Structural—Activity Relationship Study on C-4 Carbon Atom of the CB1 Antagonist SR141716: Synthesis and Pharmacological Evaluation of 1,2,4-Triazole-3-carboxamides.

ChemInform ◽  
2006 ◽  
Vol 37 (27) ◽  
Author(s):  
Nadine Jagerovic ◽  
et al. et al.
Keyword(s):  
Carbon Atom ◽  
Activity Relationship ◽  
Pharmacological Evaluation ◽  
Structural Activity Relationship ◽  
Cb1 Antagonist ◽  
Relationship Study

Quantitative structural activity relationship study of bis-tetraazacyclic compounds. A novel series of HIV-1 and HIV-2 inhibitors

1995 ◽  
Vol 38 (19) ◽  
pp. 3865-3873 ◽  
Author(s):  
Heidi C. Joao ◽  
Karen De Vreese ◽  
Rudi Pauwels ◽  
Erik De Clercq ◽  
Geoff W. Henson ◽  
...  
Keyword(s):  
Activity Relationship ◽  
Structural Activity Relationship ◽  
Relationship Study ◽  
Quantitative Structural Activity Relationship ◽  
Hiv 1

scholarly journals An efficient synthesis of 4 H -pyrano quinolinone derivatives catalysed by a versatile organocatalyst tetra- n -butylammonium fluoride and their pharmacological screening

2017 ◽  
Vol 4 (11) ◽  
pp. 170764 ◽  
Author(s):  
Pratibha Prasad ◽  
Pratik G. Shobhashana ◽  
Manish P. Patel
Keyword(s):  
Aqueous Ethanol ◽  
Activity Relationship ◽  
Efficient Synthesis ◽  
One Pot ◽  
Experimental Procedure ◽  
Cyclocondensation Reaction ◽  
Structural Activity Relationship ◽  
Relationship Study ◽  
Bacteria And Fungi ◽  
Pharmacological Screening

A new series of indole-based pyranoquinoline derivatives P 1–24 has been synthesized by a one-pot cyclocondensation reaction of 2-(4-substituted)phenyl- N -allyl-indole-3-carbaldehydes 1a–d ; active methylenes 2a–c ; and 4-hydroxy-1-substituted quinolin-2(1 H )-one 3a–b catalysed by an organocatalyst tetra- n -butylammonium fluoride (TBAF) in aqueous ethanol. The easy experimental procedure of the reaction leads to excellent yields of pyranoquinoline derivatives. All the compounds were screened against a representative panel of bacteria and fungi. Some of the compounds are found to be equipotent or more potent than standard drugs as evident from the structural activity relationship study.

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