scholarly journals Novel Convenient Approach to 6-, 7-, and 8-Numbered Nitrogen Heterocycles Incorporating Endocyclic Sulfonamide Fragment

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2887
Author(s):  
Oleksandr Shalimov ◽  
Eduard Rusanov ◽  
Oksana Muzychka ◽  
Petro Onys’ko
Keyword(s):  
Intramolecular Cyclization ◽  
Lewis Acids ◽  
Nitrogen Heterocycles ◽  
The Other ◽  
Other Hand ◽  
Convenient Approach ◽  
Imidoyl Chloride ◽  
Electrophilic Heterocyclization ◽  
Derivatives Of

A new effective method for the construction of nitrogen heterocycles incorporating endocyclic pharmacophore sulfonamide fragment, based on the use of easy accessible N-(chlorosulfonyl)imidoyl chloride, CCl3C(Cl)=NSO2Cl (1), has been developed. Thus, a reaction of 1 as bielectrophilic 1,3-C–N–S reagent with benzylamines that act as 1,4-N–C–C-C binucleophiles, affords respective 1,2,4-benzothiadiazepine-1,1-dioxides. On the other hand, 1 reacts with alkenyl amines with the formation of respective N-alkenyl amidines undergoing Lewis acids initiated intramolecular cyclization to afford derivatives of 1,2,4-thiadiazines and 1,2,4-thiadiazocines bearing a halomethyl group able for further functionalization. The first examples of electrophilic heterocyclization of the chlorosulfonyl group onto an alkenyl or alkynyl group have been revealed.

scholarly journals II. Compounds isomeric with the sulphocyanic ethers.—I. On the mustard oil of the ethyl series

1868 ◽  
Vol 16 ◽  
pp. 254-258
Keyword(s):  
Royal Society ◽  
The Other ◽  
Mustard Oil ◽  
Other Hand ◽  
Derivatives Of

The results of my researches on the chloroform-derivatives of the primary monamines, which, as I have shown, are isomeric with the nitriles, could not fail to direct my attention to allied groups of bodies, with the view of discovering similar isomerisms. In a note communicated to the Royal Society some months ago, I expressed the expectations which even then appeared to be justified in the following manner:—“In conclusion, I may be permitted to announce as everv probable the existence of a series of bodies isomeric with the sulphocyanides. Already M. Cloëz has shown that the action of chloride of cyanogen on ethylate of potassium gives rise to the formation of an ethylic cyanate possessing properties absolutely different from those belonging to the cyanate discovered by M. Wurtz. On comparing, on the other hand the properties of the methylic and ethylic sulphocyamdes with those of the sulphocyanides of allyl and phenyl, it can scarcely be doubted that we have here the representatives of two groups entirely different, and that the terms of the methyl- and ethyl-series which correspond to oil of mustard, and to the sulphocyanide of phenyl, still remain to be discovered. Experiments with which I am now engaged will show whether these bodies cannot be obtained by the action of the iodides of methyl and ethyl on sulphocyanide of silver."

Application of Maple on Solving the Differential Problem of Rational Functions

2013 ◽  
Vol 479-480 ◽  
pp. 855-860
Author(s):  
Chii Huei Yu
Keyword(s):  
Problem Solving ◽  
Research Methods ◽  
Research Method ◽  
Rational Functions ◽  
The Other ◽  
Mathematical Software ◽  
Differential Problem ◽  
Binomial Theorem ◽  
Other Hand ◽  
Derivatives Of

This paper uses the mathematical software Maple as the auxiliary tool to study the differential problem of four types of rational functions. We can obtain the closed forms of any order derivatives of these rational functions by using binomial theorem. On the other hand, we propose four examples to do calculation practically. The research methods adopted in this study involved finding solutions through manual calculations and verifying these solutions by using Maple. This type of research method not only allows the discovery of calculation errors, but also helps modify the original directions of thinking from manual and Maple calculations. For this reason, Maple provides insights and guidance regarding problem-solving methods.

Arylhydrazonothiazolidinones: Ring Cleavage and Alkylation of the 5-Arylhydrazono Derivatives of Rhodanine and Isorhodanine

1979 ◽  
Vol 34 (3) ◽  
pp. 507-510 ◽  
Author(s):  
Nazmi A. Kassab ◽  
Sanaa O. Abd Allah ◽  
Said A. Elbahaii
Keyword(s):  
Hydrazine Hydrate ◽  
The Other ◽  
Ring Cleavage ◽  
Ethyl Bromoacetate ◽  
Other Hand ◽  
Alkyl Derivatives ◽  
Derivatives Of

Abstract The 5-arylhydrazono derivatives of rhodanine and isorhodanine were subjected to the action of hydrazine hydrate to afford the arylhydrazonomercaptomethyl-triazolinones (3) and -triazolinthiones (3) respectively. Treatment of 1 with benzylamine afforded thioxalic acid dibenzylamide (5). On the other hand treatment of 2 with the same reagent afforded the corresponding benzylimino derivatives (6).Alkylation of 1 and 2 with ethyl bromoacetate and chloroacetamide yielded the corresponding S-alkyl derivatives (7) and (8), respectively.

