scholarly journals Mechanically induced solvent-free esterification method at room temperature

RSC Advances ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 5080-5085
Author(s):  
Lei Zheng ◽  
Chen Sun ◽  
Wenhao Xu ◽  
Alexandr V. Dushkin ◽  
Nikolay Polyakov ◽  
...  
Keyword(s):  
Natural Products ◽  
Carboxylic Acids ◽  
Late Stage ◽  
Reaction Mechanisms ◽  
Room Temperature ◽  
Solvent Free ◽  
Mild Conditions

We have developed I2/KH2PO2 and KI/P(OEt)3 strategy syntheses of esters from carboxylic acids and alcohols through different reaction mechanisms. The advantages of present protocol: mild conditions and late-stage diversification of natural products.

A multicomponent reaction on a ‘free’ KCC-1 catalyst at room temperature under solvent free conditions by visible light

RSC Advances ◽  
2016 ◽  
Vol 6 (59) ◽  
pp. 54236-54240 ◽  
Author(s):  
Seyed Mohsen Sadeghzadeh
Keyword(s):  
Visible Light ◽  
Multicomponent Reaction ◽  
Efficient Method ◽  
Room Temperature ◽  
Solvent Free ◽  
Green Protocol ◽  
Mild Conditions ◽  
Solvent Free Conditions

A green and efficient method for the synthesis of various triazolo[1,2-a]indazoletrione under mild conditions is reported, that making it a genuinely green protocol.

Synthesis of O-Aroyl-N,N-dimethylhydroxylamines through Hypervalent Iodine-Mediated Amination of Carboxylic Acids with N,N-Dimethylformamide

Synthesis ◽  
2017 ◽  
Vol 49 (18) ◽  
pp. 4303-4308 ◽  
Author(s):  
Dong Li ◽  
Chuancheng Zhang ◽  
Qiang Yue ◽  
Zhen Xiao ◽  
Xianglan Wang ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Room Temperature ◽  
Functional Group ◽  
Hypervalent Iodine ◽  
Electrophilic Amination ◽  
Mild Conditions

An efficient protocol for the synthesis of O-aroyl-N,N-dimethylhydroxylamines, which are important electrophilic amination reagents, is described. The reaction between carboxylic acids and N,N-dimethylformamide is mediated by hypervalent iodine and occurs under mild conditions at room temperature to give the desired products in good yields. The process shows good functional group compatibility and air and moisture tolerance.

Construction of a bifunctional Zn(ii)–organic framework containing a basic amine functionality for selective capture and room temperature fixation of CO2

2020 ◽  
Vol 7 (1) ◽  
pp. 72-81 ◽  
Author(s):  
Rajesh Das ◽  
Sandeep Singh Dhankhar ◽  
C. M. Nagaraja
Keyword(s):  
Room Temperature ◽  
Solvent Free ◽  
Cyclic Carbonates ◽  
Mild Conditions ◽  
Basic Amine ◽  
Organic Framework

The construction of a novel 3D, porous, bifunctional Zn(ii)–organic framework featuring two-types of 1D channels for efficient fixation of CO2 to cyclic carbonates under solvent-free mild conditions of RT is reported.

Imidazole-induced self-assembly of polyoxovanadate cluster organic framework for efficient Knoevenagel condensation under mild conditions

CrystEngComm ◽  
2020 ◽  
Vol 22 (24) ◽  
pp. 4147-4153 ◽  
Author(s):  
Ming-Yu Dou ◽  
Dan-Dan Zhong ◽  
Xian-Qiang Huang ◽  
Guo-Yu Yang
Keyword(s):  
Catalytic Activity ◽  
Self Assembly ◽  
Room Temperature ◽  
Knoevenagel Condensation ◽  
Solvent Free ◽  
Mild Conditions ◽  
Highly Efficient ◽  
Organic Framework

Three new polyoxovanadates have been made, one of them displays highly efficient heterogeneous solvent-free catalytic activity and excellent recyclability in the Knoevenagel condensation at room temperature.

One-pot, solvent-free synthesis of α-aminonitriles under catalysis by magnesium bromide ethyl etherate

2006 ◽  
Vol 84 (3) ◽  
pp. 429-432 ◽  
Author(s):  
Mohammad M Mojtahedi ◽  
M Saeed Abaee ◽  
Hassan Abbasi
Keyword(s):  
Room Temperature ◽  
Catalytic Amount ◽  
Solvent Free ◽  
Magnesium Bromide ◽  
One Pot ◽  
Trimethylsilyl Cyanide ◽  
Mild Conditions ◽  
Rapid Formation ◽  
Solvent Free Synthesis

A three-component, efficient, and facile procedure has been developed for the synthesis of α-aminonitriles from aldehydes, amines, and trimethylsilyl cyanide using a catalytic amount of magnesium bromide ethyl etherate in the absence of solvent. Rapid formation of products is observed at room temperature in a one-pot procedure under very mild conditions giving excellent yields of the title compounds.Key words: catalyzed Strecker's reaction, α-aminonitriles, magnesium bromide, solvent-free.

