Soluble Polymers for Substitute of Biopolymers in Natural Compounds, I Replacement of the Oligosaccharide Chain in Cinerubin A by Polyoxyethylene

1979 ◽  
Vol 34 (7) ◽  
pp. 1024-1025 ◽  
Author(s):  
Kurt Geekeler ◽  
Manfred Mutter
Keyword(s):  
Biological Activity ◽  
Natural Compounds ◽  
Anthracycline Antibiotic ◽  
Soluble Polymers ◽  
Oligosaccharide Chain

Abstract The glycosidic component of cinerubin A, an anthracycline antibiotic, has been replaced by a polyoxyethylene (POE) chain. The resulting POE-bound e-pyrromycinone was readily soluble in water and exhibited full biological activity

Natural Compounds and Drug Discovery: Can Cnidarian Venom Play a Role?

2019 ◽  
Vol 19 (2) ◽  
pp. 114-118
Author(s):  
Gian Luigi Mariottini ◽  
Irwin Darren Grice
Keyword(s):  
Biological Activity ◽  
Marine Species ◽  
Natural Compounds ◽  
Therapeutic Agents ◽  
Industrial Applications ◽  
Bioactive Molecules ◽  
Sea Anemones ◽  
Therapeutic Approaches ◽  
Ongoing Research ◽  
Biological Compounds

Natural compounds extracted from organisms and microorganisms are an important resource for the development of drugs and bioactive molecules. Many such compounds have made valuable contributions in diverse fields such as human health, pharmaceutics and industrial applications. Presently, however, research on investigating natural compounds from marine organisms is scarce. This is somewhat surprising considering that the marine environment makes a major contribution to Earth's ecosystems and consequently possesses a vast storehouse of diverse marine species. Interestingly, of the marine bioactive natural compounds identified to date, many are venoms, coming from Cnidarians (jellyfish, sea anemones, corals). Cnidarians are therefore particularly interesting marine species, producing important biological compounds that warrant further investigation for their development as possible therapeutic agents. From an experimental aspect, this review aims to emphasize and update the current scientific knowledge reported on selected biological activity (antiinflammatory, antimicrobial, antitumoral, anticoagulant, along with several less studied effects) of Cnidarian venoms/extracts, highlighting potential aspects for ongoing research towards their utilization in human therapeutic approaches.

Inverse Virtual Screening allows the discovery of the biological activity of natural compounds

2012 ◽  
Vol 20 (11) ◽  
pp. 3596-3602 ◽  
Author(s):  
Gianluigi Lauro ◽  
Milena Masullo ◽  
Sonia Piacente ◽  
Raffaele Riccio ◽  
Giuseppe Bifulco
Keyword(s):  
Biological Activity ◽  
Virtual Screening ◽  
Natural Compounds

scholarly journals STEROID CONJUGATES AS POTENTIAL ANTI-CANCER AGENTS

2020 ◽  
Vol 19 (1) ◽  
pp. 22-52
Author(s):  
V. A. Zolottsev ◽  
A. S. Latysheva ◽  
V. S. Pokrovsky ◽  
I. I. Khan ◽  
R. L. M. Almanza ◽  
...  
Keyword(s):  
Biological Activity ◽  
Natural Compounds ◽  
The Past ◽  
Anti Cancer ◽  
Steroid Conjugates

The review is dedicated to results of investigations of steroid conjugates published predominantly over the past decade. It consists of three parts in which the data concerning biological activity of steroid conjugates with known drugs, steroid dimers, and steroid conjugates with some natural compounds, their fragments and related derivatives and analogs, are discussed. The structures of 231 steroid conjugates and their anti-cancer properties are presented.

scholarly journals Potential inhibitors for SARS-CoV-2 Mpro from marine compounds

RSC Advances ◽  
2021 ◽  
Vol 11 (36) ◽  
pp. 22206-22213
Author(s):  
Nguyen Minh Tam ◽  
Minh Quan Pham ◽  
Huy Truong Nguyen ◽  
Nam Dao Hong ◽  
Nguyen Khoa Hien ◽  
...  
Keyword(s):  
Biological Activity ◽  
Natural Compounds ◽  
Main Protease ◽  
Marine Compounds ◽  
Potential Inhibitors

Preventing the biological activity of SARS-CoV-2 main protease using natural compounds is of great interest.

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