ChemInform Abstract: The Complex Between Carboxypeptidase A and a Possible Transition-State Analogue: Mechanistic Inferences from High-Resolution X-Ray Structures of Enzyme-Inhibitor Complexes.

1986 ◽  
Vol 17 (50) ◽  
Author(s):  
D. W. CHRISTIANSON ◽  
W. N. LIPSCOMB
Keyword(s):  
High Resolution ◽  
Transition State ◽  
Enzyme Inhibitor ◽  
Carboxypeptidase A ◽  
X Ray ◽  
Transition State Analogue

Reaction Mechanism of Glyoxalase I Explored by an X-ray Crystallographic Analysis of the Human Enzyme in Complex with a Transition State Analogue†

Biochemistry ◽  
1999 ◽  
Vol 38 (41) ◽  
pp. 13480-13490 ◽  
Author(s):  
Alexander D. Cameron ◽  
Marianne Ridderström ◽  
Birgit Olin ◽  
Malcolm J. Kavarana ◽  
Donald J. Creighton ◽  
...  
Keyword(s):  
Reaction Mechanism ◽  
Transition State ◽  
Crystallographic Analysis ◽  
Glyoxalase I ◽  
X Ray ◽  
Human Enzyme ◽  
Transition State Analogue

Development of transition state analogue inhibitors for N-acetylglycosyltransferases bearing D-psicoor D-tagatofuranose scaffolds

2015 ◽  
Vol 69 (2) ◽  
Author(s):  
Marek Baráth ◽  
Chun-Hung Lin ◽  
Igor Tvaroška ◽  
Ján Hirsch
Keyword(s):  
Transition State ◽  
Optical Rotation ◽  
Enzymatic Reaction ◽  
Biological Assays ◽  
X Ray ◽  
X Ray Crystallography ◽  
Anomeric Configuration ◽  
Transition State Analogue ◽  
Proposed Model ◽  
Transition State Analogue Inhibitors

AbstractNew potential transition state analogue inhibitors for N-acetylglucosyltransferases (GnTs) were synthesised. These compounds based on psico- and tagatofuranose (structure) scaffold contained a 2-thiophenyl-1-O-diethylphosphate moiety mimicking the proposed model of the transition state of the enzymatic reaction catalysed by N-acetylglucosyltransferases. The synthesised compounds as well as their precursors were fully characterised by NMR, optical rotation and mass techniques. Anomeric configuration of tagatofuranose derivatives was confirmed by X-ray crystallography. Two types of potential human glycosyltransferase (GnTs) inhibitors representing donor UDP-GlcNAc, assigned for biological assays on human GnTs, were prepared.

Picomolar Transition State Analogue Inhibitors of Human 5‘-Methylthioadenosine Phosphorylase and X-ray Structure with MT-Immucillin-A†

Biochemistry ◽  
2004 ◽  
Vol 43 (1) ◽  
pp. 9-18 ◽  
Author(s):  
Vipender Singh ◽  
Wuxian Shi ◽  
Gary B. Evans ◽  
Peter C. Tyler ◽  
Richard H. Furneaux ◽  
...  
Keyword(s):  
Transition State ◽  
X Ray ◽  
Methylthioadenosine Phosphorylase ◽  
Transition State Analogue ◽  
Transition State Analogue Inhibitors
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