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Reactions in water have demonstrated numerous surprising results. The effects of water in these reactions may
include significant physical and chemical interactions with the substrates and catalysts through polar effects and hydrogen
bonding ability. In some instances, water is also able to interact with the intermediates of reactions and possibly with the
transition states of chemical processes. Organic synthesis in water encourages the researchers to follow the principles of
green chemistry. Among heterocyclic compounds, quinoline scaffold has become an important motif for the development of
new drugs. They are widely found in pharmaceuticals as well as in agrochemical industry. Over the last few decades, numerous
reports have been documented to access quinoline derivatives with structural diversity, either by new annulation or
by ring functionalization. This review summarizes an overview of the synthesis and functionalisation of quinoline scaffolds
in aqueous medium. This method may encourage researchers to adopt green chemistry and to apply these environmentally
safe methods in designing important heterocyclic cores.
Efficient synthesis of butyl levulinate from furfuryl alcohol over ordered mesoporous Ti-KIT-6 catalysts for green chemistry applications