ChemInform Abstract: NEW SYNTHETIC METHODS. INTRAMOLECULAR (4+2)- AND (3+2)-CYCLOADDITIONS IN ORGANIC SYNTHESIS

1977 ◽  
Vol 8 (13) ◽  
pp. no-no
Author(s):  
W. OPPOLZER
Keyword(s):  
Organic Synthesis ◽  
Synthetic Methods

Sēra dioksīda fizikāli ķīmisko īpašību pielietojums jaunu organiskās sintēzes metožu izstrādē / Development of New Organic Synthesis Methods Based on Physico-Chemical Properties of Sulfur Dioxide

2021 ◽  
Author(s):  
◽  
Krista Gulbe
Keyword(s):  
Organic Synthesis ◽  
Chemical Properties ◽  
Coupling Reaction ◽  
Synthetic Methods ◽  
Synthesis Methods ◽  
Chemical Transformations ◽  
Scientific Publications ◽  
Cross Coupling Reaction ◽  
Aryl Acetylenes ◽  
The Republic

The Doctoral Thesis has been prepared as a collection of thematically related scientific publications comprising five publications in the SCI journals, one patent of the Republic of Latvia, and one application for patent of the Republic of Latvia. We have carried out fundamental research on the applications of SO2 as a solvent and reagent in organic synthesis. We have developed several novel synthetic methods that represent the use of liquid SO2 as a solvent for chemical transformations that proceed via carbenium ion intermediates: a) hydration of aryl acetylenes; b) hydrohalogenation of aryl acetylenes; c) ring opening of methylenecyclopropanes with halides; d) glycosylation with glycosyl fluorides. By employing DABSO as an SO2 surrogate, we have also discovered the catalytic activity of Ru(II) complexes towards sulfonylative cross coupling reaction. This finding has been applied for the synthesis of sulfonyl derived compounds.

scholarly journals Revisiting the Structure and Chemistry of 3(5)-Substituted Pyrazoles

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 42 ◽  
Author(s):  
Alina Secrieru ◽  
Paul Michael O’Neill ◽  
Maria Lurdes Santos Cristiano
Keyword(s):  
Organic Synthesis ◽  
Medicinal Chemistry ◽  
Positive Impact ◽  
Biological Activities ◽  
Experimental Methods ◽  
Synthetic Methods ◽  
Conformational Preferences ◽  
Substituted Pyrazoles ◽  
Present Subject

Pyrazoles are known as versatile scaffolds in organic synthesis and medicinal chemistry, often used as starting materials for the preparation of more complex heterocyclic systems with relevance in the pharmaceutical field. Pyrazoles are also interesting compounds from a structural viewpoint, mainly because they exhibit tautomerism. This phenomenon may influence their reactivity, with possible impact on the synthetic strategies where pyrazoles take part, as well as on the biological activities of targets bearing a pyrazole moiety, since a change in structure translates into changes in properties. Investigations of the structure of pyrazoles that unravel the tautomeric and conformational preferences are therefore of upmost relevance. 3(5)-Aminopyrazoles are largely explored as precursors in the synthesis of condensed heterocyclic systems, namely pyrazolo[1,5-a]pyrimidines. However, the information available in the literature concerning the structure and chemistry of 3(5)-aminopyrazoles is scarce and disperse. We provide a revision of data on the present subject, based on investigations using theoretical and experimental methods, together with the applications of the compounds in synthesis. It is expected that the combined information will contribute to a deeper understanding of structure/reactivity relationships in this class of heterocycles, with a positive impact in the design of synthetic methods, where they take part.

Synthetic Methods for the Generation and Preparative Application of Benzyne

2010 ◽  
Vol 63 (7) ◽  
pp. 987 ◽  
Author(s):  
Tsugio Kitamura
Keyword(s):  
Organic Synthesis ◽  
Recent Progress ◽  
Synthetic Methods ◽  
Fluoride Ion ◽  
Mild Conditions ◽  
Frequent Use

Many methods have been developed for generating benzyne. Convenient and reliable precursors extensively studied so far involve benzenediazonium-2-carboxylate and o-dihalobenzenes such as 1,2-bromofluorobenzene and 1,2-dibromobenzene. Recently, in addition to the above precursors, o-(trimethylsilyl)phenyl triflate has been put into frequent use for benzyne reactions, in which benzyne is efficiently generated under mild conditions using fluoride ion. Furthermore, o-(trimethylsilyl)phenyliodonium triflate has been developed as a more efficient benzyne precursor. This mini-review focusses on recent progress in benzyne chemistry from the viewpoint of organic synthesis. The methods for generating benzynes are classified by the conditions into four categories: basic conditions using strong bases, mild conditions using fluoride ion, thermolysis, and oxidation.

scholarly journals Intrinsically Elastic Organic Semiconductors (IEOSs)

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6130
Author(s):  
Fei Liu ◽  
Xueling Hou ◽  
Ben-Lin Hu ◽  
Run-Wei Li
Keyword(s):  
Organic Synthesis ◽  
Organic Semiconductors ◽  
Structural Engineering ◽  
Electronic Devices ◽  
Synthetic Methods ◽  
Chemical Structures ◽  
Mechanical And Electrical Properties ◽  
Wearable Electronic ◽  
Synthetic Routes ◽  
Wearable Electronic Devices

Elastic semiconductors are becoming more and more important to the development of flexible wearable electronic devices, which can be prepared by structural engineering design, blending, and the intrinsic elastification of organic semiconductors (intrinsically elastic organic semiconductor, IEOS). Compared with the elastic semiconductors prepared by structural engineering and blending, the IEOS prepared by organic synthesis has attracted numerous attentions for its solution processability and highly tunable chemical structures. For IEOSs, reasonable designs of synthetic routes and methods are the basis for realizing good mechanical and electrical properties. This brief review begins with a concise introduction of elastic semiconductors, then follows with several synthetic methods of IEOSs, and concludes the characteristics of each method, which provides guidance for the synthesis of IEOSs in the future. Furthermore, the properties of IEOSs are involved from the aspects of electrical, mechanical properties, and the applications of the IEOSs in elastic electronic devices. Finally, the challenge and an outlook which IEOSs are facing are presented in conclusion.

Sign in / Sign up

Export Citation Format

Share Document