ChemInform Abstract: The Structure of Leudrin, and the Nucleophilic Substitution of Its Primary Hydroxy Group by Bromine.

ChemInform ◽  
1988 ◽  
Vol 19 (30) ◽  
Author(s):  
G. W. PEROLD ◽  
L. CARLTON ◽  
A. S. HOWARD ◽  
J. P. MICHAEL
Keyword(s):  
Nucleophilic Substitution ◽  
Hydroxy Group ◽  
Primary Hydroxy Group

Direct Etherification of a Single Primary Hydroxy Group of β-Cyclodextrin

2021 ◽  
Vol 57 (1) ◽  
pp. 121-125
Author(s):  
N. V. Kutyasheva ◽  
G. I. Kurochkina ◽  
E. A. Solomatin ◽  
M. K. Grachev
Keyword(s):  
Hydroxy Group ◽  
Primary Hydroxy Group

scholarly journals Spin-labeling of Dexamethasone: Radical Stability vs. Temporal Resolution of EPR-Spectroscopy on Biological Samples

2018 ◽  
Vol 232 (5-6) ◽  
pp. 883-891 ◽  
Author(s):  
Karolina A. Walker ◽  
Michael L. Unbehauen ◽  
Silke B. Lohan ◽  
Siavash Saeidpour ◽  
Martina C. Meinke ◽  
...  
Keyword(s):  
Detection Limit ◽  
Hydroxy Group ◽  
Epr Spectroscopy ◽  
Biological Samples ◽  
Spin Labeling ◽  
Hacat Cells ◽  
Nmr Data ◽  
Primary Hydroxy Group ◽  
High Yields ◽  
Stability Measurements

AbstractSpin-labeling active compounds is a convenient way to prepare them for EPR spectroscopy with minimal alteration of the target molecule. In this study we present the labeling reaction of dexamethasone (Dx) with either TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy) or PCA (3-(carboxy)-2,2,5,5-tetramethyl-1-pyrrolidinyloxy) with high yields. According to NMR data, both labels are attached at the primary hydroxy group of the steroid. In subsequent spin-stability measurements both compounds were applied onto HaCaT cells. When the signal of Dx-TEMPO decreased below the detection limit within 3 h, the signal of Dx-PCA remained stable for the same period of time.

Preparation and Conformational Study of B-Ring Substituted Lupane Derivatives

2006 ◽  
Vol 71 (8) ◽  
pp. 1131-1160 ◽  
Author(s):  
Martin Dračínský ◽  
Simona Hybelbauerová ◽  
Jan Sejbal ◽  
Miloš Buděšínský
Keyword(s):  
Double Bond ◽  
Hydroxy Group ◽  
Molecular Modelling ◽  
Nmr Spectra ◽  
Hydroxy Derivative ◽  
Secondary Hydroxy Group ◽  
Conformational Study ◽  
Primary Hydroxy Group ◽  
Type 3 ◽  
C Nmr

New lupane-type triterpenoids with 5(6) double bond were prepared using the method of partial demethylation on carbon C-4. Hydroboration of the double bond led to 6α-hydroxy derivative. By the oxidation and following reduction of 6α-hydroxy derivative the 6-oxo and 6β-hydroxy derivatives were prepared. A new method for selective oxidation of secondary hydroxy group in the presence of primary hydroxy group was performed. The conformation of ring A of new lupane-type 3-oxo derivatives with a substituent on ring B was elucidated on the bases of 1H and 13C NMR spectra and molecular modelling.

A METHOD FOR PREPARATION OF DROSERONE FROM PLUMBAGIN

INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (05) ◽  
pp. 53-56
Author(s):  
G.M Ferreira ◽  
◽  
K.S. Laddha
Keyword(s):  
Nucleophilic Substitution ◽  
Spectral Data ◽  
Hydroxy Group ◽  
13C Nmr ◽  
Plumbago Zeylanica ◽  
1H And 13C Nmr ◽  
Naturally Occurring ◽  
Rp Hplc

Droserone (2,5-dihyrdoxy-3-methyl-1,4- naphthoquinone) was prepared from naturally occurring naphthoquinone plumbagin. Plumbagin was isolated from roots of Plumbago zeylanica. Plumbagin was first brominated at C-3 which was subsequently substituted with hydroxy group by a nucleophilic substitution to obtain Droserone. The synthesized compounds were characterized by IR, MS, 1H and 13C NMR spectral data. RP-HPLC was used to ascertain the purity of the obtained compound.

ChemInform Abstract: Iron(III)-Catalyzed Nucleophilic Substitution of the Hydroxy Group in Benzoin by Alcohols.

ChemInform ◽  
2012 ◽  
Vol 43 (32) ◽  
pp. no-no
Author(s):  
Anvar Mirzaei ◽  
Srijit Biswas ◽  
Joseph S. M. Samec
Keyword(s):  
Nucleophilic Substitution ◽  
Hydroxy Group
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