A One-Pot Process for the Enantioselective Synthesis of Amines via Reductive Amination under Transfer Hydrogenation Conditions

2003 ◽  
Vol 5 (22) ◽  
pp. 4227-4230 ◽  
Author(s):  
Glynn D. Williams ◽  
Richard A. Pike ◽  
Charles E. Wade ◽  
Martin Wills
Keyword(s):  
Reductive Amination ◽  
Enantioselective Synthesis ◽  
Transfer Hydrogenation ◽  
One Pot

scholarly journals Intramolecular asymmetric reductive amination: synthesis of enantioenriched dibenz[c,e]azepines

2019 ◽  
Vol 10 (8) ◽  
pp. 2473-2477 ◽  
Author(s):  
Tao Yang ◽  
Xiaochong Guo ◽  
Qin Yin ◽  
Xumu Zhang
Keyword(s):  
Reductive Amination ◽  
Enantioselective Synthesis ◽  
One Pot

An enantioselective synthesis of dibenz[c,e]azepines containing both central and axial chiralities through a one pot N-Boc deprotection/intramolecular asymmetric reductive amination sequence has been achieved with generally excellent enantiocontrol (up to 97% ee).

A one-pot process for the enantioselective synthesis of tetrahydroquinolines and tetrahydroisoquinolines via asymmetric reductive amination (ARA)

2018 ◽  
Vol 54 (52) ◽  
pp. 7247-7250 ◽  
Author(s):  
Tao Yang ◽  
Qin Yin ◽  
Guoxian Gu ◽  
Xumu Zhang
Keyword(s):  
Catalytic System ◽  
Reductive Amination ◽  
Enantioselective Synthesis ◽  
One Pot

Asymmetric reductive amination for the synthesis of both chiral tetrahydroquinolines and tetrahydroisoquinolines has been realized with an Ir/ZhaoPhos catalytic system via a one-pot N-Boc deprotection/intramolecular asymmetric reductive amination (ARA) sequence.

Construction of α-alkylated amines by Iridium Complexes-Catalyzed One-Step Transfer Hydrogenation of C=C and C=N Bond

Synthesis ◽  
2020 ◽  
Author(s):  
Yanping Xia ◽  
Lu Ouyang ◽  
Jianhua Liao ◽  
Xiao Yang ◽  
Renshi Luo
Keyword(s):  
Reductive Amination ◽  
Transfer Hydrogenation ◽  
Scale Transformation ◽  
Iridium Complexes ◽  
Practical Application ◽  
One Pot ◽  
System A ◽  
Wide Range ◽  
One Step ◽  
Amine Compounds

Hydrogenation of C=C bond and reductive amination is important transformation utilized in chemistry. An efficient and facile one-pot transfer hydrogenation of C=C bond and reductive amination of C=N bond of enones and amines was reported using the iridium complexes as catalysts and formic acid as hydrogen source in aqueous medium, which shows environmentally friendly. In this catalytic system, a wide range of α-alkylated amine compounds were obtained in excellent yields by one-pot transfer hydrogenation of C=C bond and reductive amination. The practical application of this protocol is characterized by gram-scale transformation.

Enantioselective Synthesis of 2-Substituted Pyrrolidines via Intramolecular­ Reductive Amination

Synthesis ◽  
2019 ◽  
Vol 51 (13) ◽  
pp. 2713-2719
Author(s):  
Huan Zhou ◽  
Wenlei Zhao ◽  
Tao Zhang ◽  
Haodong Guo ◽  
Haizhou Huang ◽  
...  
Keyword(s):  
Reductive Amination ◽  
Enantioselective Synthesis ◽  
One Pot ◽  
Tert Butyl

Catalyzed by the complex generated in situ from iridium and the chiral ferrocene ligand, tert-butyl (4-oxo-4-arylbutyl)carbamate substrates were deprotected and then reductively cyclised to form 2-substituted arylpyrrolidines in a one-pot manner, in which the intramolecular reductive amination was the key step. A range of chiral 2-substituted arylpyrrolidines were synthesised in up to 98% yield and 92% ee.

Influence of metal oxide and heteropoly tungustate location in mesoporous silica towards catalytic transfer hydrogenation of furfural to γ-valerolactone

2021 ◽  
Author(s):  
Bolla Srinivasarao ◽  
Yogita Y ◽  
Dhana Lakshmi Darsi ◽  
Krishna Kumari Pamula ◽  
N. Lingaiah
Keyword(s):  
Mesoporous Silica ◽  
Metal Oxide ◽  
Transfer Hydrogenation ◽  
Catalytic Transfer Hydrogenation ◽  
One Pot ◽  
Catalytic Transfer

One pot conversion of furfural to -valerolactone by transfer hydrogenation has been achieved over bifunctional Zr and TPA located in mesoporous silica catalysts. Different catalysts with TPA and ZrO2 located...

Enantioselective synthesis of tetrahydroisoquinolines via catalytic intramolecular asymmetric reductive amination

2021 ◽  
Author(s):  
Ruixia Liu ◽  
Jingkuo Han ◽  
Bin Li ◽  
Xian Liu ◽  
Zhao Wei ◽  
...  
Keyword(s):  
Reductive Amination ◽  
Enantioselective Synthesis ◽  
Iridium Complex ◽  
Highly Efficient ◽  
Efficient Access

A highly efficient intramolecular asymmetric reductive amination transformation catalyzed by an iridium complex of tBu-ax-Josiphos has been realized, providing an efficient access to various THIQ alkaloids.

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