ChemInform Abstract: A Convenient Approach to Diastereomerically Pure 1,3,4-Trisubstituted Pyrrolidin-2-ones by Intramolecular Cyclization of N-(2-Alken-1-yl) amides Mediated by Mn(III). An Entry to Both (R)- and (S)-3- Pyrrolidineacetic Acid.

ChemInform ◽  
2010 ◽  
Vol 27 (17) ◽  
pp. no-no
Author(s):  
R. GALEAZZI ◽  
G. MOBBILI ◽  
M. ORENA
Keyword(s):  
Intramolecular Cyclization ◽  
Convenient Approach

Expeditious Scalable Catalyst-Free One-Pot Synthesis of 4-Alkoxy-5-amino-3-methylthiophene-2-carbonitriles via Sequential Reactions­ of Lithiated Alkoxyallenes with Isothiocyanates and 2-Bromoacetonitrile

Synthesis ◽  
2018 ◽  
Vol 50 (09) ◽  
pp. 1891-1900 ◽  
Author(s):  
Nina Nedolya ◽  
Boris Trofimov ◽  
Olga Tarasova ◽  
Alexander Albanov
Keyword(s):  
Intramolecular Cyclization ◽  
Thiophene Ring ◽  
One Pot ◽  
One Pot Synthesis ◽  
Convenient Approach ◽  
Reaction Proceeds ◽  
Sequential Addition ◽  
In Situ Formation ◽  
Cyano Groups

A synthetically simple and convenient approach to tetrasubstituted thiophenes with rare combination of the alkoxy, amino, and cyano groups has been developed. The assembly of polyfunctionalized thiophene ring is implemented in one preparative step by sequential addition of isothiocyanate and 2-bromoacetonitrile to the lithiated (with n-BuLi) alkoxyallene. The reaction proceeds through in situ formation and intramolecular cyclization of cyanomethyl 2-alkoxy-N-buta-2,3-dienimidothioate (1-aza-1,3,4-triene).

scholarly journals Novel Convenient Approach to 6-, 7-, and 8-Numbered Nitrogen Heterocycles Incorporating Endocyclic Sulfonamide Fragment

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2887
Author(s):  
Oleksandr Shalimov ◽  
Eduard Rusanov ◽  
Oksana Muzychka ◽  
Petro Onys’ko
Keyword(s):  
Intramolecular Cyclization ◽  
Lewis Acids ◽  
Nitrogen Heterocycles ◽  
The Other ◽  
Other Hand ◽  
Convenient Approach ◽  
Imidoyl Chloride ◽  
Electrophilic Heterocyclization ◽  
Derivatives Of

A new effective method for the construction of nitrogen heterocycles incorporating endocyclic pharmacophore sulfonamide fragment, based on the use of easy accessible N-(chlorosulfonyl)imidoyl chloride, CCl3C(Cl)=NSO2Cl (1), has been developed. Thus, a reaction of 1 as bielectrophilic 1,3-C–N–S reagent with benzylamines that act as 1,4-N–C–C-C binucleophiles, affords respective 1,2,4-benzothiadiazepine-1,1-dioxides. On the other hand, 1 reacts with alkenyl amines with the formation of respective N-alkenyl amidines undergoing Lewis acids initiated intramolecular cyclization to afford derivatives of 1,2,4-thiadiazines and 1,2,4-thiadiazocines bearing a halomethyl group able for further functionalization. The first examples of electrophilic heterocyclization of the chlorosulfonyl group onto an alkenyl or alkynyl group have been revealed.

Concise Synthesis of GB22 by Endo-Selective Siloxycyclopropane Arylation

2019 ◽  
Author(s):  
Hannah E. Burdge ◽  
Takuya Oguma ◽  
Takahiro Kawajiri ◽  
Ryan Shenvi
Keyword(s):  
Intramolecular Cyclization ◽  
Cross Coupling ◽  
Building Blocks ◽  
Ring Expansion ◽  
Dual Catalysis ◽  
Acid Labile

<div><div><div><p>The first synthesis of GB22 was accomplished by a con- cise, modular route. Two building blocks converged in a novel sp3-sp2 attached-ring coupling that used Ir/Ni dual-catalysis to reverse the regioselectivity of siloxycy- clopropane arylation. This cross-coupling proved general to access β-substituted tetralones via ring-expansion of indanone-derived siloxycyclopropanes. The congested, bridging rings of the GB alkaloids were completed using an aluminum-HFIP complex that effected intramolecular cyclization of an acid-labile substrate.</p></div></div></div>

