Ecdysteroids reverse resistance of human mdr1 gene transfected mouse lymphoma cells

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
A Martins ◽  
N Tóth ◽  
J Molnár ◽  
J Hohmann ◽  
M Báthori ◽  
...  
Keyword(s):  
Mdr1 Gene ◽  
Lymphoma Cells ◽  
Mouse Lymphoma Cells ◽  
Human Mdr1 ◽  
Mouse Lymphoma

scholarly journals Comparative Study on the MDR Reversal Effects of Selected Chalcones

2011 ◽  
Vol 2011 ◽  
pp. 1-7
Author(s):  
A. B. Ivanova ◽  
D. I. Batovska ◽  
I. T. Todorova ◽  
B. A. Stamboliyska ◽  
J. Serly ◽  
...  
Keyword(s):  
Positive Control ◽  
The Other ◽  
Lymphoma Cells ◽  
Lead Compounds ◽  
Structure Activity ◽  
Mouse Lymphoma Cells ◽  
Human Mdr1 ◽  
Mouse Lymphoma ◽  
Mdr Reversal

Based on the structure of three previously established lead compounds, fifteen selected chalcones were synthesized and evaluated for their multidrug resistance (MDR) reversal activity on mouse lymphoma cells. The most active chalcones were stronger revertants than the positive control, verapamil. In the model of combination chemotherapy, the interactions between the anticancer drug doxorubicin and two of the most effective compounds were measured in vitro, on human MDR1 gene transfected mouse lymphoma cells, showing that the type of interaction for one of these compounds was indifferent while that for the other one was additive. Furthermore, two chalcones inhibited 50% of cell proliferation in concentration of around 0.4 μg/mL and were from 2- to 100-fold more active than the most chalcones. The structure-activity relationships were obtained and discussed in view of their usefulness for the design of chalcone-like P-gp modulators and drugs able to treat resistant cancers.

scholarly journals Modes of shedding of glycosphingolipids from mouse lymphoma cells.

1986 ◽  
Vol 261 (5) ◽  
pp. 2279-2283
Author(s):  
W W Young ◽  
C A Borgman ◽  
D M Wolock
Keyword(s):  
Lymphoma Cells ◽  
Mouse Lymphoma Cells ◽  
Mouse Lymphoma

Mutagenicity of silver nanoparticles evaluated using whole-genome sequencing in mouse lymphoma cells

2021 ◽  
pp. 1-15
Author(s):  
Bohu Pan ◽  
Pravin R. Kaldhone ◽  
Alexander W. Alund ◽  
Hua Du ◽  
Xiaoqing Guo ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Whole Genome ◽  
Lymphoma Cells ◽  
Mouse Lymphoma Cells ◽  
Mouse Lymphoma
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