Access to Highly Substituted Pyrimidine N-Oxides and 4-Acetoxymethyl-Substituted Pyrimidines via the LANCA Three-Component Reaction–Cyclocondensation Sequence

Synthesis ◽  
2021 ◽  
Author(s):  
Reinhold Zimmer ◽  
Hans-Ulrich Reissig ◽  
Luise Schefzig ◽  
Timon Kurzawa ◽  
Giaime Rancan ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Room Temperature ◽  
Hydroxylamine Hydrochloride ◽  
Trifluoroacetic Anhydride ◽  
Pyrimidine Derivatives ◽  
Mild Conditions ◽  
Structural Variety ◽  
Three Component Reaction ◽  
Sterically Demanding ◽  
Synthetic Utility

AbstractThe LANCA three-component reaction of lithiated alkoxy­allenes (LA), nitriles (N), and carboxylic acids (CA) smoothly provides β-alkoxy-β-ketoenamides in broad structural variety. The subsequent cyclocondensation of these compounds with hydroxylamine hydrochloride afforded a large library of pyrimidine N-oxides under mild conditions and in good yields. Their synthetic utility was further increased by the Boekelheide rearrangement leading to 4-acetoxymethyl-substituted pyrimidines. With trifluoroacetic anhydride the rearrangement proceeds even at room temperature and directly furnishes 4-hydroxymethyl-substituted pyrimidine derivatives. The key reactions are very robust and work well even in the presence of sterically demanding substituents.

scholarly journals Selective Esterification of Nonconjugated Carboxylic Acids in the Presence of Conjugated or Aromatic Carboxylic Acids under Mild Conditions

1999 ◽  
Vol 23 (6) ◽  
pp. 378-379
Author(s):  
Ramesh C. Anand ◽  
Vimal ◽  
Archana Milhotra
Keyword(s):  
Carboxylic Acids ◽  
Room Temperature ◽  
Aromatic Carboxylic Acids ◽  
Selective Esterification ◽  
Amberlyst 15 ◽  
Mild Conditions

Nonconjugated carboxylic acids are selectively esterified in good yields in the presence of conjugated or aromatic carboxylic acids by stirring over Amberlyst-15 in alcohol at room temperature.

A [bmim]Cl-promoted domino protocol using an isocyanide-based [4+1]-cycloaddition reaction for the synthesis of diversely functionalized 3-alkylamino-2-alkyl/aryl/hetero-aryl indolizine-1-carbonitriles under solvent-free conditions

2020 ◽  
Vol 44 (8) ◽  
pp. 3241-3248 ◽  
Author(s):  
Amol Balu Atar ◽  
Jongmin Kang ◽  
Arvind H. Jadhav
Keyword(s):  
Ionic Liquid ◽  
Room Temperature ◽  
Cycloaddition Reaction ◽  
Solvent Free ◽  
Alkyl Aryl ◽  
Mild Conditions ◽  
Solvent Free Conditions ◽  
Coupling Strategy ◽  
Multicomponent Coupling

A room temperature-based ionic liquid [bmim]Cl-catalyzed multicomponent coupling strategy for the synthesis of 3-alkylamino-2-alkyl/aryl/hetero-aryl indolizine-1-carbonitrile derivatives under mild conditions is shown.

Efficient green synthesis of monomethine cyanines via grinding under solvent-free conditions

2016 ◽  
Vol 5 (3) ◽  
Author(s):  
Fayez M. Eissa ◽  
Reda S. Abdel Hameed
Keyword(s):  
Room Temperature ◽  
Reaction Times ◽  
Solvent Free ◽  
Synthetic Method ◽  
Mild Conditions ◽  
Green Approach ◽  
Solvent Free Conditions ◽  
Reported Data ◽  
Layer Chromatography ◽  
Inexpensive Procedure

AbstractA solvent-free, efficient, and green approach for the synthesis of monomethine cyanine dyes was carried out via grinding at room temperature in the presence of a minimum amount of catalyst. This green methodology aims to overcome the limitations and drawbacks of previously reported methods such as heating at high temperatures, use of large amounts of catalysts, use of solvents, modest yields, and long reaction times. Moreover, the advantages of the process include mild conditions with excellent conversion, and inexpensive procedure. The new synthetic method was demonstrated for eight reported dyes, as representatives, and showed high applicability for their analogues in the same way. The green context of the new methodology was noticeable, compared with the non-green components of the conventional one. The structure and purity of the resulting compounds were compared with the previously reported data and confirmed using thin layer chromatography, absorption spectra, elemental analysis, mass spectrometry,

Construction of Esters through Sulfuryl Fluoride (SO2F2) Mediated Dehydrative Coupling of Carboxylic Acids with Alcohols at Room Temperature

Synthesis ◽  
2019 ◽  
Vol 51 (20) ◽  
pp. 3901-3907 ◽  
Author(s):  
Shi-Meng Wang ◽  
Njud S. Alharbi ◽  
Hua-Li Qin
Keyword(s):  
Carboxylic Acids ◽  
Room Temperature ◽  
Functional Group ◽  
High Efficiency ◽  
Sulfuryl Fluoride ◽  
Mild Conditions ◽  
High Yields

A facile method for the construction of esters through dehydrative coupling of carboxylic acids with alcohols is developed. The reactions are mediated by sulfuryl fluoride (SO2F2) at room temperature and proceed with high efficiency. The method has several advantages including broad substrate scope, mild conditions, excellent functional group compatibility and affords high yields, even on gram scale.

Sign in / Sign up

Export Citation Format

Share Document