ChemInform Abstract: A General Synthetic Approach to Optically Active Iridoid Aglycones. The Total Syntheses of β-Ethyl Descarbomethoxyverbenalol, Ethyl Catalpol, and (-)-Specionin.

ChemInform ◽  
1988 ◽  
Vol 19 (44) ◽  
Author(s):  
B. H. KIM ◽  
P. B. JACOBS ◽  
R. L. ELLIOTT ◽  
D. P. CURRAN
Keyword(s):  
Optically Active ◽  
Synthetic Approach ◽  
Total Syntheses

scholarly journals Total Syntheses of Pladienolide-Derived Spliceosome Modulators

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5938
Author(s):  
Jaehoon Sim ◽  
Eunbin Jang ◽  
Hyun Jin Kim ◽  
Hongjun Jeon
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Structural Features ◽  
Synthetic Approach ◽  
Synthetic Analog ◽  
Phase I Clinical Trials ◽  
Total Syntheses ◽  
Naturally Occurring ◽  
Anti Cancer ◽  
Synthetic Approaches

Pladienolides, an emerging class of naturally occurring spliceosome modulators, exhibit interesting structural features, such as highly substituted 12-membered macrocycles and epoxide-containing diene side chains. The potential of pladienolides as anti-cancer agents is confirmed by H3B-8800, a synthetic analog of this natural product class, which is currently under Phase I clinical trials. Since its isolation in 2004 and the first total synthesis in 2007, a dozen total syntheses and synthetic approaches toward the pladienolide class have been reported to date. This review focuses on the eight completed total syntheses of naturally occurring pladienolides or their synthetic analogs, in addition to a synthetic approach to the main framework of the natural product.

scholarly journals Total Syntheses of the C19 Diterpenoid Alkaloids (–)-Talatisamine, (–)-Liljestrandisine, and (–)-Liljestrandinine by a Fragment Coupling Approach

2021 ◽  
Author(s):  
Alice Wong ◽  
Nicholas Fastuca ◽  
Victor Mak ◽  
Jeff Kerkovius ◽  
Susan Stevenson ◽  
...  
Keyword(s):  
Original Structure ◽  
Synthetic Approach ◽  
Diterpenoid Alkaloids ◽  
Total Syntheses ◽  
Pinacol Rearrangement ◽  
Coupling Approach ◽  
Structure Assignment

<p>The C19 aconitine-type diterpenoid alkaloids (–)-talatisamine, (–)-liljestrandisine, and (–)-liljestrandinine have been prepared in 31, 30, and 33 steps, respectively, from phenol. The synthetic approach features a 1,2-addition/semi-pinacol rearrangement as the key fragment coupling tactic. These efforts have also resulted in a correction to the original structure assignment of (–)-liljestrandisine.</p>

Total syntheses of optically active natural isotetrandrine, phaeanthine and tetrandrine

1968 ◽  
Vol 9 (30) ◽  
pp. 3399-3402 ◽  
Author(s):  
Y. Inubushi ◽  
Y. Masaki ◽  
S. Matsumoto ◽  
F. Takami
Keyword(s):  
Optically Active ◽  
Total Syntheses ◽  
Active Natural

A general synthetic approach to optically active iridoid aglycones

Tetrahedron ◽  
1988 ◽  
Vol 44 (11) ◽  
pp. 3079-3092 ◽  
Author(s):  
Byeang Hyean Kim ◽  
Patricia B. Jacobs ◽  
Richard L. Elliott ◽  
Dennis P. Curran
Keyword(s):  
Optically Active ◽  
Synthetic Approach

ChemInform Abstract: Synthetic Approach to Optically Active 3-Aryl-3,4-dihydroisocoumarins.

ChemInform ◽  
2010 ◽  
Vol 24 (17) ◽  
pp. no-no
Author(s):  
A. ARNOLDI ◽  
A. BASSOLI ◽  
L. MERLINI ◽  
E. RAGG
Keyword(s):  
Optically Active ◽  
Synthetic Approach
Sign in / Sign up

Export Citation Format

Share Document