ChemInform Abstract: Design and Synthesis of Optically Pure 3-Aryl-6-methyl-2-thioxotetrahydropyrimidin-4(1H)-ones as anti-Prostate Cancer Agents.

ChemInform ◽  
2015 ◽  
Vol 46 (11) ◽  
pp. no-no
Author(s):  
Varun Kumar ◽  
Mahesh Rachamalla ◽  
Prajwal Nandekar ◽  
Gopal L. Khatik ◽  
Abhay T. Sangamwar ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Design And Synthesis ◽  
Optically Pure

Design and synthesis of optically pure 3-aryl-6-methyl-2-thioxotetrahydropyrimidin-4(1H)-ones as anti-prostate cancer agents

RSC Advances ◽  
2014 ◽  
Vol 4 (71) ◽  
pp. 37868-37877 ◽  
Author(s):  
Varun Kumar ◽  
Mahesh Rachamalla ◽  
Prajwal Nandekar ◽  
Gopal L. Khatik ◽  
Abhay T. Sangamwar ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Design And Synthesis ◽  
New Class ◽  
Optically Pure

3-Aryl-6-methyl-2-thioxotetrahydropyrimidin-4(1H)-ones were designed and synthesized as a new class of anti-prostate cancer agents.

Design and synthesis of a phenyl C-glycoside derivative of Spliceostatin A and its biological evaluation toward prostate cancer treatment

2019 ◽  
Vol 60 (51) ◽  
pp. 151313 ◽  
Author(s):  
Yusuke Yoshikawa ◽  
Airi Ishibashi ◽  
Kenichi Murai ◽  
Yasufumi Kaneda ◽  
Keisuke Nimura ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Treatment ◽  
Biological Evaluation ◽  
Prostate Cancer Treatment ◽  
Design And Synthesis ◽  
Spliceostatin A

scholarly journals Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer

2016 ◽  
Vol 118 ◽  
pp. 230-243 ◽  
Author(s):  
Marcella Bassetto ◽  
Salvatore Ferla ◽  
Fabrizio Pertusati ◽  
Sahar Kandil ◽  
Andrew D. Westwell ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Antiproliferative Agents ◽  
Design And Synthesis

Design and synthesis of an androgen receptor pure antagonist (CH5137291) for the treatment of castration-resistant prostate cancer

2010 ◽  
Vol 18 (23) ◽  
pp. 8150-8157 ◽  
Author(s):  
Hitoshi Yoshino ◽  
Haruhiko Sato ◽  
Takuya Shiraishi ◽  
Kazutaka Tachibana ◽  
Takashi Emura ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Castration Resistant Prostate Cancer ◽  
Design And Synthesis ◽  
Castration Resistant

Design and Synthesis of a PSMA Inhibitor–Doxorubicin Conjugate for Targeted Prostate Cancer Therapy

ChemMedChem ◽  
2006 ◽  
Vol 1 (3) ◽  
pp. 299-302 ◽  
Author(s):  
Sarva Jayaprakash ◽  
Xinning Wang ◽  
Warren D. Heston ◽  
Alan P. Kozikowski
Keyword(s):  
Prostate Cancer ◽  
Cancer Therapy ◽  
Design And Synthesis ◽  
Prostate Cancer Therapy ◽  
Psma Inhibitor

Design and Synthesis of Sulfonamide-1,2,3-Triazole Derivatives Bearing a Dithiocarbamate Moiety as Antiproliferative Agents

2017 ◽  
Vol 41 (9) ◽  
pp. 523-525 ◽  
Author(s):  
Dong-Jun Fu ◽  
Ying-Chao Liu ◽  
Jia-Jia Yang ◽  
Ji Zhang ◽  
Chao-Dong Xiong ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Line ◽  
Prostate Cancer Cell Line ◽  
Triazole Derivatives ◽  
Antitumour Agents ◽  
Design And Synthesis ◽  
Lead Compounds ◽  
Substituted Piperazine

A series of nine novel 1-(4′-sulfamoylphenyl)-1,2,3-triazole derivatives bearing a 4-dithiocarbamylmethyl moiety were designed using the molecular hybridisation approach and synthesised by alkyne/azide click chemistry. Most of the synthesised compounds exhibited moderate to good antiproliferative activity against oesophagus, gastric and prostate cancer cell lines, but a compound containing a 4-( t-butoxycarbonyl)piperazinylthiocarbonyl moiety showed the highest activity. Against a prostate cancer cell line, it had an IC50 value of 2.4 μM, about 10-fold more active than 5-flurouracil. This work shows that novel sulfonamide-1,2,3-triazole derivatives bearing a dithiocarbamate moiety linked to a 4-substituted piperazine are promising lead compounds for the development of antitumour agents.

scholarly journals Rational design and synthesis of novel phenylsulfonyl-benzamides as anti-prostate cancer agents

MedChemComm ◽  
2017 ◽  
Vol 8 (7) ◽  
pp. 1414-1420 ◽  
Author(s):  
Marcella Bassetto ◽  
Salvatore Ferla ◽  
Gilda Giancotti ◽  
Fabrizio Pertusati ◽  
Andrew D. Westwell ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Rational Design ◽  
Molecular Scaffold ◽  
Design And Synthesis ◽  
Anti Cancer ◽  
Cancer Activity

A novel antiproliferative molecular scaffold was designed by rational modification of known antiandrogens, achieving a significant improvement in anti-cancer activity.

scholarly journals Rational design and synthesis of novel anti-prostate cancer agents bearing a 3,5-bis-trifluoromethylphenyl moiety

2016 ◽  
Vol 26 (15) ◽  
pp. 3636-3640 ◽  
Author(s):  
Salvatore Ferla ◽  
Marcella Bassetto ◽  
Fabrizio Pertusati ◽  
Sahar Kandil ◽  
Andrew D. Westwell ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Rational Design ◽  
Design And Synthesis
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