The flavonoids by their natural properties and their diverse applications are a group of
compounds whose study of origin, characteristics and applications has been dedicated to extensive
research. For the organic synthesis of chalcones, due to their interest as precursor molecules of different
compounds, several pathways have been developed and reported in numerous works. Analyses
on the effect of some of these catalysts on chalcone yield (%), with respect to time and reaction temperature
are presented here. Given the importance of flavon-3-ols, as compounds of pharmacological
interest mainly, new synthesis routes are proposed, in addition to the existing ones. This paper presents
the main pathways for the synthesis of chalcones and analyzes their production. New routes for
the synthesis of flavon-3-ols that follow the Claisen-Schmidt condensation and the interconversion of
melacacidin are proposed.
A System Fusing Computational and Information Chemistry for Developing New Synthesis Routes of Compounds