Polyhedral boron derivatives of porphyrins and phthalocyanines

2001 ◽  
Vol 05 (11) ◽  
pp. 767-781 ◽  
Author(s):  
VLADIMIR I. BREGADZE ◽  
IGOR B. SIVAEV ◽  
DETLEF GABEL ◽  
DIETER WÖHRLE
Keyword(s):  
Neutron Capture ◽  
Tumor Therapy ◽  
The Other ◽  
Medical Applications ◽  
Neutron Capture Therapy ◽  
Current Interest ◽  
Boron Compounds ◽  
Other Hand ◽  
The One ◽  
Derivatives Of

The synthesis of compounds containing polyhedral boron cages and porphyrin or phthalocyanine units connected covalently in one molecule is reviewed. The importance of these compounds arises, on the one hand, from the use of polyhedral boron derivatives in neutron capture therapy for cancer; on the other hand, porphyrins and phthalocyanines are known as photosensitizers in photodynamic tumor therapy. Current interest in the binding of polyhedral boron compounds to porphyrins and phthalocyanines is due to the observation that porphyrins and phthalocyanines show improved uptake and good persistence in tissues. Medical applications of compounds containing polyhedral boron cages and porphyrin or phthalocyanine units in one molecule are briefly discussed.

scholarly journals Charge transfer control by substituents: Donor pyrroles and fluoro-anilines

2005 ◽  
Vol 7 (3) ◽  
pp. 121-124 ◽  
Author(s):  
Antje Neubauer ◽  
Sukumaran Murali ◽  
Wolfgang Rettig
Keyword(s):  
Charge Transfer ◽  
Benzene Ring ◽  
The Other ◽  
Substituted Benzenes ◽  
Other Hand ◽  
Alkane Solvents ◽  
New Compounds ◽  
Derivatives Of ◽  
Acceptor Moiety ◽  
Donor Substituent

Derivatives of N-phenyl pyrrole with a para-donor substituent on the acceptor benzene ring are compared. It is shown that by a suitable increase of the donor strength of the pyrrolo group, CT fluorescence can be achieved even for donor-donor substituted benzenes. On the other hand, introducing fluoro substituents into the acceptor moiety strongly enhances the CT formation tendency, and several new compounds with CT fluorescence even in alkane solvents are presented.

scholarly journals Theory of the Icon of Christos Yannaras

2021 ◽  
Vol 4 ◽  
pp. 64-69
Author(s):  
Tina Mosiakina
Keyword(s):  
The Other ◽  
Surrounding World ◽  
Other Hand ◽  
The Aesthetic ◽  
Theological Thought ◽  
Derivatives Of ◽  
The Erotic

The article regards the phenomenon of the icon in the interpretation of Greek theologian and philosopher Christos Yannaras. His work Personality and Eros is taken as a basis, where the author describes this phenomenon, based on a thorough body of works of Orthodox thought.The icon is primarily considered not only as a model of reality, reflection or image of events and objects, or allegory-allegory; attention is focused on the icon as a category of cognition. The study traces the conditions of functioning of the iconological language, as well as its connection with apophatic and cataphatic theological thought. The specifics of the poetics of the iconological language are also revealed, aiming at both concealment and elucidation of the truth.An attempt is also made to transfer the theory of the icon to the anthropological plane, in accordance with the erotic gesture of self-denial. The focus is on the aesthetic component of the iconic perception not only of icons but also of other phenomena of art or the surrounding world. Thus, owing to the derivatives of the theory of the icon, the analysis of art in the anthropological plane is carried out.Possible types of reduction of the iconological language according to the function of the icon as a means of cognition are also revealed. In this regard, the significance of the so-called ‘theology of assimilation’ and its possible connection with the moralistic reduction in the interpretation of Ch. Yannaras are analyzed. On the other hand, aesthetic reduction is also described, which, in turn, has the ability to provoke iconoclastic resistance.Thus, the aim of the work is to study the phenomenon of the icon as a category of knowledge in the works of Ch. Yannaras, as well as to consider the icon and the iconological language in their connection with issues of the aesthetic and anthropological nature.

