Discovering Drugs Through Biological Transformation: Role of Pharmacologically Active Metabolites in Drug Discovery

Marine organisms are a source of natural products and produce compounds with a molecular structure that is unique and useful. Thousands of new compounds have biological activitity for anticancer, antiviral, and antimicrobial. This compounds isolated from various marine organism, including from marine-derived fungi. Investigation of chemical compounds from marine-derived fungi isolated from sponge has increased steadily, indicating the important role of marine-derived fungi in the discovery of drug compounds. The sponge has produced various kinds of fungi, which have reported to provide a variety of pharmacologically active metabolites and structurally diverse. Study literature showed that many fungal genera isolated from the marine sponge dominated the genus Acremonium, Aspergillus, Penicillium, Phoma, and Fusarium. The high proportion of genera and new compounds showed that the fungi isolated from the sponge could develop.

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ChemInform Abstract: Pharmacologically Active Metabolites of Currently Marketed Drugs: Potential Resources for New Drug Discovery and Development

ChemInform ◽

10.1002/chin.201111268 ◽

2011 ◽

Vol 42 (11) ◽

pp. no-no

Author(s):

Myug Joo Kang ◽

Woo Heon Song ◽

Byung Ho Shim ◽

Seung Youn Oh ◽

Hyun Young Lee ◽

...

Keyword(s):

Drug Discovery ◽

Active Metabolites ◽

Drug Discovery And Development ◽

New Drug ◽

Pharmacologically Active

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Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2014.06.012 ◽

2014 ◽

Vol 22 (16) ◽

pp. 4453-4461 ◽

Cited By ~ 12

Author(s):

Elizabeth M. Kigondu ◽

Antonina Wasuna ◽

Digby F. Warner ◽

Kelly Chibale

Keyword(s):

Drug Discovery ◽

Drug Repositioning ◽

Target Identification ◽

Antituberculosis Drug ◽

Active Metabolites ◽

Pharmacologically Active

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Pharmacologically Active Metabolites of Currently Marketed Drugs: Potential Resources for New Drug Discovery and Development

YAKUGAKU ZASSHI ◽

10.1248/yakushi.130.1325 ◽

2010 ◽

Vol 130 (10) ◽

pp. 1325-1337 ◽

Cited By ~ 16

Author(s):

Myung Joo KANG ◽

Woo Heon SONG ◽

Byung Ho SHIM ◽

Seung Youn OH ◽

Hyun Young LEE ◽

...

Keyword(s):

Drug Discovery ◽

Active Metabolites ◽

Drug Discovery And Development ◽

New Drug ◽

Pharmacologically Active

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Faculty Opinions recommendation of The role of ligand efficiency metrics in drug discovery.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718258486.793498346 ◽

2014 ◽

Author(s):

Mark Murcko

Keyword(s):

Drug Discovery ◽

Ligand Efficiency

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Faculty of 1000 evaluation for The role of ligand efficiency metrics in drug discovery.

F1000 - Post-publication peer review of the biomedical literature ◽

10.3410/f.718410892.793498346 ◽

2014 ◽

Author(s):

Mark Murcko

Keyword(s):

Drug Discovery ◽

Ligand Efficiency

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Faculty Opinions recommendation of Role of molecular dynamics and related methods in drug discovery.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726100159.793514134 ◽

2016 ◽

Author(s):

John Lowe

Keyword(s):

Molecular Dynamics ◽

Drug Discovery

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Hypothetical Role of Growth Factors to Reduce Intervertebral Disc Degeneration Significantly through Trained Biological Transformations

Current Pharmaceutical Design ◽

10.2174/1381612826666201019104201 ◽

2020 ◽

Vol 26 ◽

Author(s):

Cristian Muresanu ◽

Siva G. Somasundaram ◽

Sergey V. Vissarionov ◽

Liliya V. Gavryushova ◽

Vladimir N. Nikolenko ◽

...

Keyword(s):

Growth Factors ◽

Blood Circulation ◽

Seminal Fluid ◽

Prostate Gland ◽

The Body ◽

Personal Experiences ◽

Biological Transformation ◽

The Mind

Background: From the evidence of failed injection-based growth factor therapies, it has been proposed that a naturally triggered uninterrupted blood circulation of the growth factors would be superior. Objective: We seek to stimulate discussions and more research about the possibility of using the already available growth factors found in the prostate gland and endometrium by starting a novel educable physiology, known as biological transformations controlled by the mind. Methods: We summarized the stretch-gated ion channel mechanism of the cell membrane, and offer several practical methods that can be applied by anyone, in order to stimulate and enhance the blood circulation of the growth factors from the seminal fluid to sites throughout the body. This details the practical application of our earlier published studies about biological transformations. Results: A previously reported single-patient case study has been extended, adding more from his personal experiences continually improving this novel physiological training and extending the ideas from our earlier findings in detail. Conclusion: The biological transformation findings demonstrate the need additional research to establish the benefits of these natural therapies to repair and rejuvenate tissues affected by various chronic diseases or aging processes.

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