Synthesis of Spiro-pyridopyridine Analogues by Grubbs′ Catalyst Mediated Alkene and Enyne Metathesis Reaction.

ChemInform ◽  
2006 ◽  
Vol 37 (44) ◽  
Author(s):  
K. C. Majumdar ◽  
R. Islam ◽  
H. Rahaman ◽  
B. Roy
Keyword(s):  
Enyne Metathesis ◽  
Metathesis Reaction ◽  
Grubbs Catalyst

First Total Synthesis of a Fluorinated Calystegin

2010 ◽  
Vol 65 (4) ◽  
pp. 445-451 ◽  
Author(s):  
René Csuk ◽  
Erik Prell ◽  
Stefan Reißmann ◽  
Claudia Korb
Keyword(s):  
Total Synthesis ◽  
Ring Opening ◽  
Competitive Inhibitor ◽  
Ring Closure ◽  
Target Compound ◽  
Metathesis Reaction ◽  
Grubbs Catalyst ◽  
Ring Opening Reaction ◽  
Ultrasound Assisted ◽  
Key Steps

A straightforward chiral pool synthesis for the first fluorinated calystegin is described. Key steps of this synthesis include an ultrasound-assisted Zn-mediated tandem ring opening reaction followed by a Grubbs’ catalyst-mediated ring closure metathesis reaction. The target compound is a selective and competitive inhibitor for a β -glycosidase.

scholarly journals Synthesis of fluorinated δ-lactams via cycloisomerization of gem-difluoropropargyl amides

2010 ◽  
Vol 6 ◽  
Author(s):  
Satoru Arimitsu ◽  
Gerald B Hammond
Keyword(s):  
Building Blocks ◽  
Alder Reaction ◽  
Diels Alder ◽  
Tandem Reaction ◽  
Enyne Metathesis ◽  
Metathesis Reaction ◽  
Ring Closing Metathesis ◽  
Diels Alder Reaction

gem-Difluoro-1,7-enyne amides are suitable building blocks for the synthesis of difluorodihydropyridinones via a ring-closing metathesis reaction, and of 4,4-difluoro-3-oxoisoquinolines through a ring-closing metathesis–enyne metathesis tandem reaction. These products, in turn, undergo a Diels–Alder reaction to yield heterotricyclic systems in moderate to good yields.

ChemInform Abstract: Synthesis of Unusual α-Amino Acid Derivatives via Cross-Enyne Metathesis Reaction.

ChemInform ◽  
2000 ◽  
Vol 31 (39) ◽  
pp. no-no ◽  
Author(s):  
Sambasivarao Kotha ◽  
Somnath Halder ◽  
Enugurthi Brahmachary ◽  
Thota Ganesh
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Enyne Metathesis ◽  
Metathesis Reaction

A facile new procedure for the deprotection of allyl ethers under mild conditions

2000 ◽  
Vol 78 (6) ◽  
pp. 838-845 ◽  
Author(s):  
Yun-Jin Hu ◽  
Romyr Dominique ◽  
Sanjoy Kumar Das ◽  
René Roy
Keyword(s):  
Key Words ◽  
Catalytic System ◽  
Olefin Metathesis ◽  
Allyl Ether ◽  
Metathesis Reaction ◽  
Grubbs Catalyst ◽  
Allyl Ethers ◽  
Mild Conditions ◽  
Cross Metathesis ◽  
Allylic Ethers

A novel isomerization of O-allyl glycosides into prop-1-enyl glycosides was observed instead of cross-metathesis during an olefin metathesis reaction using Grubbs' ruthenium benzylidene catalyst (Cy3P)2RuCl2=CHPh (1), N-allyltritylamine, and N,N-diisopropylethylamine as necessary auxiliary reagents. In the search for a better catalytic system, it has been found that dichlorotris(triphenylphosphine)ruthenium(II), [(C6H5)3P]3RuCl2, (2) was much more efficient for the isomerization of allylic ethers. The labile prop-1-enyl group was easily hydrolyzed using HgCl2-HgO and the hemiacetals (25-32) were isolated in excellent yields (ca. 90%).Key words: allyl ether, carbohydrate, Grubbs' catalyst, isomerization, metathesis, deprotection.

Use of graphene oxide functionalized with Grubbs and Hoveyda Grubbs catalyst to activate metathesis reaction in epoxy mixtures

2014 ◽  
Author(s):  
Annaluisa Mariconda ◽  
Anna Agovino ◽  
Pasquale Longo ◽  
Marialuigia Raimondo ◽  
Liberata Guadagno
Keyword(s):  
Graphene Oxide ◽  
Metathesis Reaction ◽  
Grubbs Catalyst

scholarly journals Designing liquid-crystalline gold nanoparticles via the olefin cross-metathesis reaction

2016 ◽  
Vol 20 (08n11) ◽  
pp. 1060-1064 ◽  
Author(s):  
Thanh Tung Nguyen ◽  
Thi Le Anh Nguyen ◽  
Robert Deschenaux
Keyword(s):  
Gold Nanoparticles ◽  
Liquid Crystalline ◽  
Second Generation ◽  
Metathesis Reaction ◽  
Grubbs Catalyst ◽  
Terminal Olefin ◽  
Organic Shell ◽  
Smectic A ◽  
Cross Metathesis ◽  
Liquid Crystalline Nanoparticles

Liquid-crystalline gold nanoparticles were prepared by grafting mesomorphic [Formula: see text],[Formula: see text]-unsaturated carbonyl olefins onto the organic shell of gold nanoparticles containing terminal olefin ligands by applying the olefin cross-metathesis. The latter reaction was performed under standard conditions using second-generation Grubbs catalyst. The title materials were found to be stable up to 200[Formula: see text] C and gave rise to the formation of smectic A phases in agreement with the structure and nature of the liquid-crystalline promoters. The olefin cross-metathesis proved to be a reaction of choice for the design of liquid-crystalline nanoparticles.

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