ChemInform Abstract: Isolation, Structure Elucidation, and Biological Evaluation of the Unusual Heterodimer Chrysoxanthone from the Ascomycete IBWF11-95A.

ChemInform ◽  
2009 ◽  
Vol 40 (48) ◽  
Author(s):  
Anja Schueffler ◽  
Johannes C. Liermann ◽  
Heinz Kolshorn ◽  
Till Opatz ◽  
Heidrun Anke
Keyword(s):  
Structure Elucidation ◽  
Biological Evaluation

scholarly journals The myxocoumarins A and B fromStigmatella aurantiacastrain MYX-030

2013 ◽  
Vol 9 ◽  
pp. 2579-2585 ◽  
Author(s):  
Tobias A M Gulder ◽  
Snežana Neff ◽  
Traugott Schüz ◽  
Tammo Winkler ◽  
René Gees ◽  
...  
Keyword(s):  
Natural Products ◽  
Structure Elucidation ◽  
Biological Evaluation ◽  
Biologically Active ◽  
Antifungal Properties ◽  
Structural Framework ◽  
Stigmatella Aurantiaca ◽  
Promising Source ◽  
Active Natural

The myxobacterial strainStigmatella aurantiacaMYX-030 was selected as promising source for the discovery of new biologically active natural products by our screening methodology. The isolation, structure elucidation and initial biological evaluation of the myxocoumarins derived from this strain are described in this work. These compounds comprise an unusual structural framework and exhibit remarkable antifungal properties.

The Structure Elucidation of Haprolid

Synthesis ◽  
2017 ◽  
Vol 50 (03) ◽  
pp. 529-538 ◽  
Author(s):  
Markus Kalesse ◽  
Jun Li ◽  
Jun Xing ◽  
Daniel Lücke ◽  
Dennis Lübken ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Structure Elucidation ◽  
Carcinoma Cell ◽  
Hidden Markov ◽  
Biological Evaluation ◽  
Terminal Olefin ◽  
Carcinoma Cell Lines ◽  
Hepatocellular Carcinoma Cell ◽  
Key Steps

The assignment of two stereocenters of the natural product haprolid through the application of a profile hidden Markov model (HMM) and its confirmation through total synthesis of the natural product and of two of its diastereomers are reported. The structure elucidation of this polyketide-peptide hybrid natural product is a telling showcase of how difficult it can be to determine the absolute configuration of isolated stereocenters and the benefits of a gene cluster analysis for structure determination. The key steps of the synthesis are a selective epoxidation of a terminal olefin and the stereodivergent macrolactonization strategy. Furthermore, the biological evaluation of all products showed that all diastereomers are potent inhibitors of hepatocellular carcinoma cell lines.

ChemInform Abstract: Synthesis, Structure Elucidation and Biological Evaluation of C- Norpaclitaxel.

ChemInform ◽  
2010 ◽  
Vol 27 (6) ◽  
pp. no-no
Author(s):  
X. LIANG ◽  
D. G. I. KINGSTON ◽  
B. H. LONG ◽  
C. A. FAIRCHILD ◽  
K. A. JOHNSTON
Keyword(s):  
Structure Elucidation ◽  
Biological Evaluation

scholarly journals Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei

2015 ◽  
Vol 10 (10) ◽  
pp. 2373-2381 ◽  
Author(s):  
Christopher J. Schulze ◽  
Mohamed S. Donia ◽  
Jair L. Siqueira-Neto ◽  
Debalina Ray ◽  
Jevgenij A. Raskatov ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Structure Elucidation ◽  
Biological Evaluation ◽  
Lead Discovery
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