ChemInform Abstract: Synthesis of Some Novel Benzofuran-2-yl(4,5-dihydro-3,5-substituted diphenylpyrazol-1-yl)methanones and Studies on the Antiproliferative Effects and Reversal of Multidrug Resistance of Human MDR1-Gene Transfected Mouse Lymphoma Cells

ChemInform ◽  
2011 ◽  
Vol 42 (32) ◽  
pp. no-no
Author(s):  
Anamik Shah ◽  
et al. et al.
Keyword(s):  
Multidrug Resistance ◽  
Mdr1 Gene ◽  
Lymphoma Cells ◽  
Antiproliferative Effects ◽  
Mouse Lymphoma Cells ◽  
Human Mdr1 ◽  
Mouse Lymphoma

Ecdysteroids reverse resistance of human mdr1 gene transfected mouse lymphoma cells

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
A Martins ◽  
N Tóth ◽  
J Molnár ◽  
J Hohmann ◽  
M Báthori ◽  
...  
Keyword(s):  
Mdr1 Gene ◽  
Lymphoma Cells ◽  
Mouse Lymphoma Cells ◽  
Human Mdr1 ◽  
Mouse Lymphoma

scholarly journals Reversal of Multidrug Resistance in Mouse Lymphoma Cells by Extracts and Flavonoids from Pistacia integerrima

2016 ◽  
Vol 17 (1) ◽  
pp. 51-55 ◽  
Author(s):  
Abdur Rauf ◽  
Ghias Uddin ◽  
Muslim Raza ◽  
Bashir Ahmad ◽  
Noor Jehan ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Lymphoma Cells ◽  
Mouse Lymphoma Cells ◽  
Mouse Lymphoma

scholarly journals Comparative Study on the MDR Reversal Effects of Selected Chalcones

2011 ◽  
Vol 2011 ◽  
pp. 1-7
Author(s):  
A. B. Ivanova ◽  
D. I. Batovska ◽  
I. T. Todorova ◽  
B. A. Stamboliyska ◽  
J. Serly ◽  
...  
Keyword(s):  
Positive Control ◽  
The Other ◽  
Lymphoma Cells ◽  
Lead Compounds ◽  
Structure Activity ◽  
Mouse Lymphoma Cells ◽  
Human Mdr1 ◽  
Mouse Lymphoma ◽  
Mdr Reversal

Based on the structure of three previously established lead compounds, fifteen selected chalcones were synthesized and evaluated for their multidrug resistance (MDR) reversal activity on mouse lymphoma cells. The most active chalcones were stronger revertants than the positive control, verapamil. In the model of combination chemotherapy, the interactions between the anticancer drug doxorubicin and two of the most effective compounds were measured in vitro, on human MDR1 gene transfected mouse lymphoma cells, showing that the type of interaction for one of these compounds was indifferent while that for the other one was additive. Furthermore, two chalcones inhibited 50% of cell proliferation in concentration of around 0.4 μg/mL and were from 2- to 100-fold more active than the most chalcones. The structure-activity relationships were obtained and discussed in view of their usefulness for the design of chalcone-like P-gp modulators and drugs able to treat resistant cancers.

Jatrophane Diterpenoids fromEuphorbiamongolicaas Modulators of the Multidrug Resistance of L5128 Mouse Lymphoma Cells

2003 ◽  
Vol 66 (7) ◽  
pp. 976-979 ◽  
Author(s):  
Judit Hohmann ◽  
Dóra Rédei ◽  
Peter Forgo ◽  
József Molnár ◽  
György Dombi ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Lymphoma Cells ◽  
Mouse Lymphoma Cells ◽  
Mouse Lymphoma
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