ChemInform Abstract: Medicinal Chemistry Targeting Nucleosides and Nucleic Acids Based on Fine Synthetic Chemistry

ChemInform ◽  
2009 ◽  
Vol 40 (6) ◽  
Author(s):  
Satoshi Ichikawa
Keyword(s):  
Nucleic Acids ◽  
Medicinal Chemistry ◽  
Synthetic Chemistry

Microwave-Assisted Domino Cyclization Reactions

2021 ◽  
Vol 08 ◽  
Author(s):  
Yogesh B. Wagh ◽  
Dipak S. Dalal
Keyword(s):  
Microwave Irradiation ◽  
Molecular Diversity ◽  
Medicinal Chemistry ◽  
Complex Molecule ◽  
Complex Compounds ◽  
Synthetic Chemistry ◽  
Domino Reactions ◽  
Cyclization Reactions ◽  
Microwave Assisted ◽  
Synthetic Approaches

Background: Microwave-assisted domino cyclization reactions have attracted great interest for researchers to synthesize complex compounds in shorter times with increase yields. The domino reactions were used in various synthetic approaches and many drug deliveries in medicinal chemistry with microwave assisted approach. Methods: Microwave irradiation has been applied for the various domino reactions. The research related to microwave assisted domino cyclization was reviewed and the important methodologies are collected from 2011-2021. Results: Only those methodologies that involve microwave-assisted domino cyclization reactions during synthesis in a related manner have been reviewed. Along with some recent syntheses that are microwave-assisted regarding new heterocyclic moieties are summarized. Conclusion: Microwave-assisted domino cyclization reactions can be employed to quickly explore and increase molecular diversity in synthetic chemistry. We hope that this review will be helpful to find out complex molecule synthesis by microwave-assisted domino cyclization reactions. This review aimed to explain the applications of microwaves for the domino reactions from 2011-2021. In this respect, the microwave mediated methods help researchers to make helpful studies.

scholarly journals The Origin of Life on Earth and the Design of Alternative Life Forms

2017 ◽  
Vol 01 (02) ◽  
pp. 121-131 ◽  
Author(s):  
Jack W. Szostak
Keyword(s):  
Nucleic Acids ◽  
Origin Of Life ◽  
Artificial Life ◽  
Building Blocks ◽  
Life Forms ◽  
Chemical Energy ◽  
Synthetic Chemistry ◽  
Broad Scope ◽  
The Origin Of Life ◽  
Life On Earth

To understand the origin of life on Earth, and to evaluate the potential for life on exoplanets, we must understand the pathways that lead from chemistry to biology. Recent experiments suggest that a chemically rich environment that provides the building blocks of membranes, nucleic acids and peptides, along with sources of chemical energy, could result in the emergence of replicating, evolving cells. The broad scope of synthetic chemistry suggests that it may be possible to design and construct artificial life forms based upon a very different biochemistry than that of existing biology.

Medicinal Chemistry of Plasmid DNA with Peptide Nucleic Acids

2007 ◽  
pp. 195-211
Author(s):  
Olivier Zelphati ◽  
Jiin Felgner ◽  
Yan Wang ◽  
Xiaowu Liang ◽  
Xiaodong Wang ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Plasmid Dna ◽  
Medicinal Chemistry ◽  
Peptide Nucleic Acids

Medicinal chemistry of plasmid DNA with peptide nucleic acids: A new strategy for gene therapy

2003 ◽  
Vol 10 (3-4) ◽  
pp. 309-323 ◽  
Author(s):  
Olivier Zelphati ◽  
Jiin Felgner ◽  
Yan Wang ◽  
Xiaowu Liang ◽  
Xiaodong Wang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Nucleic Acids ◽  
Plasmid Dna ◽  
Medicinal Chemistry ◽  
Peptide Nucleic Acids ◽  
New Strategy
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