Several angularly functionalized decalins, synthethized during the preparation of three keto diacetate decalins, models for clerodane diterpenoids, were tested for antifeedant activity against the spruce budworm, Choristoneura fumiferana. Definite biological activity was observed for some of these compounds. A structure–activity relationship was discussed on the basis of these results.
Several compounds, each possessing a polyoxygenated decalin structure, were synthesized and tested for antifeedant activities against the spruce budworm, Choristoneurafumiferana. Definite biological activity was observed for some of these compounds. A structure–activity relationship was discussed on the basis of these results. Keywords: decalin, synthesis, antifeedant, spruce budworm.
A quantitative structure–activity relationship study was performed for a number of aroylhydrazine compounds with respect to their biological activity against spruce budworm. It was found that the biological activity can be modulated by substituents on the aromatic rings. Substituents with high π value and small L value lead to increase in biological activity. Molecular mechanics calculations were used to explain how the active compounds may mimic the strong-binding Y region of ecdysone. Keywords: spruce budworm, ecdysone, agonist, hydrazines, quantitative structure–activity relationship.