Natural Compounds in Drug Discovery: Biological Activity and New Trends in the Chemistry of Isoquinoline Alkaloids

ChemInform ◽  
2006 ◽  
Vol 37 (7) ◽  
Author(s):  
V. G. Kartsev
2019 ◽  
Vol 19 (2) ◽  
pp. 114-118
Author(s):  
Gian Luigi Mariottini ◽  
Irwin Darren Grice

Natural compounds extracted from organisms and microorganisms are an important resource for the development of drugs and bioactive molecules. Many such compounds have made valuable contributions in diverse fields such as human health, pharmaceutics and industrial applications. Presently, however, research on investigating natural compounds from marine organisms is scarce. This is somewhat surprising considering that the marine environment makes a major contribution to Earth's ecosystems and consequently possesses a vast storehouse of diverse marine species. Interestingly, of the marine bioactive natural compounds identified to date, many are venoms, coming from Cnidarians (jellyfish, sea anemones, corals). Cnidarians are therefore particularly interesting marine species, producing important biological compounds that warrant further investigation for their development as possible therapeutic agents. From an experimental aspect, this review aims to emphasize and update the current scientific knowledge reported on selected biological activity (antiinflammatory, antimicrobial, antitumoral, anticoagulant, along with several less studied effects) of Cnidarian venoms/extracts, highlighting potential aspects for ongoing research towards their utilization in human therapeutic approaches.


Symmetry ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 546
Author(s):  
Miroslava Nedyalkova ◽  
Vasil Simeonov

A cheminformatics procedure for a partitioning model based on 135 natural compounds including Flavonoids, Saponins, Alkaloids, Terpenes and Triterpenes with drug-like features based on a descriptors pool was developed. The knowledge about the applicability of natural products as a unique source for the development of new candidates towards deadly infectious disease is a contemporary challenge for drug discovery. We propose a partitioning scheme for unveiling drug-likeness candidates with properties that are important for a prompt and efficient drug discovery process. In the present study, the vantage point is about the matching of descriptors to build the partitioning model applied to natural compounds with diversity in structures and complexity of action towards the severe diseases, as the actual SARS-CoV-2 virus. In the times of the de novo design techniques, such tools based on a chemometric and symmetrical effect by the implied descriptors represent another noticeable sign for the power and level of the descriptors applicability in drug discovery in establishing activity and target prediction pipeline for unknown drugs properties.


2012 ◽  
Vol 20 (11) ◽  
pp. 3596-3602 ◽  
Author(s):  
Gianluigi Lauro ◽  
Milena Masullo ◽  
Sonia Piacente ◽  
Raffaele Riccio ◽  
Giuseppe Bifulco

2012 ◽  
pp. 127-160 ◽  
Author(s):  
Arturo San Feliciano ◽  
María Á. Castro ◽  
José L. López-Pérez ◽  
Esther del Olmo

1979 ◽  
Vol 34 (7) ◽  
pp. 1024-1025 ◽  
Author(s):  
Kurt Geekeler ◽  
Manfred Mutter

Abstract The glycosidic component of cinerubin A, an anthracycline antibiotic, has been replaced by a polyoxyethylene (POE) chain. The resulting POE-bound e-pyrromycinone was readily soluble in water and exhibited full biological activity


2008 ◽  
Vol 7 (1) ◽  
pp. 84-99 ◽  
Author(s):  
Kishor M. Wasan ◽  
Dion R. Brocks ◽  
Stephen D. Lee ◽  
Kristina Sachs-Barrable ◽  
Sheila J. Thornton

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