ChemInform Abstract: Synthetic Approaches to the Angucycline Antibiotics: The Total Syntheses of (.+-.)-Rubiginone B1 and B2, (.+-.)-Emycin A, and Related Analogues.

ChemInform ◽  
2010 ◽  
Vol 26 (33) ◽  
pp. no-no
Author(s):  
D. S. LARSEN ◽  
M. D. O'SHEA
Keyword(s):  
Total Syntheses ◽  
Synthetic Approaches ◽  
Angucycline Antibiotics

Recent Advances in the Total Synthesis of Clavaminols

Synthesis ◽  
2018 ◽  
Vol 50 (23) ◽  
pp. 4569-4576
Author(s):  
Tian Jin ◽  
Lu Zhao ◽  
Zhe-Bin Zheng ◽  
Xiao Liu ◽  
Liang Sun ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Research Groups ◽  
Total Syntheses ◽  
New Class ◽  
Recent Advances ◽  
Molecular Architectures ◽  
Synthetic Approaches ◽  
Long Chain

Clavaminols are a new class of long-chain 2-amino-3-­alkanols that mostly contain 2R,3S-configurations. Owing to their interesting molecular architectures and promising activities, they have ­become popular targets for synthetic organic chemists. In this review, we highlight 12 total syntheses of clavaminols from different research groups during the period 2009 to 2018.1 Introduction2 Synthetic Approaches toward Clavaminols2.1 Total Synthesis by Chemla and Colleagues (2009)2.2 Total Synthesis by Greck and Colleagues (2010)2.3 Total Synthesis by Sutherland and Zaed (2011)2.4 Total Synthesis by Huang and Colleagues (2011)2.5 Total Synthesis by Kotora and Colleagues (2012)2.6 Total Synthesis by Kumar and Colleagues (2013)2.7 Total Synthesis by Prabhavathi Devi and Colleagues (2013 and 2016)2.8 Total Synthesis by Sarabia and Colleagues (2014)2.9 Total Synthesis by Mohapatra and Colleagues (2016)2.10 Total Synthesis by Lu and Colleagues (2016)2.11 Total Synthesis by Jin and Colleagues (2017)2.12 Total Synthesis by Kumar Pandey and Colleagues (2018)3 Conclusion

scholarly journals Total Syntheses of Pladienolide-Derived Spliceosome Modulators

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5938
Author(s):  
Jaehoon Sim ◽  
Eunbin Jang ◽  
Hyun Jin Kim ◽  
Hongjun Jeon
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Structural Features ◽  
Synthetic Approach ◽  
Synthetic Analog ◽  
Phase I Clinical Trials ◽  
Total Syntheses ◽  
Naturally Occurring ◽  
Anti Cancer ◽  
Synthetic Approaches

Pladienolides, an emerging class of naturally occurring spliceosome modulators, exhibit interesting structural features, such as highly substituted 12-membered macrocycles and epoxide-containing diene side chains. The potential of pladienolides as anti-cancer agents is confirmed by H3B-8800, a synthetic analog of this natural product class, which is currently under Phase I clinical trials. Since its isolation in 2004 and the first total synthesis in 2007, a dozen total syntheses and synthetic approaches toward the pladienolide class have been reported to date. This review focuses on the eight completed total syntheses of naturally occurring pladienolides or their synthetic analogs, in addition to a synthetic approach to the main framework of the natural product.

scholarly journals Synthetic approaches and total syntheses of vinigrol, a unique diterpenoid

Tetrahedron ◽  
2015 ◽  
Vol 71 (23) ◽  
pp. 3775-3793 ◽  
Author(s):  
Cristian Draghici ◽  
Jon T. Njardarson
Keyword(s):  
Total Syntheses ◽  
Synthetic Approaches

ChemInform Abstract: Mitomycinoid Alkaloids: Mechanism of Action, Biosynthesis, Total Syntheses, and Synthetic Approaches

ChemInform ◽  
2013 ◽  
Vol 44 (41) ◽  
pp. no-no
Author(s):  
Phillip D. Bass ◽  
Daniel A. Gubler ◽  
Ted C. Judd ◽  
Robert M. Williams
Keyword(s):  
Mechanism Of Action ◽  
Total Syntheses ◽  
Synthetic Approaches

Concise Synthetic Approaches for the Laurencia Family: Formal Total Syntheses of (±)-Laurefucin and (±)-E- and (±)-Z-Pinnatifidenyne

2012 ◽  
Vol 134 (42) ◽  
pp. 17714-17721 ◽  
Author(s):  
Scott A. Snyder ◽  
Alexandria P. Brucks ◽  
Daniel S. Treitler ◽  
Ioana Moga
Keyword(s):  
Total Syntheses ◽  
Synthetic Approaches

Studies Towards the Synthesis of (+)- and (–)-Anisomycin and Their Analogues

Synthesis ◽  
2017 ◽  
Vol 50 (01) ◽  
pp. 17-34 ◽  
Author(s):  
Arun Shaw ◽  
Sama Ajay
Keyword(s):  
Biological Activity ◽  
Total Synthesis ◽  
Present Review ◽  
Formal Synthesis ◽  
Total Syntheses ◽  
Synthetic Approaches

Anisomycin shows potent biological activity and it has attracted much attention since its isolation in 1954, with around 13 total syntheses and 20 formal syntheses, and also two reports concerning analogues of anisomycin, reported to date. The present review highlights all of these synthetic approaches (around 35) to the total or formal synthesis of anisomycin along with its isomers and analogues.1 Introduction2 Isolation and Therapeutic Importance3 Total Synthesis of (+)-, (–)-, and (±)-Anisomycins and Their Analogues4 Formal Synthesis of (+)- and (–)-Anisomycins and Their Analogues5 Conclusion

scholarly journals Mitomycinoid Alkaloids: Mechanism of Action, Biosynthesis, Total Syntheses, and Synthetic Approaches

2013 ◽  
Vol 113 (8) ◽  
pp. 6816-6863 ◽  
Author(s):  
Phillip D. Bass ◽  
Daniel A. Gubler ◽  
Ted C. Judd ◽  
Robert M. Williams
Keyword(s):  
Mechanism Of Action ◽  
Total Syntheses ◽  
Synthetic Approaches
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