Green synthesis of five- and six-membered N-heterocycles by ultrasonic irradiation in aqueous media

2021 ◽  
Vol 08 ◽  
Author(s):  
Thais Cristina Mendonça Nogueiraa ◽  
Marcus Vinicius Nora de Souza
Keyword(s):  
Green Chemistry ◽  
Green Synthesis ◽  
Ultrasonic Irradiation ◽  
Heterocyclic Compounds ◽  
Aqueous Media ◽  
Ultrasound Irradiation ◽  
New Drugs ◽  
Environmentally Benign ◽  
Water Conditions ◽  
Synthetic Methodologies

: Five- and six-membered N-heterocyclic compounds play an important role in medicinal chemistry and in the development of new drugs. In this manner, there is a constant demand for the development of novel biologically potent compounds and there is also an increasing pressure to develop alternative and more sustainable synthetic methodologies following the Green Chemistry principles. Thus, the present review aims to compile the latest progress in the use of ultrasound irradiation in water conditions to mediate the synthesis of five- and six-membered N-heterocyclic compounds in an environmentally benign manner.

scholarly journals Alum Catalyzed Simple, Efficient, and Green Synthesis of 2-[3-Amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic Acid Derivatives in Aqueous Media

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Harshita Sachdeva ◽  
Diksha Dwivedi ◽  
Rekha Saroj
Keyword(s):  
Amino Acids ◽  
Green Chemistry ◽  
Green Synthesis ◽  
Aqueous Media ◽  
Propanoic Acid ◽  
Ft Ir ◽  
C Nmr

Alum (KAl(SO4)2·12H2O) is an inexpensive, efficient, and nontoxic catalyst used for the synthesis of 2-[3-amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic acid derivatives in aqueous media by the reaction of 3-acetyl pyridine(1), amino acids(2)/(6), and thiosemicarbazide(4)at 80°C. This methodology offers significant improvements for the synthesis of products with regards to the yield of products, simplicity in operation, and green aspects by avoiding toxic catalysts which uphold the motto of green chemistry. Synthesized compounds have been characterized by FT-IR,13C NMR, and1HNMR spectroscopy.

Catalyst-free, one-pot, four-component green synthesis of functionalized 1-(2-fluorophenyl)-1,4-dihydropyridines under ultrasound irradiation

2016 ◽  
Vol 40 (6) ◽  
pp. 5107-5112 ◽  
Author(s):  
Nhlanhla Shabalala ◽  
Suresh Maddila ◽  
Sreekantha B. Jonnalagadda
Keyword(s):  
Green Synthesis ◽  
Ultrasonic Irradiation ◽  
Aqueous Ethanol ◽  
Ultrasound Irradiation ◽  
One Pot ◽  
Catalyst Free ◽  
New Compounds ◽  
Synthesis Protocol

A catalyst-free synthesis protocol for functionalized 1,4-dihydropyridines under ultrasonic irradiation in aqueous ethanol is reported with excellent yields. Eleven new compounds are synthesized using dimethylacetylenedicarboxylate, 2-fluoroaniline, malononitrile and various substituted aldehydes.

Green Synthesis of 4-aryl-3,4-Dihydrochromeno[3,4-e][1,3]Oxazine-2,5-Dione in Aqueous Media by Condensation of 4-Hydroxycoumarin with Aromatic Aldehydes and Methyl Carbamate

2017 ◽  
Vol 41 (3) ◽  
pp. 136-138 ◽  
Author(s):  
Sabereh Bougan ◽  
Alireza Hassanabadi
Keyword(s):  
Green Chemistry ◽  
Organic Solvent ◽  
Green Synthesis ◽  
Aqueous Media ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Efficient Synthesis ◽  
One Pot ◽  
Three Component Reaction ◽  
High Yields

A green and efficient synthesis of the title compounds has been achieved in a one-pot, three-component reaction of 4-hydroxycoumarin and aromatic aldehydes with methyl carbamate catalysed by p-toluenesulfonic acid in aqueous media to afford 4-aryl-3,4-dihydrochromeno[3,4-e][1,3]oxazine-2,5-diones in excellent yields. The salient features of this protocol are: short reaction times, high yields and absence of any hazardous organic solvent. Consequently, this procedure could be classified as green chemistry.

