ChemInform Abstract: Quinone-Annonaceous Acetogenins: Synthesis and Complex I Inhibition Studies of a New Class of Natural Product Hybrids.

ChemInform ◽  
2010 ◽  
Vol 33 (5) ◽  
pp. no-no
Author(s):  
Sabine Arndt ◽  
Ulrich Emde ◽  
Stefan Baeurle ◽  
Thorsten Friedrich ◽  
Lutz Grubert ◽  
...  
Keyword(s):  
Natural Product ◽  
Complex I ◽  
Annonaceous Acetogenins ◽  
New Class ◽  
Inhibition Studies

Quinone-Annonaceous Acetogenins: Synthesis and Complex I Inhibition Studies of a New Class of Natural Product Hybrids

2001 ◽  
Vol 7 (5) ◽  
pp. 993-1005 ◽  
Author(s):  
Sabine Arndt ◽  
Ulrich Emde ◽  
Stefan Bäurle ◽  
Thorsten Friedrich ◽  
Lutz Grubert ◽  
...  
Keyword(s):  
Natural Product ◽  
Complex I ◽  
Annonaceous Acetogenins ◽  
New Class ◽  
Inhibition Studies

scholarly journals Natural product-inspired aryl isonitriles as a new class of antimalarial compounds against drug-resistant parasites

2020 ◽  
Vol 28 (19) ◽  
pp. 115678 ◽  
Author(s):  
Kwaku Kyei-Baffour ◽  
Dexter C. Davis ◽  
Zarko Boskovic ◽  
Nobutaka Kato ◽  
Mingji Dai
Keyword(s):  
Natural Product ◽  
Drug Resistant ◽  
New Class ◽  
Antimalarial Compounds

Heterocyclic Analogues of Squamocin as Inhibitors of Mitochondrial Complex I. On the Role of the Terminal Lactone of Annonaceous Acetogenins

Biochemistry ◽  
2006 ◽  
Vol 45 (8) ◽  
pp. 2721-2728 ◽  
Author(s):  
Romain A. Duval ◽  
Guy Lewin ◽  
Eva Peris ◽  
Nadia Chahboune ◽  
Aurelio Garofano ◽  
...  
Keyword(s):  
Complex I ◽  
Mitochondrial Complex I ◽  
Mitochondrial Complex ◽  
Annonaceous Acetogenins

ChemInform Abstract: Synthesis of Annonaceous Acetogenins and Their Inhibitory Action with Mitochondrial Complex I

ChemInform ◽  
2011 ◽  
Vol 42 (41) ◽  
pp. no-no
Author(s):  
Yasunao Hattori ◽  
Hiroyuki Konno ◽  
Hideto Miyoshi ◽  
Hidefumi Makabe
Keyword(s):  
Complex I ◽  
Inhibitory Action ◽  
Mitochondrial Complex I ◽  
Mitochondrial Complex ◽  
Annonaceous Acetogenins

Discovery of a New Class of Natural Product-Inspired Quinazolinone Hybrid as Potent Antileishmanial agents

2013 ◽  
Vol 56 (11) ◽  
pp. 4374-4392 ◽  
Author(s):  
Moni Sharma ◽  
Kuldeep Chauhan ◽  
Rahul Shivahare ◽  
Preeti Vishwakarma ◽  
Manish K. Suthar ◽  
...  
Keyword(s):  
Natural Product ◽  
New Class

scholarly journals Biosynthesis of fosfomycin in pseudomonads reveals an unexpected enzymatic activity in the metallohydrolase superfamily

2021 ◽  
Vol 118 (23) ◽  
pp. e2019863118
Author(s):  
Max A. Simon ◽  
Chayanid Ongpipattanakul ◽  
Satish K. Nair ◽  
Wilfred A. van der Donk
Keyword(s):  
Enzymatic Activity ◽  
Natural Product ◽  
Pseudomonas Syringae ◽  
Broad Spectrum ◽  
Plant Pathogen ◽  
Biosynthetic Pathway ◽  
Systematic Evaluation ◽  
Oxidative Decarboxylation ◽  
Broad Spectrum Antibiotic ◽  
New Class

The epoxide-containing phosphonate natural product fosfomycin is a broad-spectrum antibiotic used in the treatment of cystitis. Fosfomycin is produced by both the plant pathogen Pseudomonas syringae and soil-dwelling streptomycetes. While the streptomycete pathway has recently been fully elucidated, the pseudomonad pathway is still mostly elusive. Through a systematic evaluation of heterologous expression of putative biosynthetic enzymes, we identified the central enzyme responsible for completing the biosynthetic pathway in pseudomonads. The missing transformation involves the oxidative decarboxylation of the intermediate 2-phosphonomethylmalate to a new intermediate, 3-oxo-4-phosphonobutanoate, by PsfC. Crystallographic studies reveal that PsfC unexpectedly belongs to a new class of diiron metalloenzymes that are part of the polymerase and histidinol phosphatase superfamily.

Advances in the 1-phenanthryl-tetrahydroisoquinoline series of PAK4 inhibitors: potent agents restrain tumor cell growth and invasion

2016 ◽  
Vol 14 (32) ◽  
pp. 7676-7690 ◽  
Author(s):  
Chenzhou Hao ◽  
Xiaodong Li ◽  
Shuai Song ◽  
Bingyu Guo ◽  
Jing Guo ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Natural Product ◽  
Tumor Cell Growth ◽  
New Class ◽  
Anti Cancer

Discovery of a new class of natural product-inspired PAK4 inhibitors as potent anti-cancer agents.

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