ChemInform Abstract: Amarusine A, a New Dioxaspiro[4.4]nonane Derivative with a Butyrolactone Ring from Pleioblastus amarus.

ChemInform ◽  
2014 ◽  
Vol 46 (3) ◽  
pp. no-no
Author(s):  
Jia Sun ◽  
Peicheng Zhang ◽  
Qi Wei ◽  
Hang Xun ◽  
Feng Tang ◽  
...  
Keyword(s):  
Heterocycles ◽  
2002 ◽  
Vol 58 (1) ◽  
pp. 57 ◽  
Author(s):  
Kin-ichi Tadano ◽  
Shin-ya Aoki ◽  
Takahiro Ohi ◽  
Kazuya Shimizu ◽  
Ryota Shiraki ◽  
...  

2014 ◽  
Vol 24 (3) ◽  
pp. 152-153 ◽  
Author(s):  
Polina N. Veremeeva ◽  
Irina V. Grishina ◽  
Vera L. Lapteva ◽  
Alexander A. Yaroslavov ◽  
Andrey V. Sybachin ◽  
...  

ChemInform ◽  
2010 ◽  
Vol 24 (16) ◽  
pp. no-no
Author(s):  
V. SIEMUND ◽  
H. IRNGARTINGER ◽  
C. SIGWART ◽  
B. KISSLER ◽  
R. GLEITER
Keyword(s):  

2020 ◽  
Vol 66 (3) ◽  
pp. 257-264
Author(s):  
G.E. Brkich ◽  
N.V. Pyatigorskaya ◽  
V.V. Beregovykh ◽  
O.A. Zyryanov ◽  
N.B. Demina ◽  
...  

Physicochemical properties of the original pharmaceutical substance TST-9 based on the 3,7-diazabicyclo[3.3.1]nonane derivative with the chemical name IUPAC 6-[4methoxy-3-(1H-pyrazol-1-ylmethyl) benzyl]-1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.1]tetradecane-4,8,12-trion, were studied. TST-9 is used as an active substance for the development of the composition and technology for the preparation of an innovative oral drug. The pharmaceutical substance TST-9 is an amorphous white powder, odorless, soluble in chloroform, acetonitrile, methylene chloride, acetone, dimethyl sulfoxide, dimethylformamide and alcohol, sparingly soluble in diethyl ether, dioxane and is very slightly soluble in water, hexane, and heptane. The melting point ranged from 94°C to 96°C without visible decomposition of the substance. The microbiological purity corresponds to category 2.2. Residual organic solvents in the form of chloroform did not exceed 0.006%. The amount of impurities was not more than 0.15%. The loss in mass upon drying was not more than 0.5%. The “identity” was confirmed using nuclear magnetic resonance spectroscopy and HPLC with UV detection. The data obtained in the study will contribute to the further development of the dosage form, the choice of the route of administration and the dosage regimen, as well as the selection of analytical methods for analyzing the quality of the finished dosage form and the effective, high-precision determination of the content of the active substance and its likely decay products.


2013 ◽  
Vol 8 (7) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Masahiro Uwamori ◽  
Masahisa Nakada

The total synthesis of clusianone was accomplished through the stereoselective construction of a bicyclo[3.3.1]nonane derivative via a three-step sequence which has been utilized for the total syntheses of nemorosone garsubellin A and hyperforin: intramolecular cyclopropanation formation of a geminal dimethyl group and regioselective ring opening of cyclopropane. Further elaboration including chemo- and stereoselective hydrogenation to generate the C7 stereogenic center and cross-metathesis to construct prenyl groups in the side-chains was employed to complete the total synthesis of clusianone.


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