scholarly journals GREEN SYNTHESIS, GREEN CHEMISTRY, AND ENVIRONMENTAL SUSTAINABILITY

2021 ◽  
Vol 7 (1) ◽  
pp. 18-27
Author(s):  
Mohammad Asif
Keyword(s):  
Green Chemistry ◽  
Green Synthesis ◽  
Environmental Sustainability ◽  
Industrial Applications ◽  
Vital Role ◽  
New Drugs ◽  
Synthetic Methods ◽  
Synthesis Methods ◽  
Waste Products ◽  
By Products

Purpose: The chemistry society has activated to expand new chemistry that is less destructive to the environment and human health. This approach has extensive interest and designated as green chemistry, environmentally friendly chemistry, clean chemistry, and atom economy. Methodology: There is advancement toward involved chemistry with the facts and do not prevent the properties of the target compound or the efficacy of particular solvents or reagents. The use of chemistry in a way that maximizes benefits while reducing adverse effects has come to be green chemistry. Main findings: Reduce the use and formation of harmful products or by-products. Presently maximum pollution to the environment is caused by some chemical industries. So, need to design and develop synthetic methods in such a way that the waste products are lowest and have no effect on the environment and their handy disposal. Applications of the work: Green chemistry plays a vital role in pharmaceuticals for developing new drugs which are less toxic, more effective with low side effects. The novelty of the work: The industries performing manufacturing using green synthesis methods to carrying out their productions have positive impacts on environmental sustainability. This review is looking ahead at longer-term challenges and prospects in research, industrial applications, and education.

Facile one-pot green synthesis of tetrahydrobiphenylene-1,3-dicarbonitriles in aqueous media under ultrasound irradiation

2016 ◽  
Vol 42 (12) ◽  
pp. 8097-8108 ◽  
Author(s):  
Nhlanhla Gracious Shabalala ◽  
Suresh Maddila ◽  
Sreekantha B. Jonnalagadda
Keyword(s):  
Green Synthesis ◽  
Aqueous Media ◽  
Ultrasound Irradiation ◽  
One Pot

Facile Synthesis of Quinolines in Water

2020 ◽  
Vol 24 ◽  
Author(s):  
Gongutri Borah ◽  
Preetishmita Borah ◽  
Arnav Bhuyan ◽  
Bimal Krishna Banik
Keyword(s):  
Green Chemistry ◽  
Organic Synthesis ◽  
Heterocyclic Compounds ◽  
Structural Diversity ◽  
Chemical Processes ◽  
New Drugs ◽  
Quinoline Derivatives ◽  
Facile Synthesis ◽  
Environmentally Safe ◽  
Physical And Chemical

: Reactions in water have demonstrated numerous surprising results. The effects of water in these reactions may include significant physical and chemical interactions with the substrates and catalysts through polar effects and hydrogen bonding ability. In some instances, water is also able to interact with the intermediates of reactions and possibly with the transition states of chemical processes. Organic synthesis in water encourages the researchers to follow the principles of green chemistry. Among heterocyclic compounds, quinoline scaffold has become an important motif for the development of new drugs. They are widely found in pharmaceuticals as well as in agrochemical industry. Over the last few decades, numerous reports have been documented to access quinoline derivatives with structural diversity, either by new annulation or by ring functionalization. This review summarizes an overview of the synthesis and functionalisation of quinoline scaffolds in aqueous medium. This method may encourage researchers to adopt green chemistry and to apply these environmentally safe methods in designing important heterocyclic cores.

Lipase-Catalyzed Synthesis of Sucrose Fatty Acid Ester and the Mechanism of Ultrasonic Promoting Esterification Reaction in Non-Aqueous Media

2014 ◽  
Vol 881-883 ◽  
pp. 35-41 ◽  
Author(s):  
Jia Chan Zhang ◽  
Chan Zhang ◽  
Lei Zhao ◽  
Cheng Tao Wang
Keyword(s):  
Fatty Acid ◽  
Ultrasonic Irradiation ◽  
Fatty Acid Ester ◽  
Acid Ester ◽  
Aqueous Media ◽  
Ultrasound Irradiation ◽  
Novozym 435 ◽  
Esterification Reaction ◽  
Irradiation Treatment ◽  
Sucrose Fatty Acid Ester

