Hydrogenation of C=C bond and reductive amination is important transformation utilized in chemistry. An efficient and facile one-pot transfer hydrogenation of C=C bond and reductive amination of C=N bond of enones and amines was reported using the iridium complexes as catalysts and formic acid as hydrogen source in aqueous medium, which shows environmentally friendly. In this catalytic system, a wide range of α-alkylated amine compounds were obtained in excellent yields by one-pot transfer hydrogenation of C=C bond and reductive amination. The practical application of this protocol is characterized by gram-scale transformation.