Concise Synthesis of GB22 by Endo-Selective Siloxycyclopropane Arylation

2019 ◽  
Author(s):  
Hannah E. Burdge ◽  
Takuya Oguma ◽  
Takahiro Kawajiri ◽  
Ryan Shenvi
Keyword(s):  
Intramolecular Cyclization ◽  
Cross Coupling ◽  
Building Blocks ◽  
Ring Expansion ◽  
Dual Catalysis ◽  
Acid Labile

<div><div><div><p>The first synthesis of GB22 was accomplished by a con- cise, modular route. Two building blocks converged in a novel sp3-sp2 attached-ring coupling that used Ir/Ni dual-catalysis to reverse the regioselectivity of siloxycy- clopropane arylation. This cross-coupling proved general to access β-substituted tetralones via ring-expansion of indanone-derived siloxycyclopropanes. The congested, bridging rings of the GB alkaloids were completed using an aluminum-HFIP complex that effected intramolecular cyclization of an acid-labile substrate.</p></div></div></div>

Cyclopropyl→cyclobutyl rearrangement in intramolecular cyclization of 3,5-bridged B-secoandrostane-6,7(or 5,7)-diols and mass spectra of products

1982 ◽  
Vol 47 (8) ◽  
pp. 2280-2290 ◽  
Author(s):  
Helena Velgová ◽  
Jorga Smolíková ◽  
Antonín Trka ◽  
Antonín Vítek
Keyword(s):  
Intramolecular Cyclization ◽  
Mass Spectra ◽  
Acid Catalyzed

Acid-catalyzed intramolecular cyclization of 6,7-dihydroxy-3α,5-cyclo-6,7-seco-5α-androstan-17-one (VII), 5,7-dihydroxy-3,5-methylene-5,7-secoandrostan-17-one and 5,7-dihydroxy-3β,5-cyclo-5,7-seco-A-homo-5β-androstan-17-one (XIII) in benzene and dioxane was investigated. The main cyclization products were 3,5-methylene-6-oxaandrostan-17-one (I) and/or 3β,5-cyclo-6-oxa-A-homo-5β-androstan-17-one (VIII). In the case of VI and VII the ratio of I and VIII was solvent-dependent: in benzene more VIII was formed than in dioxane. The mass spectra of I and VIII were almost identical and corresponded to the structure VIII.

ChemInform Abstract: INTRAMOLECULAR CYCLIZATION IN REACTIONS OF BICYCLIC DIEPOXIDES WITH DIMETHYLAMINE

1985 ◽  
Vol 16 (9) ◽  
Author(s):  
L. I. KAS'YAN ◽  
N. S. ZEFIROV ◽  
N. V. STEPANOVA ◽  
L. E. SALTYKOVA ◽  
O. L. RYZHIK
Keyword(s):  
Intramolecular Cyclization

scholarly journals Easily accessible non-aromatic heterocycles with handles: 4-Bromo-2,3-dihydrofurans from 1,2-dibromohomoallylic alcohols

2021 ◽  
Author(s):  
Jason An ◽  
Jose Intano ◽  
Alissa Richard ◽  
Taehyun Kim ◽  
Jose Gascon ◽  
...  
Keyword(s):  
Intramolecular Cyclization ◽  
Aromatic Heterocycles

The first general preparation of 4-bromo-2,3-dihydrofurans is reported. These non-aromatic heterocyles containing a useful coupling handle are accessed via Cu-catalyzed intramolecular cyclization of 1,2-dibromohomoallylic alcohols, which are themselves available in...

Correlation Between Ion Gel Characteristics and Performance of Ionic Pressure Sensors

2021 ◽  
Author(s):  
Woo Young Lee ◽  
Yong Min Kim ◽  
Jin Han Kwon ◽  
Hong Chul Moon
Keyword(s):  
Ionic Liquid ◽  
Pressure Sensors ◽  
Convenient Approach ◽  
Ion Gel ◽  
And Performance ◽  
Ion Gels

In this study, a convenient approach is proposed to tune the properties of ion gels by utilizing mixed ionic liquid (IL) systems. Herein, a binary IL system consisting of 1-butyl-3-methylimidazolium...

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