Discovery of Embelin as a Cell-Permeable, Small-Molecular Weight Inhibitor of XIAP Through Structure-Based Computational Screening of a Traditional Herbal Medicine Three-Dimensional Structure Database.

ChemInform ◽  
2004 ◽  
Vol 35 (37) ◽  
Author(s):  
Shaomeng Wang ◽  
et al. et al.
Keyword(s):  
Molecular Weight ◽  
Herbal Medicine ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Traditional Herbal Medicine ◽  
Small Molecular Weight ◽  
Three Dimensional Structure ◽  
Computational Screening ◽  
Structure Database ◽  
A Cell

scholarly journals KNApSAcK-3D: A Three-Dimensional Structure Database of Plant Metabolites

2013 ◽  
Vol 54 (2) ◽  
pp. e4-e4 ◽  
Author(s):  
Kensuke Nakamura ◽  
Naoki Shimura ◽  
Yuuki Otabe ◽  
Aki Hirai-Morita ◽  
Yukiko Nakamura ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Dimensional Structure ◽  
Plant Metabolites ◽  
Three Dimensional Structure ◽  
Structure Database

scholarly journals TIPdb-3D: the three-dimensional structure database of phytochemicals from Taiwan indigenous plants

Database ◽  
2014 ◽  
Vol 2014 (0) ◽  
pp. bau055-bau055 ◽  
Author(s):  
C.-W. Tung ◽  
Y.-C. Lin ◽  
H.-S. Chang ◽  
C.-C. Wang ◽  
I.-S. Chen ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Dimensional Structure ◽  
Indigenous Plants ◽  
Three Dimensional Structure ◽  
Structure Database

The Three-dimensional structure of frozen-hydrated nudaurelia capensis β virus

1987 ◽  
Vol 45 ◽  
pp. 650-651
Author(s):  
N. H. Olson ◽  
T. S. Baker ◽  
Wu Bo Mu ◽  
J. E. Johnson ◽  
D. A. Hendry
Keyword(s):  
South African ◽  
Rna Virus ◽  
Carbon Film ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Electron Dose ◽  
Total Electron ◽  
Three Dimensional Structure ◽  
Negative Stain ◽  
Dimensional Reconstruction

Nudaurelia capensis β virus (NβV) is an RNA virus of the South African Pine Emperor moth, Nudaurelia cytherea capensis (Lepidoptera: Saturniidae). The NβV capsid is a T = 4 icosahedron that contains 60T = 240 subunits of the coat protein (Mr = 61,000). A three-dimensional reconstruction of the NβV capsid was previously computed from visions embedded in negative stain suspended over holes in a carbon film. We have re-examined the three-dimensional structure of NβV, using cryo-microscopy to examine the native, unstained structure of the virion and to provide a initial phasing model for high-resolution x-ray crystallographic studiesNβV was purified and prepared for cryo-microscopy as described. Micrographs were recorded ∼1 - 2 μm underfocus at a magnification of 49,000X with a total electron dose of about 1800 e-/nm2.

Three Dimensional structure and organization of diploid chromosomes by optical section microscopy

1987 ◽  
Vol 45 ◽  
pp. 633-635
Author(s):  
David A. Agard ◽  
Yasushi Hiraoka ◽  
John W. Sedat
Keyword(s):  
Dimensional Space ◽  
Three Dimensional ◽  
Developmental State ◽  
Mitotic Cell ◽  
Biological Properties ◽  
Dimensional Structure ◽  
Specific Gene ◽  
Three Dimensional Structure ◽  
Complementary Techniques ◽  
Dynamic Structures

In an effort to understand the complex relationship between structure and biological function within the nucleus, we have embarked on a program to examine the three-dimensional structure and organization of Drosophila melanogaster embryonic chromosomes. Our overall goal is to determine how DNA and proteins are organized into complex and highly dynamic structures (chromosomes) and how these chromosomes are arranged in three dimensional space within the cell nucleus. Futher, we hope to be able to correlate structual data with such fundamental biological properties as stage in the mitotic cell cycle, developmental state and transcription at specific gene loci.Towards this end, we have been developing methodologies for the three-dimensional analysis of non-crystalline biological specimens using optical and electron microscopy. We feel that the combination of these two complementary techniques allows an unprecedented look at the structural organization of cellular components ranging in size from 100A to 100 microns.

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