reaction proceeded well via a nickel/photoredox cooperative catalysis pathway under very mild conditions.

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ChemInform Abstract: Tandem Decarboxylative Hydroformylation-Hydrogenation Reaction of α,β-Unsaturated Carboxylic Acids Toward Aliphatic Alcohols under Mild Conditions Employing a Supramolecular Catalyst System.

ChemInform ◽

10.1002/chin.201407042 ◽

2014 ◽

Vol 45 (7) ◽

pp. no-no

Author(s):

Lisa Diab ◽

Urs Gellrich ◽

Bernhard Breit

Keyword(s):

Carboxylic Acids ◽

Catalyst System ◽

Hydrogenation Reaction ◽

Aliphatic Alcohols ◽

Mild Conditions ◽

Unsaturated Carboxylic Acids

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Enzyme cascade reactions: synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem

Green Chemistry ◽

10.1039/c5gc00707k ◽

2015 ◽

Vol 17 (6) ◽

pp. 3271-3275 ◽

Cited By ~ 73

Author(s):

Shane M. McKenna ◽

Silke Leimkühler ◽

Susanne Herter ◽

Nicholas J. Turner ◽

Andrew J. Carnell

Keyword(s):

Carboxylic Acids ◽

Cascade Reactions ◽

Preparative Scale ◽

Mild Conditions ◽

Enzyme Cascade ◽

Furandicarboxylic Acid

Three enzymes are combined under mild conditions for the preparative scale oxidation of HMF to FDCA and a range of 10 alcohols.

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Synthesis of O-Aroyl-N,N-dimethylhydroxylamines through Hypervalent Iodine-Mediated Amination of Carboxylic Acids with N,N-Dimethylformamide

Synthesis ◽

10.1055/s-0036-1588460 ◽

2017 ◽

Vol 49 (18) ◽

pp. 4303-4308 ◽

Cited By ~ 3

Author(s):

Dong Li ◽

Chuancheng Zhang ◽

Qiang Yue ◽

Zhen Xiao ◽

Xianglan Wang ◽

...

Keyword(s):

Carboxylic Acids ◽

Room Temperature ◽

Functional Group ◽

Hypervalent Iodine ◽

Electrophilic Amination ◽

Mild Conditions

An efficient protocol for the synthesis of O-aroyl-N,N-dimethylhydroxylamines, which are important electrophilic amination reagents, is described. The reaction between carboxylic acids and N,N-dimethylformamide is mediated by hypervalent iodine and occurs under mild conditions at room temperature to give the desired products in good yields. The process shows good functional group compatibility and air and moisture tolerance.

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Use of Ethyl (Benzothiazol-2-ylsulfonyl)acetate for Malonic Ester-type Syntheses of Carboxylic Acids and Esters

Australian Journal of Chemistry ◽

10.1071/ch14085 ◽

2014 ◽

Vol 67 (9) ◽

pp. 1222 ◽

Cited By ~ 2

Author(s):

Waleed M. Hussein ◽

Ross P. McGeary

Keyword(s):

Carboxylic Acids ◽

Alkyl Halides ◽

Malonic Ester ◽

One Pot ◽

Dichloromethane Solution ◽

Mild Conditions ◽

Acetic Acids

A new methodology for the synthesis of substituted carboxylic acids is described. Alkylation of either ethyl (benzothiazol-2-ylsulfonyl)acetate or ethyl 2-(benzothiazol-2-ylsulfonyl)propionate was achieved with alkyl halides and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in dichloromethane solution. These products were then desulfinated and hydrolysed in one-pot under mild conditions to give substituted acetic acids in good-to-excellent yields.

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