The preparation of sucrose fatty acid ester (SFAE) by lipase-catalyzing reaction usingCandida antarcticalipase B (CalB) and its immobilized form Novozym 435 was reported in this work. The preparation was characterized in non-aqueous media with and without ultrasound irradiation treatment. A conversion rate of SFAE up to 49.60% was achieved using Novozym 435 under the optimal conditions (45.4°C; mole ratio of methyl oleate to sucrose = 6.0:1; 4.0 mL acetone; 4.0 mg/mL Novozym 435; and 24.6 h of reaction). Under optimal ultrasound conditions (50 kHz, 0.15 W/cm2, 166.55 min), reaction time decreased by 75% approximately, compared with the control without ultrasonic irradiation, but the ultrasound irradiation treatment did not affect the SFAE yield catalyzed by Novozym 435. In the CalB-catalyzed preparation of SFAE under the same optimal reaction conditions, ultrasonic irradiation enhanced the activity of CalB during early time points and inhibited its activity after a long period of treatment. Moreover, CalB was further examined using Far-UV circular dichroism (CD) spectroscopy and scanning electron microscopy (SEM) to study the conformation and micro-morphology of CalB structural variations in various ultrasound irradiation treatments. CD results indicated that α-helical regions were increased and random coil regions remained at a similar level of proportion. SEM images showed small holes appeared on the surface of irradiated CalB. Therefore, we conclude that proper ultrasound irradiation could change the secondary structure and the surface morphology of the CalB in molecular level, and could accelerate the esterification reaction process.

Green Synthesis of Hydantoins and Derivatives

2020 ◽  
Vol 17 (2) ◽  
pp. 176-184
Author(s):  
Lluvia Itzel López-López ◽  
Denisse de Loera ◽  
Ernesto Rivera-Avalos ◽  
Aidé Sáenz-Galindo
Keyword(s):  
Ionic Liquids ◽  
Green Chemistry ◽  
Green Synthesis ◽  
Bioactive Compounds ◽  
Solid Phase ◽  
Ultrasound Irradiation ◽  
Solvent Free ◽  
Pharmacological Properties ◽  
Solvent Free Synthesis

The hydantoin moiety is found in several bioactive compounds with important pharmacological properties such as antimicrobial, antifungal, anti-androgens, anticancer and the historical action anticonvulsant. Because of these reasons, the synthesis of these compounds and their derivatives is important to review considering the philosophy of the green chemistry. In this review, we present the actual importance in the green synthesis of hydantoins and their derivatives using green methods, such as microwave and ultrasound irradiation, ionic liquids, solid-phase and solvent-free synthesis. Finally, several green protocols reported have been discussed.

Metallic Nanoparticle Synthesis by Green Chemistry

2018 ◽  
Vol 11 (6) ◽  
pp. 4287-4294
Author(s):  
Anikate Sood ◽  
Shweta Agarwal
Keyword(s):  
Green Chemistry ◽  
Green Synthesis ◽  
Biomedical Research ◽  
Metallic Nanoparticles ◽  
Nanoparticle Synthesis ◽  
Synthesis Methods ◽  
Metallic Nanoparticle ◽  
Medical Field ◽  
Advantages And Disadvantages ◽  
Gold Silver

Nanotechnology is the most sought field in biomedical research. Metallic nanoparticles have wide applications in the medical field and have gained the attention of various researchers for advanced research for their application in pharmaceutical field. A variety of metallic nanoparticles like gold, silver, platinum, palladium, copper and zinc have been developed so far. There are different methods to synthesize metallic nanoparticles like chemical, physical, and green synthesis methods. Chemical and physical approaches suffer from certain drawbacks whereas green synthesis is emerging as a nontoxic and eco-friendly approach in production of metallic nanoparticles. Green synthesis is further divided into different approaches like synthesis via bacteria, fungi, algae, and plants. These approaches have their own advantages and disadvantages. In this article, we have described various metallic nanoparticles, different modes of green synthesis and brief description about different metabolites present in plant that act as reducing agents in green synthesis of metallic nanoparticles. 

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