ChemInform Abstract: Synthetic Amphiphilic Peptides That Self-Assemble to Membrane-Active Anion Transporters

ChemInform ◽  
2012 ◽  
Vol 43 (30) ◽  
pp. no-no
Author(s):  
George W. Gokel ◽  
Megan M. Daschbach
Keyword(s):  
Amphiphilic Peptides ◽  
Anion Transporters ◽  
Active Anion

Synthetic Amphiphilic Peptides that Self-Assemble to Membrane-Active Anion Transporters

2011 ◽  
pp. 465-519
Author(s):  
George W. Gokel ◽  
Megan M. Daschbach
Keyword(s):  
Amphiphilic Peptides ◽  
Anion Transporters ◽  
Active Anion

scholarly journals Fluorinated synthetic anion carriers: experimental and computational insights into transmembrane chloride transport

2019 ◽  
Vol 10 (7) ◽  
pp. 1976-1985 ◽  
Author(s):  
Michael J. Spooner ◽  
Hongyu Li ◽  
Igor Marques ◽  
Pedro M. R. Costa ◽  
Xin Wu ◽  
...  
Keyword(s):  
Lipid Bilayers ◽  
Cell Membranes ◽  
Chloride Transport ◽  
Anion Transporters ◽  
Highly Active ◽  
Active Anion

A series of fluorinated tripodal tris-thioureas function as highly active anion transporters across lipid bilayers and cell membranes.

scholarly journals 1,8-Diamidocarbazoles: an easily tuneable family of fluorescent anion sensors and transporters

2018 ◽  
Vol 16 (28) ◽  
pp. 5188-5196 ◽  
Author(s):  
Krzysztof M. Bąk ◽  
Krzysztof Chabuda ◽  
Helena Montes ◽  
Roberto Quesada ◽  
Michał J. Chmielewski
Keyword(s):  
Fluorescent Sensors ◽  
Turn On ◽  
Anion Transporters ◽  
Highly Active ◽  
Anion Sensors ◽  
Active Anion

Simple and easy to make diamidocarbazoles have been shown to be highly active anion transporters and sensitive turn-ON fluorescent sensors for H2PO4− and AcO−.

Carbazole-based bis-ureas and thioureas as electroneutral anion transporters

2021 ◽  
pp. 1-7
Author(s):  
Patrick Wang ◽  
Xin Wu ◽  
Philip A. Gale
Keyword(s):  
Anion Transporters

scholarly journals The interaction of calmodulin with amphiphilic peptides.

1985 ◽  
Vol 260 (4) ◽  
pp. 2527-2534 ◽  
Author(s):  
J A Cox ◽  
M Comte ◽  
J E Fitton ◽  
W F DeGrado
Keyword(s):  
Amphiphilic Peptides

scholarly journals Inhibition of jack bean urease by amphiphilic peptides

2021 ◽  
Author(s):  
Zafar Ali Shah ◽  
Sadam Hussain ◽  
Serab Khan ◽  
Nawab Ali ◽  
Samiullah Burki ◽  
...  
Keyword(s):  
Jack Bean Urease ◽  
Jack Bean ◽  
Amphiphilic Peptides

scholarly journals Tenofovir and Severe Symptomatic Hypophosphatemia

2019 ◽  
Vol 7 ◽  
pp. 232470961984879 ◽  
Author(s):  
Asim Kichloo ◽  
Savneek Singh Chugh ◽  
Sanjeev Gupta ◽  
Jay Panday ◽  
Ghazaleh Goldar
Keyword(s):  
Renal Damage ◽  
Organic Anion ◽  
Significant Risk ◽  
Anion Transporters ◽  
Immunodeficiency Virus ◽  
Tubular Lumen ◽  
Associated Proteins ◽  
Proximal Tubular ◽  
Renal Tubular ◽  
Initial Results

Tenofovir is a broadly used drug used for the treatment of human immunodeficiency virus (HIV). Although the initial results of the clinical trials supported the renal safety of Tenofovir, clinical use of it has caused a low, albeit a significant, risk of renal damage either in the form of AKI or CKD. The pathophysiology has been linked to the effect of this medication on the proximal tubular cell. Although the exact mechanism is unknown, studies have suggested that Tenofovir accumulates in proximal tubular cells which are rich in mitochondria. It is both filtered in the glomerulus and actively secreted in the tubules for elimination and is excreted unchanged in the urine. Studies have shown an active transportation of 20-30% of this drug into the renal proximal tubule (PCT) cells via the organic anion transporters in the baso-lateral membrane (primarily hOAT1, and OAT3 to a lesser extent) and ultimate excretion of the drug into the tubular lumen via the transporters in the proximal tubular apical membrane MRP4 and MRP2 (multidrug resistance-associated proteins 2 & 4). Subsequently, the mitochondrial injury caused by Tenofovir can lead to the development of Fanconi’s syndrome which causes renal tubular acidosis, phosphaturia, aminoaciduria, glucosuria with normoglycemia, and tubular proteinuria. Here we present a case where Tenofovir treatment resulted in severe hypophosphatemia requiring hospitalization for parentral phosphate repletion.

Counter-flow suggests transport of dantrolene and 5-OH dantrolene by the organic anion transporters 2 (OAT2) and 3 (OAT3)

2016 ◽  
Vol 468 (11-12) ◽  
pp. 1909-1918 ◽  
Author(s):  
Birgitta C. Burckhardt ◽  
Maja Henjakovic ◽  
Yohannes Hagos ◽  
Gerhard Burckhardt
Keyword(s):  
Organic Anion ◽  
Organic Anion Transporters ◽  
Counter Flow ◽  
Anion Transporters

Integrated Approach of In Vivo and In Vitro Evaluation of the Involvement of Hepatic Uptake Organic Anion Transporters in the Drug Disposition in Rats Using Rifampicin as an Inhibitor

2013 ◽  
Vol 41 (7) ◽  
pp. 1442-1449 ◽  
Author(s):  
Tomoki Imaoka ◽  
Tsuyoshi Mikkaichi ◽  
Koji Abe ◽  
Masakazu Hirouchi ◽  
Noriko Okudaira ◽  
...  
Keyword(s):  
Drug Disposition ◽  
Organic Anion ◽  
Integrated Approach ◽  
Hepatic Uptake ◽  
Organic Anion Transporters ◽  
In Vitro Evaluation ◽  
Anion Transporters
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