ChemInform Abstract: POTENTIAL ANTITUMOR AGENTS: SYNTHESIS AND BIOLOGICAL PROPERTIES OF ALIPHATIC AMINO ACID 9-HYDROXYELLIPTICINIUM DERIVATIVES

1985 ◽  
Vol 16 (6) ◽  
Author(s):  
C. AUCLAIR ◽  
E. VOISIN ◽  
H. BANOUN ◽  
C. PAOLETTI ◽  
J. BERNADOU ◽  
...  
Keyword(s):  
Amino Acid ◽  
Antitumor Agents ◽  
Biological Properties ◽  
Aliphatic Amino Acid ◽  
Potential Antitumor

Potential antitumor agents: synthesis and biological properties of aliphatic amino acid 9-hydroxyellipticinium derivatives

1984 ◽  
Vol 27 (9) ◽  
pp. 1161-1166 ◽  
Author(s):  
Christian Auclair ◽  
Emmanuelle Voisin ◽  
Helene Banoun ◽  
Claude Paoletti ◽  
Jean Bernadou ◽  
...  
Keyword(s):  
Amino Acid ◽  
Antitumor Agents ◽  
Biological Properties ◽  
Aliphatic Amino Acid ◽  
Potential Antitumor

Design, Synthesis of Novel Quinazolone Alkaloids Derivatives as Potential Antitumor Agents

2011 ◽  
Vol 7 (4) ◽  
pp. 295-300
Author(s):  
Youguang Zheng ◽  
Min Sun ◽  
Yi Liu ◽  
Mingdong Li ◽  
Min Ji
Keyword(s):  
Antitumor Agents ◽  
Design Synthesis ◽  
Potential Antitumor

Synthesis and Biological Evaluation of Diaryl Ether Linked DC-81 Conjugates as Potential Antitumor Agents

2013 ◽  
Vol 13 (10) ◽  
pp. 1590-1600 ◽  
Author(s):  
Ahmed Kamal ◽  
A. Viswanath ◽  
M. Ramaiah ◽  
J. Murty ◽  
Farheen Sultana ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Biological Evaluation ◽  
Diaryl Ether ◽  
Synthesis And Biological Evaluation ◽  
Potential Antitumor

Synthesis and Evaluation of A New Series of Thiazole Derivatives as Potential Antitumor Agents and MMP Inhibitors

2017 ◽  
Vol 17 (5) ◽  
pp. 674-681 ◽  
Author(s):  
Zafer Asim Kaplancikli ◽  
Mehlika Dilek Altıntop ◽  
Ozlem Atli ◽  
Belgin Sever ◽  
Merve Baysal ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Thiazole Derivatives ◽  
Mmp Inhibitors ◽  
Potential Antitumor

Vasopressin analogues with effect on central nervous system: Synthesis and biological properties

1983 ◽  
Vol 48 (10) ◽  
pp. 2862-2873 ◽  
Author(s):  
František Brtník ◽  
Ivan Krejčí ◽  
Běla Kupková ◽  
Pavel Hrbas ◽  
Jana Škopková ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Amino Acid ◽  
Passive Avoidance ◽  
Biological Properties ◽  
Passive Avoidance Test ◽  
System Synthesis ◽  
Avoidance Test ◽  
Vasopressin Analogues

Synthesis of four vasopressin analogues which do not contain the glycinamine residue in position 9 and have a basic non-coded amino acid in position 8 is described. All the analogues exhibit very low endocrine activities and are effective in the passive avoidance test.

Biological Function and Chemistry of Endothelin. A Review

1999 ◽  
Vol 64 (8) ◽  
pp. 1211-1252 ◽  
Author(s):  
Jan Hlaváček ◽  
Renáta Marcová
Keyword(s):  
Biological Activity ◽  
Amino Acid ◽  
Biological Function ◽  
Biological Properties ◽  
Structural Basis ◽  
Amino Acid Residues ◽  
Snake Venoms ◽  
Vasoactive Peptides ◽  
Physico Chemical ◽  
Endothelin A

The first part of this review deals with the biosynthesis and a biological function of strongly vasoactive peptides named endothelins (ETs) including vasoactive intestinal contractor. Where it was useful, snake venoms sarafotoxins which are structural endothelin derivatives, were also mentioned. In the second part, an attention is paid to structural basis of the ETs biological activity, with respect to alterations of amino acid residues in the parent peptides modifying the conformation and consequently the physico-chemical and biological properties in corresponding ETs analogs. Special attention is focussed on the area of ETs receptors and their interaction with peptide and non peptide agonists and antagonists, important in designing selective inhibitors of ETs receptors potentially applicable as drugs in a medicine. A review with 182 references.

Diosgenin Derivatives as Potential Antitumor Agents: Synthesis, Cytotoxicity, and Mechanism of Action

2020 ◽  
Author(s):  
Hong Yin ◽  
Min-Jie Zhang ◽  
Ren-Feng An ◽  
Jing Zhou ◽  
Wei Liu ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Antitumor Agents ◽  
Potential Antitumor
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