Background:
A convenient and efficient methodology for the synthesis of quinazolin-
4(3H)-ones from simple and readily available 2-amino benzamides and aromatic aldehydes in ethanol
using Magnesium perchlorate are being reported in the present study. Good to excellent isolated yields
(68-95%) of the corresponding 2-substituted quinazolinones were obtained under mild reaction conditions
with excellent functional group tolerance. The affordability of the catalyst, the wide availability
of the starting materials, transition metal free synthesis and the simplicity of the procedure renders the
present methodology useful in organic synthesis.
Objective:
A maneuver methodology developed for the synthesis of quinazolin-4(3H)-ones via using
Magnesium perchlorate from 2-amino benzamides and aromatic aldehydes in ethanol.
Methods:
10% mol anhydrous Magnesium perchlorate in presence of ethanol give to simply rapid
formation of Quinazolin-4(3H)-ones from 1 mole of 2-amino benzamides and 1 mole of aromatic aldehydes.
Results:
Screening results of Anti-leishmanial showed that out of the synthesized series of 12 compounds,
compounds 3c, 3d, 3g, 3h and 3i showed significant antileishmanial activities (L. donavani)
with IC50 values 8.39, 9.37, 9.43, 7.1 and 8.7 μM.
Conclusion:
In summary, we have developed convenient synthesis of quinazolin-4(3H)-one, from
simple and easily available precursor employing anhydrous Mg(ClO4)2 under green conditions.