Nucleoside Derivatives of 1,2,4-Triazine Reaction of Some Derivatives of 1,2,4-Triazine with Tetra-O-acetyl-α-D-glucopyranosyl Bromide

1976 ◽  
Vol 31 (4) ◽  
pp. 505-508 ◽  
Author(s):  
A. K. Mansoub ◽  
Y. A. Ibrahim ◽  
M. M. Eid
Keyword(s):  
Pyruvic Acid ◽  
The Other ◽  
Ethyl Iodide ◽  
Other Hand ◽  
Derivatives Of

4,6-Diphenyl-, 6-phenyl-4-p-tolyl- and 6-styryl-4-phenyl-3-thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazines (1 a-c) react with tetra-0-acetyl-α-D-glucopyranosyl bromide (2) to give the corresponding 2-tetra-0-acetyl-B-D-glucopyranosyl derivatives (4a-c), respectively. Oxidation of 4a with H2O2 gives the 3,5-dioxo derivative (7). On the other hand deacetylation of 4a affords 2-B-D-glucopyranosyl-4,6-diphenyl-3-thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazine (8). Furfurylidene pyruvic acid condenses with 4-phenylthiosemicarbazide to give 6-furfurylidene-4-phenyl-3-thioxo-5-oxo-2, 3, 4, 5-tetrahydro-1, 2, 4-triazine (1d). 1d reacts with ethyl iodide to give the 3-ethylmercapto derivative (9), and reacts with 2 to give 4d.

Synthesis and antibacterial activity of some 1-(2-propynyl) and 1-propadienyl derivatives of 1,4-dihydro-4-oxoquinoline-3-carboxylic acids and similar heterocycles

1991 ◽  
Vol 56 (2) ◽  
pp. 439-448 ◽  
Author(s):  
Stanislav Rádl ◽  
Lenka Kovářová ◽  
Jiří Holoubek
Keyword(s):  
Antibacterial Activity ◽  
Dimethyl Sulfoxide ◽  
Carboxylic Acids ◽  
Potassium Carbonate ◽  
Potassium Hydroxide ◽  
Room Temperature ◽  
Ethyl Esters ◽  
The Other ◽  
Other Hand ◽  
Derivatives Of

N-Alkylation of IIIa, IIIb, IIId - IIIf and 9-acridanone with 3-bromopropyne in dimethyl sulfoxide in the presence of potassium carbonate yielded N-(2-propynyl) derivatives IVa - IVe and VIa, respectively. Ethyl esters IVa, IVb, and IVe were hydrolyzed to IVf - IVh, respectively. Compounds IVf, IVg, IVctreated with bases yielded N-propadienyl derivatives Va - Vc. On the other hand 2-substituted compounds IVd and IVh did not change under the same conditions. Compound VIa treated with powdered potassium hydroxide in dimethyl sulfoxide at room temperature yielded N-(1-propynyl) derivative VII.

3D Euler deconvolution: Theoretical basis for automatically selecting good solutions

Geophysics ◽  
2003 ◽  
Vol 68 (6) ◽  
pp. 1962-1968 ◽  
Author(s):  
João B. C. Silva ◽  
Valéria C. F. Barbosa
Keyword(s):  
Magnetic Anomaly ◽  
Theoretical Basis ◽  
Source Location ◽  
The Other ◽  
Euler Deconvolution ◽  
Data Window ◽  
Other Hand ◽  
3D Euler Deconvolution ◽  
Structural Indices ◽  
Derivatives Of

We derive the analytical estimators for the horizontal and vertical source positions in 3D Euler deconvolution as a function of the x‐, y‐, and z‐derivatives of the magnetic anomaly within a data window. From these expressions we show that, in the case of noise‐corrupted data, the x‐, y‐, and z‐coordinate estimates computed at the anomaly borders are biased toward the respective horizontal coordinate of the data window center regardless of the true or presumed structural indices and regardless of the magnetization inclination and declination. On the other hand, in the central part of the anomaly, the x‐ and y‐coordinate estimates are very close to the respective source horizontal coordinates regardless of the true or presumed structural indices and regardless of the magnetization inclination and declination. This contrasting behavior of the horizontal coordinate estimates may be used to automatically delineate the region associated with the best solutions. Applying the Euler deconvolution operator inside this region would decrease the dispersion of all position estimates, improving source location precision.

Synthesis of 5-tert-butyl-8,12,14-trimethyl- and 5-tert-butyl-8,12,14,16-tetramethyl[2.2]metacyclophane and their treatment with Lewis acids in benzene

2009 ◽  
Vol 2009 (7) ◽  
pp. 443-447 ◽  
Author(s):  
Tomoe Shimizu ◽  
Katsuhiko Hida ◽  
Takehiko Yamato
Keyword(s):  
Good Yield ◽  
Lewis Acids ◽  
The Other ◽  
Tert Butyl ◽  
Other Hand

Treatment of 5- tert-butyl-8,12,14,16-tetramethyl[2.2]MCP with AlCl3-MeNO2 in benzene led to trans- tert-butylation to afford 8,12,14,16-tetramethyl[2.2]MCP in good yield along with tert-butylbenzene. On the other hand, the same treatment of 5- tert-butyl-8,12,14-trimethyl[2.2]MCP led to transannular cyclisation reaction and isomerisation reaction to afford the corresponding strainless 2- tert-butyl-3a,6,8-trimethyl-3,3a,4,5,9,10-hexahydropyrene in good yield.

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